• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

PTGIR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248047

The prostacyclin receptor (IP), a Prostanoid Receptor, mediates the effects of prostacyclin, a potent mediator of vasodilation and inhibitor of platelet aggregation. More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
PTGIR / IP Receptor, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human PTGIR / IP Receptor
Product Gene Name
anti-PTGIR antibody
Product Synonym Names
Anti-PTGIR / IP Receptor Antibody (aa188-237) IHC-plus; PTGIR; IP receptor; PGI receptor; PRIPR; Prostaglandin I2 receptor; IP; PGI2 receptor; Prostacyclin IP receptor; Prostacyclin receptor; Prostanoid IP receptor; Human PTGIR; IP Receptor
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Prostacyclin Receptor Antibodyantibody detects endogenous levels of Prostacyclin Receptor.
Preparation and Storage
Store at -20 degree C.
Molecular Weight
40,956 Da
OMIM
600022
3D Structure
ModBase 3D Structure for P43119
Target Species
Human
Immunogen Description
Synthetic peptide from human Prostacyclin Receptor (aa188-237).
Immunogen
PTGIR / IP Receptor antibody was raised against synthetic peptide from human Prostacyclin Receptor (aa188-237).
Antigen Modification
aa188-237

Product Categories/Family for anti-PTGIR antibody

Family: GPCR; Subfamily: Prostanoid
Applications Tested/Suitable for anti-PTGIR antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-PTGIR antibody
ELISA (1:10000), IHC-P (20 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-PTGIR antibody

Anti-PTGIR / IP Receptor antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Rabbit Anti-PTGIR Polyclonal Antibody – Cat# MBS248047

Western Blot (WB) of anti-PTGIR antibody

Western blot of the lysates from HUVEC cells using Prostacyclin Receptor antibody.
Rabbit Anti-PTGIR Polyclonal Antibody, Western Blot (WB) – Cat# MBS248047

Other Notes

Small volumes of anti-PTGIR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTGIR purchase

MBS248047 is an antibody targeting PTGIR. Also known as Rabbit Polyclonal (IgG) to Human PTGIR / IP Receptor. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTGIR. It may not necessarily be applicable to this product.

NCBI GI #
4506263
NCBI GeneID
5739
NCBI Accession #
NP_000951.1
UniProt Primary Accession #
P43119
UniProt Related Accession #
P43119
GenBank Nucleotide #
NM_000960.3
NCBI Official Full Name
prostacyclin receptor
NCBI Official Synonym Full Names
prostaglandin I2 (prostacyclin) receptor (IP)
NCBI Official Symbol
PTGIR
NCBI Official Synonym Symbols
IP; PRIPR
UniProt Protein Name
Prostacyclin receptor
UniProt Synonym Protein Names
Prostaglandin I2 receptor; PGI receptor; PGI2 receptor; Prostanoid IP receptor
Protein Family
Prostacyclin receptor
UniProt Gene Name
PTGIR
UniProt Synonym Gene Names
PRIPR; PGI receptor; PGI2 receptor
UniProt Entry Name
PI2R_HUMAN
NCBI Protein Information
prostacyclin receptor; PGI receptor; PGI2 receptor; prostanoid IP receptor; prostaglandin I2 receptor

NCBI Summary for PTGIR

The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for PTGIR

PTGIR: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: integral to plasma membrane; plasma membrane; cytosol

Molecular Function: G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; cell-cell signaling; negative regulation of smooth muscle cell proliferation; positive regulation of cAMP biosynthetic process; response to lipopolysaccharide; blood coagulation; G-protein signaling, adenylate cyclase activating pathway; positive regulation of GTPase activity
Show more

Research Articles on PTGIR

1. Prostaglandin I2- Prostaglandin I2 receptor signaling regulates human Th17 and Treg cell differentiation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTGIR antibody

 Reference Product  PubMed Publications
 PTGER4 antibody  >5 publications with PTGIR and PTGER4
 ADRB2 antibody  >3 publications with PTGIR and ADRB2

Pathways associated with anti-PTGIR antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Eicosanoid Ligand-binding Receptors Pathway antibodies  Eicosanoid Ligand-binding Receptors Pathway Diagram
 Endothelin Pathway antibodies  Endothelin Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with anti-PTGIR antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >17 publications with PTGIR and Cardiovascular Diseases
 Vascular Diseases Antibodies  >14 publications with PTGIR and Vascular Diseases
 Inflammation Antibodies  >13 publications with PTGIR and Inflammation
 Hypertension Antibodies  >11 publications with PTGIR and Hypertension
 Disease Models, Animal Antibodies  >7 publications with PTGIR and Disease Models, Animal
 Atherosclerosis Antibodies  >6 publications with PTGIR and Atherosclerosis
 Pain Antibodies  >5 publications with PTGIR and Pain
 Lung Diseases Antibodies  >4 publications with PTGIR and Lung Diseases
 Heart Diseases Antibodies  >4 publications with PTGIR and Heart Diseases
 Necrosis Antibodies  >3 publications with PTGIR and Necrosis

Organs/Tissues associated with anti-PTGIR antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >35 publications with PTGIR and Vascular
 Blood Antibodies  >23 publications with PTGIR and Blood
 Kidney Antibodies  >8 publications with PTGIR and Kidney
 Lung Antibodies  >5 publications with PTGIR and Lung
 Skin Antibodies  >2 publications with PTGIR and Skin
 Embryonic Tissue Antibodies  >2 publications with PTGIR and Embryonic Tissue
 Brain Antibodies  >1 publications with PTGIR and Brain
 Connective Tissue Antibodies  >1 publications with PTGIR and Connective Tissue
 Spleen Antibodies  >1 publications with PTGIR and Spleen
 Eye Antibodies  >1 publications with PTGIR and Eye
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000