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PGES Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247884

Prostaglandin E Synthase (PGES) is a membrane associated protein involved in eicosanoid and glutathione metabolism as part of the arachidonic acid signaling pathway. The expression of PGES is induced by the proinflammatory cytokine IL-1B and its activity is… More details

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Product Overview

Online Datasheet in PDF
Product Name
PGES / PTGES, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human PGES / PTGES
Product Gene Name
anti-PGES antibody
Product Synonym Gene Name
PTGES
Product Synonym Names
Anti-PGES / PTGES Antibody (N-Terminus) IHC-plus; PTGES; MGST1-L1; MGST1-like 1; MPGES; MPGES-1; PGES; PIG12; PP102; TP53I12; MGST1L1; MPGES1; PP1294; MGST-IV; p53-induced gene 12 protein; Prostaglandin E synthase; Human PGES; PTGES
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human, Monkey, Mouse, Pig, Rabbit, Rat
Predicted Reactivity: Bovine, Hamster (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human PTGES. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.
Molecular Weight
17,102 Da
OMIM
605172
3D Structure
ModBase 3D Structure for O14684
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from N-Terminus of human PTGES. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Rabbit, Pig (100%); Hamster, Bovine (94%).
Immunogen Type
Synthetic peptide
Immunogen
PGES / PTGES antibody was raised against synthetic 16 amino acid peptide from N-Terminus of human PTGES. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Rabbit, Pig (100%); Hamster, Bovine (94%); Dog, Horse, Turkey, Chicken (88%); Pike (81%).
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-PGES antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-PGES antibody
IHC-P (5 ug/ml)

Immunohistochemistry (IHC) of anti-PGES antibody

Anti-PTGES antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-PGES Polyclonal Antibody – Cat# MBS247884

Other Notes

Small volumes of anti-PGES antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PGES purchase

MBS247884 is an antibody targeting PGES. Also known as Rabbit Polyclonal to Human PGES / PTGES. Reactive in Gibbon, Gorilla, Human, Monkey, Mouse, Pig, Rabbit, Rat
Predicted Reactivity: Bovine, Hamster (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PGES. It may not necessarily be applicable to this product.

NCBI GI #
4758910
NCBI GeneID
9536
NCBI Accession #
NP_004869.1
UniProt Primary Accession #
O14684
UniProt Secondary Accession #
O14900; Q5SZC0
UniProt Related Accession #
O14684
GenBank Nucleotide #
NM_004878.4
NCBI Official Full Name
prostaglandin E synthase
NCBI Official Synonym Full Names
prostaglandin E synthase
NCBI Official Symbol
PTGES
NCBI Official Synonym Symbols
PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1
UniProt Protein Name
Prostaglandin E synthase
UniProt Synonym Protein Names
Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
UniProt Gene Name
PTGES
UniProt Synonym Gene Names
MGST1L1; MPGES1; PGES; PIG12; MGST1-L1; MPGES-1
UniProt Entry Name
PTGES_HUMAN
NCBI Protein Information
prostaglandin E synthase; MGST1-like 1; p53-induced gene 12 protein; p53-induced apoptosis protein 12; glutathione S-transferase 1-like 1; microsomal prostaglandin E synthase 1; microsomal prostaglandin E synthase-1; tumor protein p53 inducible protein 12; microsomal glutathione S-transferase 1-like 1

NCBI Summary for PGES

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]
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UniProt Comments for PGES

PTGES: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Belongs to the MAPEG family.

Protein type: Membrane protein, multi-pass; Isomerase; Nuclear envelope; Lipid Metabolism - arachidonic acid; EC 5.3.99.3; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: endoplasmic reticulum membrane; membrane; nuclear envelope lumen; perinuclear region of cytoplasm; integral to membrane

Molecular Function: glutathione binding; prostaglandin-E synthase activity

Biological Process: negative regulation of cell proliferation; chronic inflammatory response; response to retinoic acid; response to cytokine stimulus; cyclooxygenase pathway; arachidonic acid metabolic process; response to lipopolysaccharide; signal transduction; prostaglandin biosynthetic process; response to calcium ion; response to organic cyclic substance; acute inflammatory response; prostaglandin metabolic process
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Research Articles on PGES

1. Data indicate that the Tibetan prolyl hydroxylase domain protein 2 (PHD2) haplotype (D4E/C127S) strikingly diminishes the interaction of PHD2 with heat shock protein 90 co-chaperone protein p23 (prostaglandin E synthase).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PGES antibody

 Reference Product  PubMed Publications
 PTGS2 antibody  >46 publications with PGES and PTGS2
 PTGS1 antibody  >14 publications with PGES and PTGS1
 PTGIS antibody  >8 publications with PGES and PTGIS
 PTGES2 antibody  >7 publications with PGES and PTGES2
 IL1B antibody  >4 publications with PGES and IL1B
 PTGDS antibody  >4 publications with PGES and PTGDS
 TBXAS1 antibody  >3 publications with PGES and TBXAS1
 CBR1 antibody  >2 publications with PGES and CBR1
 HPGDS antibody  >1 publications with PGES and HPGDS

Pathways associated with anti-PGES antibody

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway antibodies  Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway Diagram

Diseases associated with anti-PGES antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >33 publications with PGES and Inflammation
 Necrosis Antibodies  >10 publications with PGES and Necrosis
 Disease Models, Animal Antibodies  >8 publications with PGES and Disease Models, Animal
 Nervous System Diseases Antibodies  >7 publications with PGES and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >5 publications with PGES and Cardiovascular Diseases
 Pain Antibodies  >4 publications with PGES and Pain
 Breast Neoplasms Antibodies  >3 publications with PGES and Breast Neoplasms
 Weight Loss Antibodies  >3 publications with PGES and Weight Loss
 Fever Antibodies  >3 publications with PGES and Fever
 Adenocarcinoma Antibodies  >3 publications with PGES and Adenocarcinoma

Organs/Tissues associated with anti-PGES antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with PGES and Brain
 Uterus Antibodies  >11 publications with PGES and Uterus
 Bone Antibodies  >8 publications with PGES and Bone
 Ovary Antibodies  >4 publications with PGES and Ovary
 Liver Antibodies  >4 publications with PGES and Liver
 Connective Tissue Antibodies  >4 publications with PGES and Connective Tissue
 Lung Antibodies  >4 publications with PGES and Lung
 Placenta Antibodies  >3 publications with PGES and Placenta
 Kidney Antibodies  >2 publications with PGES and Kidney
 Intestine Antibodies  >2 publications with PGES and Intestine
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