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HELO1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247862

MBS247862 is an antibody targeting HELO1. Also known as Rabbit Polyclonal to Human HELO1 / ELOVL5. Reactive in Gibbon, Gorilla, Human, Orangutan, RabbitPredicted Reactivity: Monkey, Mouse, Dog (at least 90% immunogen sequence identity). Host: Rabbit. More details

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Product Overview

Online Datasheet in PDF
Product Name
HELO1 / ELOVL5, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human HELO1 / ELOVL5
Product Gene Name
anti-HELO1 antibody
Product Synonym Gene Name
ELOVL5
Product Synonym Names
Anti-HELO1 / ELOVL5 Antibody (Internal) IHC-plus; ELOVL5; ELOVL FA elongase 5; ELOVL fatty acid elongase 5; Fatty acid elongase 1; RP3-483K16.1; DJ483K16.1; HELO1; Human HELO1; ELOVL5
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human, Orangutan, Rabbit
Predicted Reactivity: Monkey, Mouse, Dog (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human ELOVL5. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PLAGL1 (39%), PLAG1 (39%).
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
9,580 Da
OMIM
611805
3D Structure
ModBase 3D Structure for Q9NYP7
Target Species
Human
Immunogen Description
Synthetic 18 amino acid peptide from internal region of human ELOVL5. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Elephant, Rabbit (100%); Marmoset, Mouse, Dog (94%); Rat, Hamster, Panda (89%).
Immunogen Type
Synthetic peptide
Immunogen
HELO1 / ELOVL5 antibody was raised against synthetic 18 amino acid peptide from internal region of human ELOVL5. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Elephant, Rabbit (100%); Marmoset, Mouse, Dog (94%); Rat, Hamster, Panda (89%); Bat (83%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-HELO1 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-HELO1 antibody
IHC-P (5 - 10 ug/ml)

Immunohistochemistry (IHC) of anti-HELO1 antibody

Anti-ELOVL5 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-HELO1 Polyclonal Antibody – Cat# MBS247862

Immunohistochemistry (IHC) of anti-HELO1 antibody

Anti-ELOVL5 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-HELO1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247862

Other Notes

Small volumes of anti-HELO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HELO1. It may not necessarily be applicable to this product.

NCBI GI #
11464975
NCBI GeneID
60481
NCBI Accession #
NP_068586.1
UniProt Primary Accession #
Q9NYP7
UniProt Secondary Accession #
Q59EL3; Q5TGH5; Q6NXE7; Q7L2S5; Q8NCG4; Q9UI22; B4DZJ2; F6SH78
UniProt Related Accession #
Q9NYP7
GenBank Nucleotide #
NM_021814.4
NCBI Official Full Name
elongation of very long chain fatty acids protein 5 isoform 1
NCBI Official Synonym Full Names
ELOVL fatty acid elongase 5
NCBI Official Symbol
ELOVL5
NCBI Official Synonym Symbols
HELO1; SCA38; dJ483K16.1
UniProt Protein Name
Elongation of very long chain fatty acids protein 5
UniProt Synonym Protein Names
3-keto acyl-CoA synthase ELOVL5; ELOVL fatty acid elongase 5; ELOVL FA elongase 5; Fatty acid elongase 1; hELO1; Very-long-chain 3-oxoacyl-CoA synthase 5
UniProt Gene Name
ELOVL5
UniProt Synonym Gene Names
ELOVL2; ELOVL FA elongase 5; hELO1
UniProt Entry Name
ELOV5_HUMAN
NCBI Protein Information
elongation of very long chain fatty acids protein 5; ELOVL FA elongase 5; fatty acid elongase 1; spinocerebellar ataxia 38; 3-keto acyl-CoA synthase ELOVL5; very-long-chain 3-oxoacyl-CoA synthase 5; homolog of yeast long chain polyunsaturated fatty acid elongation enzyme 2; ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)

NCBI Summary for HELO1

This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
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UniProt Comments for HELO1

ELOVL5: Condensing enzyme that catalyzes the synthesis of monounsaturated and of polyunsaturated very long chain fatty acids Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. Belongs to the ELO family.

Protein type: Membrane protein, integral; EC 2.3.1.199; Membrane protein, multi-pass; Lipid Metabolism - unsaturated fatty acid biosynthesis

Chromosomal Location of Human Ortholog: 6p12.1

Cellular Component: endoplasmic reticulum membrane; membrane; cell soma; endoplasmic reticulum; dendrite; integral to membrane

Molecular Function: protein binding; fatty acid elongase activity

Biological Process: unsaturated fatty acid metabolic process; very-long-chain fatty acid biosynthetic process; linoleic acid metabolic process; triacylglycerol biosynthetic process; unsaturated fatty acid biosynthetic process; cellular lipid metabolic process

Disease: Spinocerebellar Ataxia 38
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Research Articles on HELO1

1. In transfection experiments, subcellular localization of altered ELOVL5 showed a perinuclear distribution with a signal increase in the Golgi compartment, whereas the wild-type showed a widespread signal in the endoplasmic reticulum.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HELO1 antibody

 Reference Product  PubMed Publications
 FADS2 antibody  >23 publications with HELO1 and FADS2
 ELOVL2 antibody  >22 publications with HELO1 and ELOVL2
 FADS1 antibody  >15 publications with HELO1 and FADS1
 SCD antibody  >10 publications with HELO1 and SCD
 ELOVL6 antibody  >8 publications with HELO1 and ELOVL6
 SRBD1 antibody  >5 publications with HELO1 and SRBD1
 FASN antibody  >4 publications with HELO1 and FASN
 ELOVL3 antibody  >2 publications with HELO1 and ELOVL3

Pathways associated with anti-HELO1 antibody

 Products by Pathway  Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway antibodies  Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway Diagram
 Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway antibodies  Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway Diagram
 Fatty Acid Elongation Pathway antibodies  Fatty Acid Elongation Pathway Diagram
 Fatty Acid Elongation Pathway antibodies  Fatty Acid Elongation Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram

Diseases associated with anti-HELO1 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >31 publications with HELO1 and Fatty Liver
 Liver Diseases Antibodies  >7 publications with HELO1 and Liver Diseases
 Hyperglycemia Antibodies  >3 publications with HELO1 and Hyperglycemia
 Cardiovascular Diseases Antibodies  >2 publications with HELO1 and Cardiovascular Diseases
 Inflammation Antibodies  >2 publications with HELO1 and Inflammation
 Prostatic Diseases Antibodies  >2 publications with HELO1 and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >2 publications with HELO1 and Prostatic Neoplasms
 Glucose Intolerance Antibodies  >1 publications with HELO1 and Glucose Intolerance
 Weight Gain Antibodies  >1 publications with HELO1 and Weight Gain
 Hepatomegaly Antibodies  >1 publications with HELO1 and Hepatomegaly

Organs/Tissues associated with anti-HELO1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >32 publications with HELO1 and Liver
 Brain Antibodies  >13 publications with HELO1 and Brain
 Blood Antibodies  >12 publications with HELO1 and Blood
 Intestine Antibodies  >8 publications with HELO1 and Intestine
 Connective Tissue Antibodies  >5 publications with HELO1 and Connective Tissue
 Muscle Antibodies  >5 publications with HELO1 and Muscle
 Adipose Tissue Antibodies  >5 publications with HELO1 and Adipose Tissue
 Mammary Gland Antibodies  >2 publications with HELO1 and Mammary Gland
 Prostate Antibodies  >2 publications with HELO1 and Prostate
 Nerve Antibodies  >2 publications with HELO1 and Nerve
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