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KRT10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247716

This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with… More details

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Product Overview

Product Name
KRT10 / CK10 / Cytokeratin 10, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human KRT10 / CK10 / Cytokeratin 10
Product Gene Name
anti-KRT10 antibody
Product Synonym Names
Anti-KRT10 / CK10 / Cytokeratin 10 Antibody (aa136-185) IHC-plus; KRT10; BIE; BCIE; CK10; Cytokeratin 10; Cytokeratin-10; EHK; Keratin-10; KPP; Keratin 10; CK-10; K10; Human KRT10; CK10; Cytokeratin 10
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Keratin 10 Antibody detects endogenous levels of total Keratin 10 protein.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
58,827 Da
OMIM
phenotype 609165
3D Structure
ModBase 3D Structure for P13645
Target Species
Human
Immunogen Description
Synthetic peptide from human Keratin 10 (aa136-185).
Immunogen
KRT10 / CK10 / Cytokeratin 10 antibody was raised against synthetic peptide from human Keratin 10 (aa136-185).
Antigen Modification
aa136-185
Applications Tested/Suitable for anti-KRT10 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-KRT10 antibody
ELISA (1:5000), IF (1:100 - 1:500), IHC-P (5 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-KRT10 antibody

Anti-KRT10 / Cytokeratin 10 antibody IHC of human skin, epidermis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-KRT10 Polyclonal Antibody – Cat# MBS247716

Immunofluorescence (IF) of anti-KRT10 antibody

Immunofluorescence of A549 cells, using Keratin 10 Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-KRT10 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS247716

Western Blot (WB) of anti-KRT10 antibody

Western blot of extracts from HeLa cells, using Keratin 10 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-KRT10 Polyclonal Antibody, Western Blot (WB) – Cat# MBS247716

Other Notes

Small volumes of anti-KRT10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KRT10 purchase

MBS247716 is an antibody targeting KRT10. Also known as Rabbit Polyclonal (IgG) to Human KRT10 / CK10 / Cytokeratin 10. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KRT10. It may not necessarily be applicable to this product.

NCBI GI #
195972866
NCBI GeneID
3858
NCBI Accession #
NP_000412.3
UniProt Primary Accession #
P13645
UniProt Secondary Accession #
Q14664; Q8N175
UniProt Related Accession #
P13645
GenBank Nucleotide #
NM_000421.3
NCBI Official Full Name
keratin, type I cytoskeletal 10
NCBI Official Synonym Full Names
keratin 10
NCBI Official Symbol
KRT10
NCBI Official Synonym Symbols
BIE; EHK; K10; KPP; BCIE; CK10
UniProt Protein Name
Keratin, type I cytoskeletal 10
UniProt Synonym Protein Names
Cytokeratin-10; CK-10; Keratin-10; K10
Protein Family
Keratin
UniProt Gene Name
KRT10
UniProt Synonym Gene Names
KPP; CK-10; K10
UniProt Entry Name
K1C10_HUMAN
NCBI Protein Information
keratin, type I cytoskeletal 10; CK-10; keratin-10; cytokeratin 10

NCBI Summary for KRT10

This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. [provided by RefSeq, Jul 2008]
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UniProt Comments for KRT10

K10: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K1.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: extracellular space; membrane; keratin filament; cytoplasm; intermediate filament; nucleus

Molecular Function: structural constituent of epidermis

Biological Process: keratinocyte differentiation

Disease: Erythroderma, Ichthyosiform, Congenital Reticular; Epidermolytic Hyperkeratosis; Ichthyosis, Cyclic, With Epidermolytic Hyperkeratosis
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Research Articles on KRT10

1. Case Report: extensive postzygotic mosaicism for a novel keratin 10 mutation in epidermolytic ichthyosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KRT10 antibody

 Reference Product  PubMed Publications
 GLE1 antibody  >1 publications with KRT10 and GLE1
 SRC antibody  >1 publications with KRT10 and SRC
 AKT1 antibody  >1 publications with KRT10 and AKT1
 IVL antibody  >1 publications with KRT10 and IVL

Pathways associated with anti-KRT10 antibody

 Products by Pathway  Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram
 Staphylococcus Aureus Infection Pathway antibodies  Staphylococcus Aureus Infection Pathway Diagram

Diseases associated with anti-KRT10 antibody

 Disease Name  Pubmed Publications
 Hyperkeratosis, Epidermolytic Antibodies  >42 publications with KRT10 and Hyperkeratosis, Epidermolytic
 Carcinoma, Squamous Cell Antibodies  >18 publications with KRT10 and Carcinoma, Squamous Cell
 Skin Neoplasms Antibodies  >10 publications with KRT10 and Skin Neoplasms
 Inflammation Antibodies  >9 publications with KRT10 and Inflammation
 Necrosis Antibodies  >6 publications with KRT10 and Necrosis
 Breast Neoplasms Antibodies  >5 publications with KRT10 and Breast Neoplasms
 Lung Neoplasms Antibodies  >4 publications with KRT10 and Lung Neoplasms
 Disease Models, Animal Antibodies  >4 publications with KRT10 and Disease Models, Animal
 Ovarian Neoplasms Antibodies  >4 publications with KRT10 and Ovarian Neoplasms
 Ovarian Diseases Antibodies  >4 publications with KRT10 and Ovarian Diseases

Organs/Tissues associated with anti-KRT10 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >104 publications with KRT10 and Skin
 Mouth Antibodies  >11 publications with KRT10 and Mouth
 Lung Antibodies  >6 publications with KRT10 and Lung
 Esophagus Antibodies  >2 publications with KRT10 and Esophagus
 Embryonic Tissue Antibodies  >2 publications with KRT10 and Embryonic Tissue
 Ovary Antibodies  >2 publications with KRT10 and Ovary
 Vascular Antibodies  >2 publications with KRT10 and Vascular
 Cervix Antibodies  >1 publications with KRT10 and Cervix
 Eye Antibodies  >1 publications with KRT10 and Eye
 Brain Antibodies  >1 publications with KRT10 and Brain
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