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LRPAP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248005

MBS248005 is an antibody targeting LRPAP1. Also known as Rabbit Polyclonal (IgG) to Human LRPAP1. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
LRPAP1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human LRPAP1
Product Gene Name
anti-LRPAP1 antibody
Product Synonym Names
Anti-LRPAP1 Antibody IHC-plus; LRPAP1; A2MRAP; Alpha-2-MRAP; A2RAP; HBP44; RAP; Human LRPAP1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human LRPAP1
Preparation and Storage
Aliquot and freeze at -20 degree C. Avoid freeze-thaw cycles.
Molecular Weight
41,466 Da
OMIM
gene 615431
3D Structure
ModBase 3D Structure for P30533
Target Species
Human
Immunogen Description
Recombinant fragment corresponding to a region within amino acids 31 and 325 of RAP (SwissProt P30533). Percent identity by BLAST analysis:
Immunogen Type
Recombinant protein
Applications Tested/Suitable for anti-LRPAP1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-LRPAP1 antibody
IHC-P (7.5 ug/ml), WB (1:500 - 1:3000)
Usage: Suggested starting dilutions are as follows: Western blot: 1:500-1:3000. IHC-Paraffin: 7.5 ug/ml. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Immunohistochemistry (IHC) of anti-LRPAP1 antibody

Anti-LRPAP1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 7.5 ug/ml.
Rabbit Anti-LRPAP1 Polyclonal Antibody – Cat# MBS248005

Western Blot (WB) of anti-LRPAP1 antibody

Sample (30 ug of whole cell lysate) A: HeLa B: HepG2 10% SDS PAGE LRPAP1 antibody diluted at 1:1000
Rabbit Anti-LRPAP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248005

Other Notes

Small volumes of anti-LRPAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LRPAP1. It may not necessarily be applicable to this product.

NCBI GI #
4505021
NCBI GeneID
4043
NCBI Accession #
NP_002328.1
UniProt Primary Accession #
P30533
UniProt Secondary Accession #
Q2M310; Q53HQ3; Q53HS6; D3DVR9
UniProt Related Accession #
P30533
GenBank Nucleotide #
NM_002337.3
NCBI Official Full Name
alpha-2-macroglobulin receptor-associated protein
NCBI Official Synonym Full Names
low density lipoprotein receptor-related protein associated protein 1
NCBI Official Symbol
LRPAP1
NCBI Official Synonym Symbols
RAP; MRAP; A2RAP; HBP44; MYP23; A2MRAP; alpha-2-MRAP
UniProt Protein Name
Alpha-2-macroglobulin receptor-associated protein
UniProt Synonym Protein Names
Low density lipoprotein receptor-related protein-associated protein 1; RAP
Protein Family
Alpha-2-macroglobulin receptor-associated protein
UniProt Gene Name
LRPAP1
UniProt Synonym Gene Names
A2MRAP; Alpha-2-MRAP; RAP
UniProt Entry Name
AMRP_HUMAN
NCBI Protein Information
alpha-2-macroglobulin receptor-associated protein; 39 kDa receptor-associated protein; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)

NCBI Summary for LRPAP1

This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
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UniProt Comments for LRPAP1

LRPAP1: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis. Belongs to the alpha-2-MRAP family.

Protein type: Receptor, misc.

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: cell surface; endoplasmic reticulum; integral to membrane; extracellular region; plasma membrane; vesicle

Molecular Function: heparin binding; protein binding; receptor antagonist activity; low-density lipoprotein receptor binding; unfolded protein binding; asialoglycoprotein receptor activity

Biological Process: vesicle-mediated transport; receptor-mediated endocytosis; protein folding; negative regulation of protein binding

Disease: Myopia 23, Autosomal Recessive
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Research Articles on LRPAP1

1. RAP inhibited light chain (LC)endocytosis by approximately 88% and ameliorated LC-induced cytokine responses and epithelial-to-mesenchymal transformation in human proximal tubular cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LRPAP1 antibody

 Reference Product  PubMed Publications
 LRP1 antibody  >5 publications with LRPAP1 and LRP1
 LRP2 antibody  >2 publications with LRPAP1 and LRP2
 VLDLR antibody  >2 publications with LRPAP1 and VLDLR
 LRP8 antibody  >1 publications with LRPAP1 and LRP8

Pathways associated with anti-LRPAP1 antibody

 Products by Pathway  Pathway Diagram
 Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies  Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram
 Reelin Signaling Pathway antibodies  Reelin Signaling Pathway Diagram
 Signaling Events Mediated By The Hedgehog Family Pathway antibodies  Signaling Events Mediated By The Hedgehog Family Pathway Diagram

Diseases associated with anti-LRPAP1 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >6 publications with LRPAP1 and Brain Diseases
 Atherosclerosis Antibodies  >3 publications with LRPAP1 and Atherosclerosis
 Neurobehavioral Manifestations Antibodies  >2 publications with LRPAP1 and Neurobehavioral Manifestations
 Chromosome Aberrations Antibodies  >1 publications with LRPAP1 and Chromosome Aberrations
 Disease Models, Animal Antibodies  >1 publications with LRPAP1 and Disease Models, Animal
 Cognition Disorders Antibodies  >1 publications with LRPAP1 and Cognition Disorders
 Weight Loss Antibodies  >1 publications with LRPAP1 and Weight Loss
 Prenatal Injuries Antibodies  >1 publications with LRPAP1 and Prenatal Injuries
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with LRPAP1 and Prenatal Exposure Delayed Effects

Organs/Tissues associated with anti-LRPAP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with LRPAP1 and Blood
 Liver Antibodies  >4 publications with LRPAP1 and Liver
 Brain Antibodies  >3 publications with LRPAP1 and Brain
 Kidney Antibodies  >2 publications with LRPAP1 and Kidney
 Bone Antibodies  >2 publications with LRPAP1 and Bone
 Vascular Antibodies  >2 publications with LRPAP1 and Vascular
 Heart Antibodies  >2 publications with LRPAP1 and Heart
 Spleen Antibodies  >1 publications with LRPAP1 and Spleen
 Bladder Antibodies  >1 publications with LRPAP1 and Bladder
 Ovary Antibodies  >1 publications with LRPAP1 and Ovary
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