Rabbit Anti-OPRK1 Polyclonal Antibody – Cat# MBS247940

Anti-Kappa Opioid Receptor antibody IHC of rat brain, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

OPRK1 Antibody – Rabbit Polyclonal

Name: OPRK1 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS247940
Price: 630 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247940

KOR1, an Opioid Receptor, plays a modulatory role in specific aspects of opioid function such as the control of pain. Its endogenous ligand, dynorphin A, is an important neurotransmitter in the central and peripheral nervous systems. KOR1 is believed to… More details

$630 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

OPRK1 / Kappa Opioid Receptor, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human OPRK1 / Kappa Opioid Receptor

Product Gene Name

anti-OPRK1 antibody

Product Synonym Names

Anti-OPRK1 / Kappa Opioid Receptor Antibody (Extracellular Domain) IHC-plus; OPRK1; Kappa-type opioid receptor; Opiate receptor; kappa-1; K-OR-1; KOR; Opioid receptor; kappa 1; OPRK; Ork1; Kappa opioid receptor; KOR-1; Opioid receptor kappa; Human OPRK1; Kappa Opioid Receptor

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Gibbon, Dog, Horse, Human, Monkey, Rabbit, Rat
Predicted Reactivity: Gorilla, Mouse, Guinea pig (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human Kappa Opioid Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

33,319 Da

OMIM

165196

3D Structure

ModBase 3D Structure for P41145

Target Species

Human

Immunogen Description

Synthetic 19 amino acid peptide from 2nd extracellular domain of human Kappa Opioid Receptor. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Dog, Horse, Rabbit (100%).

Immunogen Type

Synthetic peptide

Immunogen

OPRK1 / Kappa Opioid Receptor antibody was raised against synthetic 19 amino acid peptide from 2nd extracellular domain of human Kappa Opioid Receptor. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Dog, Horse, Rabbit (100%); Gorilla, Mouse, Rat, Elephant, Guinea pig (95%); Bat, Bovine, Panda (89%); Opossum (84%).

Antigen Modification

Extracellular Domain

Product Categories/Family for anti-OPRK1 antibody

Family: GPCR; Subfamily: Opioid

Applications Tested/Suitable for anti-OPRK1 antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-OPRK1 antibody

IHC-P (4 ug/ml)

Other Notes

Small volumes of anti-OPRK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OPRK1 purchase

MBS247940 is an antibody targeting OPRK1. Also known as Rabbit Polyclonal to Human OPRK1 / Kappa Opioid Receptor. Reactive in Gibbon, Dog, Horse, Human, Monkey, Rabbit, Rat
Predicted Reactivity: Gorilla, Mouse, Guinea pig (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OPRK1. It may not necessarily be applicable to this product.

NCBI GI #

39725940

NCBI GeneID

4986

NCBI Accession #

NP_000903.2

UniProt Primary Accession #

P41145

UniProt Secondary Accession #

Q499G4; E5RHC9

UniProt Related Accession #

P41145

GenBank Nucleotide #

NM_000912.3

NCBI Official Full Name

kappa-type opioid receptor isoform 1

NCBI Official Synonym Full Names

opioid receptor, kappa 1

NCBI Official Symbol

OPRK1

NCBI Official Synonym Symbols

KOR; OPRK; KOR-1; K-OR-1

UniProt Protein Name

Kappa-type opioid receptor

Protein Family

Kappa-type opioid receptor

UniProt Gene Name

OPRK1

UniProt Synonym Gene Names

OPRK; K-OR-1; KOR-1

UniProt Entry Name

OPRK_HUMAN

NCBI Protein Information

kappa-type opioid receptor; kappa opioid receptor; Opiate receptor, kappa-1

UniProt Comments for OPRK1

KOR-1: kappa-type opioid receptor. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for dynorphins. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 8q11.2

Cellular Component: neuron projection; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: neuropeptide binding; protein binding; opioid receptor activity

Biological Process: synaptic transmission; neuropeptide signaling pathway; sensory perception; behavior; opioid receptor, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); locomotory behavior; immune response; regulation of saliva secretion; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain; defense response to virus

Research Articles on OPRK1

1. Data indicate that replacement of the 3-hydroxyl substituent of the 4-(3-hydroxyphenyl) group of JDTic with a H, F, or Cl substituent leads to potent and selective kappa opioid receptor (KOR) antagonists.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OPRK1 antibody

Reference Product	PubMed Publications
OPRD1 antibody	>23 publications with OPRK1 and OPRD1
PDYN antibody	>13 publications with OPRK1 and PDYN
POMC antibody	>3 publications with OPRK1 and POMC
PENK antibody	>2 publications with OPRK1 and PENK

Pathways associated with anti-OPRK1 antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-OPRK1 antibody

Disease Name	Pubmed Publications
Substance-Related Disorders Antibodies	>20 publications with OPRK1 and Substance-Related Disorders
Pain Antibodies	>13 publications with OPRK1 and Pain
Nervous System Diseases Antibodies	>7 publications with OPRK1 and Nervous System Diseases
Cocaine-Related Disorders Antibodies	>4 publications with OPRK1 and Cocaine-Related Disorders
Disease Models, Animal Antibodies	>3 publications with OPRK1 and Disease Models, Animal
Substance Withdrawal Syndrome Antibodies	>2 publications with OPRK1 and Substance Withdrawal Syndrome
Anxiety Disorders Antibodies	>2 publications with OPRK1 and Anxiety Disorders
Inflammation Antibodies	>2 publications with OPRK1 and Inflammation
Neurobehavioral Manifestations Antibodies	>1 publications with OPRK1 and Neurobehavioral Manifestations
Cognition Disorders Antibodies	>1 publications with OPRK1 and Cognition Disorders

Organs/Tissues associated with anti-OPRK1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>21 publications with OPRK1 and Brain
Prostate Antibodies	>2 publications with OPRK1 and Prostate
Muscle Antibodies	>1 publications with OPRK1 and Muscle