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DCYTB Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247719

MBS247719 is an antibody targeting DCYTB. Also known as Goat Polyclonal to Human DCYTB / CYBRD1. Reactive in Gibbon, Gorilla, Human, OrangutanPredicted Reactivity: Monkey, Pig, Rabbit (at least 90% immunogen sequence identity). Host: Goat. More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Product Overview

Product Name
DCYTB / CYBRD1, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human DCYTB / CYBRD1
Product Gene Name
anti-DCYTB antibody
Product Synonym Gene Name
CYBRD1
Product Synonym Names
Anti-DCYTB / CYBRD1 Antibody (C-Terminus) IHC-plus; CYBRD1; DCYTB; Duodenal cytochrome b; Ferric-chelate reductase 3; Cytochrome b reductase 1; FRRS3; Human DCYTB; CYBRD1
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Gorilla, Human, Orangutan
Predicted Reactivity: Monkey, Pig, Rabbit (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human CYBRD1 / DCYTB. This antibody is expected to recognise isoform 1 (NP_079119.3) only.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
25,087 Da
OMIM
605745
3D Structure
ModBase 3D Structure for Q53TN4
Target Species
Human
Immunogen Description
Synthetic peptide C-RNLALDEAGQRSTM from the C-terminus of human CYBRD1 / DCYTB (NP_079119.3). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey (100%); Marmoset, Rabbit, Pig, Platypus (93%).
Immunogen Type
Synthetic peptide
Immunogen
DCYTB / CYBRD1 antibody was raised against synthetic peptide C-RNLALDEAGQRSTM from the C-terminus of human CYBRD1 / DCYTB (NP_079119.3). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey (100%); Marmoset, Rabbit, Pig, Platypus (93%); Goat, Bovine, Horse, Opossum, Turkey, Chicken, Xenopus (86%).
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-DCYTB antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-DCYTB antibody
ELISA (1:16000), IHC-P (2.5 ug/ml)

Immunohistochemistry (IHC) of anti-DCYTB antibody

Anti-CYBRD1 / DCYTB antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Goat Anti-DCYTB Polyclonal Antibody – Cat# MBS247719

Immunohistochemistry (IHC) of anti-DCYTB antibody

Anti-CYBRD1 / DCYTB antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Goat Anti-DCYTB Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247719

Other Notes

Small volumes of anti-DCYTB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DCYTB. It may not necessarily be applicable to this product.

NCBI GI #
188536036
NCBI GeneID
79901
NCBI Accession #
NP_079119.3
UniProt Primary Accession #
Q53TN4
UniProt Secondary Accession #
Q6KC16; Q6KC17; Q6P147; Q6ZR51; Q9H0Q8; Q9H5G5; B2RE79; B4DWD7
UniProt Related Accession #
Q53TN4
GenBank Nucleotide #
NM_024843.3
NCBI Official Full Name
cytochrome b reductase 1 isoform 1
NCBI Official Synonym Full Names
cytochrome b reductase 1
NCBI Official Symbol
CYBRD1
NCBI Official Synonym Symbols
DCYTB; FRRS3; CYB561A2
UniProt Protein Name
Cytochrome b reductase 1
UniProt Synonym Protein Names
Duodenal cytochrome b; Ferric-chelate reductase 3
UniProt Gene Name
CYBRD1
UniProt Synonym Gene Names
DCYTB; FRRS3
UniProt Entry Name
CYBR1_HUMAN
NCBI Protein Information
cytochrome b reductase 1; duodenal cytochrome b; ferric-chelate reductase 3; cytochrome b561 family, member A2

NCBI Summary for DCYTB

This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008]

UniProt Comments for DCYTB

CYBRD1: Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.-.-.-; Transporter; Transporter, ion channel; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Transporter, iron; Oxidoreductase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: brush border membrane; integral to membrane; plasma membrane

Molecular Function: oxidoreductase activity, oxidizing metal ions; metal ion binding; ferric-chelate reductase activity

Biological Process: cellular iron ion homeostasis; response to iron ion; transmembrane transport
Show more

Research Articles on DCYTB

1. Polymorphisms in CYBRD1 modulates iron phenotype in HFE p.C282Y homozygous hemochromatosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DCYTB antibody

 Reference Product  PubMed Publications
 HAMP antibody  >12 publications with DCYTB and HAMP
 HFE antibody  >8 publications with DCYTB and HFE
 HEPH antibody  >6 publications with DCYTB and HEPH
 SLC40A1 antibody  >4 publications with DCYTB and SLC40A1
 SLC11A2 antibody  >4 publications with DCYTB and SLC11A2
 TFR2 antibody  >2 publications with DCYTB and TFR2
 HFE2 antibody  >1 publications with DCYTB and HFE2
 SLC39A1 antibody  >1 publications with DCYTB and SLC39A1

Pathways associated with anti-DCYTB antibody

 Products by Pathway  Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-DCYTB antibody

 Disease Name  Pubmed Publications
 Anemia Antibodies  >6 publications with DCYTB and Anemia
 Porphyrias, Hepatic Antibodies  >1 publications with DCYTB and Porphyrias, Hepatic
 Kidney Diseases Antibodies  >1 publications with DCYTB and Kidney Diseases

Organs/Tissues associated with anti-DCYTB antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >20 publications with DCYTB and Intestine
 Liver Antibodies  >15 publications with DCYTB and Liver
 Blood Antibodies  >13 publications with DCYTB and Blood
 Kidney Antibodies  >4 publications with DCYTB and Kidney
 Brain Antibodies  >3 publications with DCYTB and Brain
 Spleen Antibodies  >2 publications with DCYTB and Spleen
 Esophagus Antibodies  >1 publications with DCYTB and Esophagus
 Bone Antibodies  >1 publications with DCYTB and Bone
 Pancreas Antibodies  >1 publications with DCYTB and Pancreas
 Heart Antibodies  >1 publications with DCYTB and Heart
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