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NLRP8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247766

MBS247766 is an antibody targeting NLRP8. Also known as Rabbit Polyclonal to Human NLRP8. Reactive in Human. Host: Rabbit. More details

$650 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NLRP8, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human NLRP8
Product Gene Name
Product Synonym Names
Anti-NLRP8 Antibody (N-Terminus) IHC-plus; NLRP8; CLR19.2; NALP8; NOD16; PAN4; Human NLRP8
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human NLRP8
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
117,336 Da
OMIM
609659
3D Structure
ModBase 3D Structure for Q86W28
Target Species
Human
Immunogen Description
A 16 amino acid peptide near the amino terminus of human NALP8.
Immunogen Type
Synthetic peptide
Immunogen
NLRP8 antibody was raised against a 16 amino acid peptide near the amino terminus of human NALP8.
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-NLRP8 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-NLRP8 antibody
ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
Usage: NALP8 antibody can be used for detection of NALP8 by Western blot at 1-2 ug/ml.

Immunohistochemistry (IHC) of anti-NLRP8 antibody

Anti-NLRP8 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-NLRP8 Polyclonal Antibody – Cat# MBS247766

Western Blot (WB) of anti-NLRP8 antibody

Western blot analysis of NALP8 in human colon tissue lysate with NALP8 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-NLRP8 Polyclonal Antibody, Western Blot (WB) – Cat# MBS247766

Other Notes

Small volumes of anti-NLRP8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NLRP8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 8
NCBI Official Synonym Full Names
NLR family, pyrin domain containing 8
NCBI Official Symbol
NLRP8
NCBI Official Synonym Symbols
PAN4; NALP8; NOD16; CLR19.2
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 8
UniProt Synonym Protein Names
Nucleotide-binding oligomerization domain protein 16; PYRIN and NACHT-containing protein 4
UniProt Gene Name
NLRP8
UniProt Synonym Gene Names
NALP8; NOD16; PAN4
UniProt Entry Name
NALP8_HUMAN
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 8; PYRIN and NACHT-containing protein 4; NACHT, LRR and PYD containing protein 8; NACHT, leucine rich repeat and PYD containing 8; nucleotide-binding oligomerization domain protein 16; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 8

NCBI Summary for NLRP8

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP8, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]
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UniProt Comments for NLRP8

NLRP8: Involved in inflammation (Potential). Belongs to the NLRP family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.43

Cellular Component: cytoplasm

Molecular Function: ATP binding

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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