ZAK Antibody – Rabbit Polyclonal

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

ZAK: a mixed-lineage kinase containing a leucine-zipper (LZ) and a sterile-alpha motif (SAM). It is reported to activate the JNK/SAPK and NF-kappaB pathways.

Protein type: Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; TKL group; MLK family; MLK subfamily

Chromosomal Location of Human Ortholog: 2q24.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP binding

Biological Process: cell death; activation of MAPKK activity; positive regulation of apoptosis; cytoskeleton organization and biogenesis; protein amino acid phosphorylation; activation of JNK activity; cell proliferation; response to radiation; DNA damage checkpoint; response to stress; cell cycle arrest; cell differentiation; cell cycle checkpoint