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TUBG1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247708

MBS247708 is an antibody targeting TUBG1. Also known as Rabbit Polyclonal (IgG) to Human TUBG1 / Tubulin Gamma 1. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TUBG1 / Tubulin Gamma 1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human TUBG1 / Tubulin Gamma 1
Product Gene Name
anti-TUBG1 antibody
Product Synonym Names
Anti-TUBG1 / Tubulin Gamma 1 Antibody (aa386-435) IHC-plus; TUBG1; Gamma-1-tubulin; GCP-1; Gamma Tubulin; TUBGCP1; Tubulin gamma chain; TUBG; Tubulin; gamma polypeptide; Tubulin gamma-1 chain; Tubulin; gamma 1; Tubulin Gamma 1; Human TUBG1; Tubulin Gamma 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Tubulin gamma Antibody detects endogenous levels of total Tubulin gamma protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
51,170 Da
OMIM
gene 615412
3D Structure
ModBase 3D Structure for P23258
Target Species
Human
Immunogen Description
Synthetic peptide from human Tubulin gamma (aa386-435).
Immunogen
TUBG1 / Tubulin Gamma 1 antibody was raised against synthetic peptide from human Tubulin gamma (aa386-435).
Antigen Modification
aa386-435
Applications Tested/Suitable for anti-TUBG1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-TUBG1 antibody
ELISA (1:5000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-TUBG1 antibody

Anti-TUBG1 / Gamma Tubulin antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-TUBG1 Polyclonal Antibody – Cat# MBS247708

Western Blot (WB) of anti-TUBG1 antibody

Western blot of extracts from mouse brain cells, using Tubulin gamma Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-TUBG1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS247708

Other Notes

Small volumes of anti-TUBG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TUBG1. It may not necessarily be applicable to this product.

NCBI GI #
31543831
NCBI GeneID
7283
NCBI Accession #
NP_001061.2
UniProt Primary Accession #
P23258
UniProt Secondary Accession #
Q53X79; Q9BW59
UniProt Related Accession #
P23258
GenBank Nucleotide #
NM_001070.4
NCBI Official Full Name
tubulin gamma-1 chain
NCBI Official Synonym Full Names
tubulin, gamma 1
NCBI Official Symbol
TUBG1
NCBI Official Synonym Symbols
TUBG; GCP-1; CDCBM4; TUBGCP1
UniProt Protein Name
Tubulin gamma-1 chain
UniProt Synonym Protein Names
Gamma-1-tubulin; Gamma-tubulin complex component 1; GCP-1
UniProt Gene Name
TUBG1
UniProt Synonym Gene Names
TUBG; GCP-1
UniProt Entry Name
TBG1_HUMAN
NCBI Protein Information
tubulin gamma-1 chain; tubulin, gamma polypeptide; gamma-tubulin complex component 1

NCBI Summary for TUBG1

This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]
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UniProt Comments for TUBG1

TUBG1: Tubulin is the major constituent of microtubules. Gamma tubulin is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta tubulin minus-end nucleation, centrosome duplication and spindle formation. Interacts with GCP2 and GCP3. Interacts with B9D2. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO/C1orf88. Belongs to the tubulin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: centriole; centrosome; recycling endosome; pericentriolar material; condensed nuclear chromosome; apical part of cell; cytoplasmic microtubule; nonmotile primary cilium; cytoplasm; leading edge; polar microtubule; cytosol; gamma-tubulin complex

Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton

Biological Process: metabolic process; organelle organization and biogenesis; mitotic cell cycle; microtubule cytoskeleton organization and biogenesis; G2/M transition of mitotic cell cycle; microtubule nucleation; meiotic spindle organization and biogenesis; cytoplasmic microtubule organization and biogenesis

Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 4
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Research Articles on TUBG1

1. Recombinant gamma-tubulin can be phosphorylated by Cdk1-cyclin B or Brsk1 and dephosphorylated by Ppp4c-R2-R3A in vitro.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TUBG1 antibody

 Products by Pathway  Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organizationfrom The Centrosome Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram

Diseases associated with anti-TUBG1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with TUBG1 and Nervous System Diseases
 Malformations of Cortical Development Antibodies  >4 publications with TUBG1 and Malformations of Cortical Development
 Microcephaly Antibodies  >2 publications with TUBG1 and Microcephaly
 Multiple Myeloma Antibodies  >1 publications with TUBG1 and Multiple Myeloma
 Carcinoma Antibodies  >1 publications with TUBG1 and Carcinoma
 Breast Neoplasms Antibodies  >1 publications with TUBG1 and Breast Neoplasms

Organs/Tissues associated with anti-TUBG1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with TUBG1 and Brain
 Embryonic Tissue Antibodies  >4 publications with TUBG1 and Embryonic Tissue
 Muscle Antibodies  >1 publications with TUBG1 and Muscle
 Lung Antibodies  >1 publications with TUBG1 and Lung
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