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TSTA3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248011

MBS248011 is an antibody targeting TSTA3. Also known as Rabbit Polyclonal (IgG) to Human TSTA3 / FX. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TSTA3 / FX, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human TSTA3 / FX
Product Gene Name
anti-TSTA3 antibody
Product Synonym Gene Name
FX
Product Synonym Names
Anti-TSTA3 / FX Antibody (aa221-270) IHC-plus; TSTA3; 3-5 epimerase/4-reductase; FX; GDP-L-fucose synthase; SDR4E1; p35B; Protein FX; Human TSTA3; FX
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
TSTA3 Antibody detects endogenous levels of total TSTA3 protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
35,893 Da
OMIM
137020
3D Structure
ModBase 3D Structure for Q13630
Target Species
Human
Immunogen Description
Synthetic peptide from human TSTA3 (aa221-270).
Immunogen
TSTA3 / FX antibody was raised against synthetic peptide from human TSTA3 (aa221-270).
Antigen Modification
aa221-270
Applications Tested/Suitable for anti-TSTA3 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-TSTA3 antibody
ELISA (1:1000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-TSTA3 antibody

Anti-TSTA3 / FX antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-TSTA3 Polyclonal Antibody – Cat# MBS248011

Western Blot (WB) of anti-TSTA3 antibody

Western blot of extracts from rat kidney/rat muscle cells, using TSTA3 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-TSTA3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248011

Other Notes

Small volumes of anti-TSTA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TSTA3. It may not necessarily be applicable to this product.

NCBI GI #
4507709
NCBI GeneID
7264
NCBI Accession #
NP_003304.1
UniProt Primary Accession #
Q13630
UniProt Secondary Accession #
Q567Q9; Q9UDG7; B2R8Y7; D3DWK5
UniProt Related Accession #
Q13630
GenBank Nucleotide #
NM_003313.3
NCBI Official Full Name
GDP-L-fucose synthase
NCBI Official Synonym Full Names
tissue specific transplantation antigen P35B
NCBI Official Symbol
TSTA3
NCBI Official Synonym Symbols
FX; P35B; SDR4E1
UniProt Protein Name
GDP-L-fucose synthase
UniProt Synonym Protein Names
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; Protein FX; Red cell NADP(H)-binding protein; Short-chain dehydrogenase/reductase family 4E member 1
UniProt Gene Name
TSTA3
UniProt Synonym Gene Names
SDR4E1
UniProt Entry Name
FCL_HUMAN
NCBI Protein Information
GDP-L-fucose synthase; 3-5 epimerase/4-reductase; red cell NADP(H)-binding protein; tissue specific transplantation antigen 3; GDP-4-keto-6-deoxy-D-mannose epimerase-reductase; GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase; short chain dehydrogenase/reductase family 4E, member 1

NCBI Summary for TSTA3

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]
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UniProt Comments for TSTA3

TSTA3: Two step NADP-dependent conversion of GDP-4-dehydro-6- deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. Belongs to the fucose synthase family.

Protein type: Oxidoreductase; EC 1.1.1.271; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - amino sugar and nucleotide sugar

Chromosomal Location of Human Ortholog: 8q24.3

Cellular Component: cytoplasm

Molecular Function: GDP-L-fucose synthase activity; electron carrier activity; isomerase activity; coenzyme binding; GDP-4-dehydro-D-rhamnose reductase activity

Biological Process: leukocyte adhesion; cytolysis; GDP-mannose metabolic process; 'de novo' GDP-L-fucose biosynthetic process
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Research Articles on TSTA3

1. Data indicate that the structure of GDP-l-fucose synthase (FX) reveals the key catalytic residues.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TSTA3 antibody

 Products by Pathway  Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 GDP-L-fucose Biosynthesis I (from GDP-D-mannose) Pathway antibodies  GDP-L-fucose Biosynthesis I (from GDP-D-mannose) Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram

Diseases associated with anti-TSTA3 antibody

 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >3 publications with TSTA3 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >3 publications with TSTA3 and Liver Diseases
 Anemia Antibodies  >2 publications with TSTA3 and Anemia
 Adenocarcinoma Antibodies  >2 publications with TSTA3 and Adenocarcinoma
 Hepatitis Antibodies  >2 publications with TSTA3 and Hepatitis
 Fibrosis Antibodies  >1 publications with TSTA3 and Fibrosis
 Liver Cirrhosis Antibodies  >1 publications with TSTA3 and Liver Cirrhosis
 Nervous System Diseases Antibodies  >1 publications with TSTA3 and Nervous System Diseases
 Breast Neoplasms Antibodies  >1 publications with TSTA3 and Breast Neoplasms
 Congenital Abnormalities Antibodies  >1 publications with TSTA3 and Congenital Abnormalities

Organs/Tissues associated with anti-TSTA3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with TSTA3 and Blood
 Liver Antibodies  >2 publications with TSTA3 and Liver
 Parathyroid Antibodies  >1 publications with TSTA3 and Parathyroid
 Eye Antibodies  >1 publications with TSTA3 and Eye
 Lung Antibodies  >1 publications with TSTA3 and Lung
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