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ZGPAT Antibody – Chicken Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247993

MBS247993 is an antibody targeting ZGPAT. Also known as Chicken Polyclonal (IgY) to Human ZGPAT. Reactive in Human. Host: Chicken. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ZGPAT, Polyclonal Antibody
Full Product Name
Chicken Polyclonal (IgY) to Human ZGPAT
Product Gene Name
anti-ZGPAT antibody
Product Synonym Names
Anti-ZGPAT Antibody (C-Terminus) IHC-plus; ZGPAT; DJ583P15.3; GPATC6; KIAA1847; RP4-583P15.3; ZC3HDC9; ZIP; ZC3H9; GPATCH6; Human ZGPAT
Clonality
Polyclonal
Isotype
IgY
Host
Chicken
Species Reactivity
Human
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human ZGPAT. Multiple isoforms of ZGPAT are known to exist.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
20,697 Da
3D Structure
ModBase 3D Structure for Q8N5A5
Target Species
Human
Immunogen Description
A 15 amino acid peptide near the carboxy terminus of human ZGPAT
Immunogen Type
Synthetic peptide
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-ZGPAT antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-ZGPAT antibody
ELISA, IF (20 ug/ml), IHC-P (5 ug/ml), WB (1 ug/ml)

Immunohistochemistry (IHC) of anti-ZGPAT antibody

Anti-ZGPAT antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Chicken Anti-ZGPAT Polyclonal Antibody – Cat# MBS247993

Immunofluorescence (IF) of anti-ZGPAT antibody

Immunofluorescence of ZGPAT in human brain cells with ZGPAT antibody at 20 µg/mL.
Chicken Anti-ZGPAT Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS247993

Western Blot (WB) of anti-ZGPAT antibody

Western blot analysis of ZGPAT in SK-N-SH cell lysate with ZGPAT antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Chicken Anti-ZGPAT Polyclonal Antibody, Western Blot (WB) – Cat# MBS247993

Other Notes

Small volumes of anti-ZGPAT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ZGPAT. It may not necessarily be applicable to this product.

NCBI GI #
133925795
NCBI GeneID
84619
NCBI Accession #
NP_001076582.1
UniProt Primary Accession #
Q8N5A5
UniProt Secondary Accession #
Q4VXN9; Q5JWI9; Q5JWJ0; Q8NC55; Q8WUV4; Q96JI0; Q96JU4; Q9H401; E1P5K1
UniProt Related Accession #
Q8N5A5
GenBank Nucleotide #
NM_001083113.1
NCBI Official Full Name
zinc finger CCCH-type with G patch domain-containing protein isoform c
NCBI Official Synonym Full Names
zinc finger, CCCH-type with G patch domain
NCBI Official Symbol
ZGPAT
NCBI Official Synonym Symbols
ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847
UniProt Protein Name
Zinc finger CCCH-type with G patch domain-containing protein
UniProt Synonym Protein Names
G patch domain-containing protein 6; Zinc finger CCCH domain-containing protein 9; Zinc finger and G patch domain-containing protein
UniProt Gene Name
ZGPAT
UniProt Synonym Gene Names
GPATC6; GPATCH6; KIAA1847; ZC3H9; ZC3HDC9; ZIP
UniProt Entry Name
ZGPAT_HUMAN
NCBI Protein Information
zinc finger CCCH-type with G patch domain-containing protein; g patch domain-containing protein 6; zinc finger CCCH domain-containing protein 9; zinc finger and G patch domain-containing protein

UniProt Comments for ZGPAT

ZGPAT: Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding; metal ion binding; transcription factor activity

Biological Process: negative regulation of epidermal growth factor receptor activity; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
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Research Articles on ZGPAT

1. sZIP, an alternative splice variant of ZIP, antagonizes transcription repression and growth inhibition by ZIP in liver neoplasms.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-ZGPAT antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >2 publications with ZGPAT and Skin
 Brain Antibodies  >2 publications with ZGPAT and Brain
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