Rabbit Anti-SLC5A2 Polyclonal Antibody – Cat# MBS247749

Anti-SLC5A2 antibody IHC of human kidney, collecting duct. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

SLC5A2 Antibody – Rabbit Polyclonal

Name: SLC5A2 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS247749
Price: 630 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247749

MBS247749 is an antibody targeting SLC5A2. Also known as Rabbit Polyclonal to Human SLC5A2 / SGLT2. Reactive in Gibbon, Gorilla, Horse, Human, RatPredicted Reactivity: Monkey, Mouse, Bat, Bovine, Hamster (at least 90% immunogen sequence identity). Host:… More details

$630 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SLC5A2 / SGLT2, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human SLC5A2 / SGLT2

Product Gene Name

anti-SLC5A2 antibody

Product Synonym Gene Name

SGLT2

Product Synonym Names

Anti-SLC5A2 / SGLT2 Antibody (C-Terminus) IHC-plus; SLC5A2; Na(+)/glucose cotransporter 2; SGLT2; Sodium-glucose transporter 2; Sodium/glucose cotransporter 2; Human SLC5A2; SGLT2

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Gibbon, Gorilla, Horse, Human, Rat
Predicted Reactivity: Monkey, Mouse, Bat, Bovine, Hamster (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human SLC5A2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

49,357 Da

OMIM

gene 233100

3D Structure

ModBase 3D Structure for P31639

Target Species

Human

Immunogen Description

Synthetic 17 amino acid peptide from C-terminus of human SLC5A2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Rat, Elephant, Horse (100%); Marmoset, Mouse, Hamster, Bat, Bovine (94%); Dog (88%).

Immunogen Type

Synthetic peptide

Immunogen

SLC5A2 / SGLT2 antibody was raised against synthetic 17 amino acid peptide from C-terminus of human SLC5A2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Rat, Elephant, Horse (100%); Marmoset, Mouse, Hamster, Bat, Bovine (94%); Dog (88%); Panda, Rabbit (82%).

Antigen Modification

C-Terminus

Product Categories/Family for anti-SLC5A2 antibody

Family: Transporter; Subfamily: Solute:sodium symporter

Applications Tested/Suitable for anti-SLC5A2 antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-SLC5A2 antibody

IHC-P (20 ug/ml)

Other Notes

Small volumes of anti-SLC5A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC5A2. It may not necessarily be applicable to this product.

NCBI GI #

4507033

NCBI GeneID

6524

NCBI Accession #

NP_003032.1

UniProt Primary Accession #

P31639

UniProt Secondary Accession #

A2RRD2

UniProt Related Accession #

P31639

GenBank Nucleotide #

NM_003041.3

NCBI Official Full Name

sodium/glucose cotransporter 2

NCBI Official Synonym Full Names

solute carrier family 5 (sodium/glucose cotransporter), member 2

NCBI Official Symbol

SLC5A2

NCBI Official Synonym Symbols

SGLT2

UniProt Protein Name

Sodium/glucose cotransporter 2

UniProt Synonym Protein Names

Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2

Protein Family

Sodium/glucose cotransporter

UniProt Gene Name

SLC5A2

UniProt Synonym Gene Names

SGLT2; Na(+)/glucose cotransporter 2

UniProt Entry Name

SC5A2_HUMAN

NCBI Protein Information

sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; solute carrier family 5 member 2; low affinity sodium-glucose cotransporter; solute carrier family 5 (sodium/glucose transporter), member 2

NCBI Summary for SLC5A2

This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. [provided by RefSeq, Sep 2009]

UniProt Comments for SLC5A2

SLC5A2: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1. Defects in SLC5A2 are the cause of renal glucosuria (GLYS1). GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test. Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: integral to membrane; plasma membrane

Molecular Function: low-affinity glucose:sodium symporter activity

Biological Process: transport; carbohydrate metabolic process; sodium ion transport; glucose transport; transmembrane transport

Disease: Renal Glucosuria

Research Articles on SLC5A2

1. A single dose of canagliflozin, a sodium glucose co-transporter 2 inhibitor, 300 mg reduced both fasting and postprandial PG.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC5A2 antibody

Reference Product	PubMed Publications
SLC2A2 antibody	>2 publications with SLC5A2 and SLC2A2

Pathways associated with anti-SLC5A2 antibody

Products by Pathway	Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Glycogen Storage Diseases Pathway antibodies	Glycogen Storage Diseases Pathway Diagram
Hexose Transport Pathway antibodies	Hexose Transport Pathway Diagram
Inositol Transporters Pathway antibodies	Inositol Transporters Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Carbohydrates Pathway antibodies	Metabolism Of Carbohydrates Pathway Diagram
Myoclonic Epilepsy Of Lafora Pathway antibodies	Myoclonic Epilepsy Of Lafora Pathway Diagram
Na+-dependent Glucose Transporters Pathway antibodies	Na+-dependent Glucose Transporters Pathway Diagram
Orphan Transporters Pathway antibodies	Orphan Transporters Pathway Diagram
SLC-mediated Transmembrane Transport Pathway antibodies	SLC-mediated Transmembrane Transport Pathway Diagram

Diseases associated with anti-SLC5A2 antibody

Disease Name	Pubmed Publications
Glycosuria Antibodies	>50 publications with SLC5A2 and Glycosuria
Glycosuria, Renal Antibodies	>41 publications with SLC5A2 and Glycosuria, Renal
Kidney Diseases Antibodies	>37 publications with SLC5A2 and Kidney Diseases
Weight Loss Antibodies	>17 publications with SLC5A2 and Weight Loss
Cardiovascular Diseases Antibodies	>8 publications with SLC5A2 and Cardiovascular Diseases
Inflammation Antibodies	>7 publications with SLC5A2 and Inflammation
Hypertension Antibodies	>6 publications with SLC5A2 and Hypertension
Death Antibodies	>5 publications with SLC5A2 and Death
Polyuria Antibodies	>3 publications with SLC5A2 and Polyuria
Hypertrophy Antibodies	>3 publications with SLC5A2 and Hypertrophy

Organs/Tissues associated with anti-SLC5A2 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>94 publications with SLC5A2 and Kidney
Pancreas Antibodies	>8 publications with SLC5A2 and Pancreas
Intestine Antibodies	>5 publications with SLC5A2 and Intestine