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ENTPD5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248131

ENTPD5 is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. More details

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Product Overview

Product Name
ENTPD5 / CD39L4, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human ENTPD5 / CD39L4
Product Gene Name
anti-ENTPD5 antibody
Product Synonym Gene Name
CD39L4
Product Synonym Names
Anti-ENTPD5 / CD39L4 Antibody IHC-plus; ENTPD5; CD39L4; CD39 antigen-like 4; CD39-like 4; GDPase ENTPD5; PCPH; NTPDase 5; Nucleoside diphosphatase; UDPase ENTPD5; ER-UDPase; Guanosine-diphosphatase ENTPD5; NTPDase-5; Pcph proto-oncogene protein; Proto-oncogene CPH; Uridine-diphosphatase ENTPD5; Human ENTPD5; CD39L4
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
0.1 M Tris-glycine, pH 7, 10% Glycerol, 0.01% Thimerosal
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human ENTPD5. Predicted cross-reactivity based on amino acid sequence homology: mouse (88%), rat (86%).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
47,517 Da
OMIM
603162
3D Structure
ModBase 3D Structure for O75356
Target Species
Human
Immunogen Description
Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1 and 191 of Human ENTPD5
Immunogen Type
Recombinant protein
Applications Tested/Suitable for anti-ENTPD5 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-ENTPD5 antibody
IHC-P (10 ug/ml), WB (1:500 - 1:3000)

Immunohistochemistry (IHC) of anti-ENTPD5 antibody

Anti-ENTPD5 / CD39L4 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-ENTPD5 Polyclonal Antibody – Cat# MBS248131

Western Blot (WB) of anti-ENTPD5 antibody

Sample (30 ug of whole cell lysate). A: A431. B: H1299. C: Hela. 10% SDS PAGE. ENTPD5 antibody diluted at 1:1000.
Rabbit Anti-ENTPD5 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248131

Other Notes

Small volumes of anti-ENTPD5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ENTPD5 purchase

MBS248131 is an antibody targeting ENTPD5. Also known as Rabbit Polyclonal to Human ENTPD5 / CD39L4. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ENTPD5. It may not necessarily be applicable to this product.

NCBI GI #
4557427
NCBI GeneID
957
NCBI Accession #
NP_001240.1
UniProt Primary Accession #
O75356
UniProt Secondary Accession #
Q96RX0; A1L4C5
UniProt Related Accession #
O75356
GenBank Nucleotide #
NM_001249.2
NCBI Official Full Name
ectonucleoside triphosphate diphosphohydrolase 5
NCBI Official Synonym Full Names
ectonucleoside triphosphate diphosphohydrolase 5
NCBI Official Symbol
ENTPD5
NCBI Official Synonym Symbols
PCPH; CD39L4; NTPDase-5
UniProt Protein Name
Ectonucleoside triphosphate diphosphohydrolase 5
UniProt Synonym Protein Names
CD39 antigen-like 4; ER-UDPase; Guanosine-diphosphatase ENTPD5 (EC:3.6.1.42); GDPase ENTPD5; Nucleoside diphosphatase; Uridine-diphosphatase ENTPD5; UDPase ENTPD5
Protein Family
Ectonucleoside triphosphate diphosphohydrolase
UniProt Gene Name
ENTPD5
UniProt Synonym Gene Names
CD39L4; PCPH; NTPDase 5; GDPase ENTPD5; UDPase ENTPD5
UniProt Entry Name
ENTP5_HUMAN
NCBI Protein Information
ectonucleoside triphosphate diphosphohydrolase 5; ER-UDPase; NTPDase 5; CD39-like 4; GDPase ENTPD5; UDPase ENTPD5; proto-oncogene CPH; CD39 antigen-like 4; nucleoside diphosphatase; Pcph proto-oncogene protein; uridine-diphosphatase ENTPD5; guanosine-diphosphatase ENTPD5

NCBI Summary for ENTPD5

The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]

UniProt Comments for ENTPD5

ENTPD5: Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. Also hydrolyzes GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling. Belongs to the GDA1/CD39 NTPase family.

Protein type: Nucleotide Metabolism - purine; EC 3.6.1.6; EC 3.6.1.42; Oncoprotein; Nucleotide Metabolism - pyrimidine; Hydrolase

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: endoplasmic reticulum

Molecular Function: guanosine-diphosphatase activity; uridine-diphosphatase activity

Biological Process: ATP metabolic process; cell proliferation; 'de novo' posttranslational protein folding; positive regulation of glycolysis; regulation of phosphoinositide 3-kinase cascade; protein amino acid N-linked glycosylation; cell growth
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Research Articles on ENTPD5

1. These results strongly suggest that the mt-PCPH ( ENTPD5)oncoprotein may regulate the cellular energy levels and subsequent chemoresistance by an NTPDase-independent mechanism

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ENTPD5 antibody

 Reference Product  PubMed Publications
 ENTPD3 antibody  >1 publications with ENTPD5 and ENTPD3
 ENTPD1 antibody  >1 publications with ENTPD5 and ENTPD1

Pathways associated with anti-ENTPD5 antibody

 Products by Pathway  Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram

Diseases associated with anti-ENTPD5 antibody

 Disease Name  Pubmed Publications
 Liver Neoplasms Antibodies  >4 publications with ENTPD5 and Liver Neoplasms
 Disease Models, Animal Antibodies  >2 publications with ENTPD5 and Disease Models, Animal
 Lung Neoplasms Antibodies  >2 publications with ENTPD5 and Lung Neoplasms
 Liver Diseases Antibodies  >2 publications with ENTPD5 and Liver Diseases
 Adenoma, Liver Cell Antibodies  >1 publications with ENTPD5 and Adenoma, Liver Cell
 Brain Diseases Antibodies  >1 publications with ENTPD5 and Brain Diseases
 Hypertrophy Antibodies  >1 publications with ENTPD5 and Hypertrophy
 Nervous System Diseases Antibodies  >1 publications with ENTPD5 and Nervous System Diseases
 Hyperplasia Antibodies  >1 publications with ENTPD5 and Hyperplasia
 Liver Neoplasms, Experimental Antibodies  >1 publications with ENTPD5 and Liver Neoplasms, Experimental

Organs/Tissues associated with anti-ENTPD5 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with ENTPD5 and Liver
 Blood Antibodies  >3 publications with ENTPD5 and Blood
 Mammary Gland Antibodies  >2 publications with ENTPD5 and Mammary Gland
 Brain Antibodies  >2 publications with ENTPD5 and Brain
 Lung Antibodies  >2 publications with ENTPD5 and Lung
 Prostate Antibodies  >2 publications with ENTPD5 and Prostate
 Embryonic Tissue Antibodies  >2 publications with ENTPD5 and Embryonic Tissue
 Kidney Antibodies  >2 publications with ENTPD5 and Kidney
 Skin Antibodies  >1 publications with ENTPD5 and Skin
 Muscle Antibodies  >1 publications with ENTPD5 and Muscle
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