ELK3 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. [provided by RefSeq, Jul 2008]

ELK3: a transcription factor of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. May be a negative regulator of transcription but can activate transcription when co expressed with Ras, Src or Mos. Activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 12q23

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; mitochondrion; nucleus

Molecular Function: protein binding; transcription corepressor activity; transcription factor activity; purine-rich negative regulatory element binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; wound healing; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; negative regulation of transcription, DNA-dependent; signal transduction; cell differentiation