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CRIM1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248155

MBS248155 is an antibody targeting CRIM1. Also known as Rabbit Polyclonal to Human CRIM1. Reactive in Human. Host: Rabbit. More details

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Testing Data View PDF
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Product Overview

Product Name
CRIM1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human CRIM1
Product Gene Name
Product Synonym Names
Anti-CRIM1 Antibody (C-Terminus) IHC-plus; CRIM1; CRIM-1; Cysteine-rich motor neuron 1; S52; Human CRIM1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human CRIM1. CRIM1 antibody is human reactive. CRIM1 antibody is predicted to not cross-react with CRIM2.
Preparation and Storage
Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
Molecular Weight
113,738 Da
OMIM
606189
3D Structure
ModBase 3D Structure for Q9NZV1
Target Species
Human
Immunogen Description
A 17 amino acid peptide near the carboxy terminus of human Crim1.
Immunogen Type
Synthetic peptide
Immunogen
CRIM1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human Crim1.
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-CRIM1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-CRIM1 antibody
IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
Usage: CRIM1 antibody can be used for detection of Crim1 by Western blot at 1-2 ug/ml.

Immunohistochemistry (IHC) of anti-CRIM1 antibody

Anti-CRIM1 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-CRIM1 Polyclonal Antibody – Cat# MBS248155

Immunofluorescence (IF) of anti-CRIM1 antibody

Immunofluorescence of CRIM1 in Jurkat cells with CRIM1 antibody at 20 ug/ml.
Rabbit Anti-CRIM1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS248155

Western Blot (WB) of anti-CRIM1 antibody

Western blot analysis of CRIM1 in Jurkat cell lysate with Crim1 antibody at 1 ug/ml.
Rabbit Anti-CRIM1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248155

Other Notes

Small volumes of anti-CRIM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CRIM1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cysteine-rich motor neuron 1 protein
NCBI Official Synonym Full Names
cysteine rich transmembrane BMP regulator 1 (chordin-like)
NCBI Official Symbol
CRIM1
NCBI Official Synonym Symbols
S52; CRIM-1
UniProt Protein Name
Cysteine-rich motor neuron 1 protein
UniProt Synonym Protein Names
Cysteine-rich repeat-containing protein S52Processed cysteine-rich motor neuron 1 protein
UniProt Gene Name
CRIM1
UniProt Synonym Gene Names
S52; CRIM-1
UniProt Entry Name
CRIM1_HUMAN
NCBI Protein Information
cysteine-rich motor neuron 1 protein; cysteine-rich repeat-containing protein S52

NCBI Summary for CRIM1

This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]
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UniProt Comments for CRIM1

CRIM1: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: integral to membrane; plasma membrane

Molecular Function: serine-type endopeptidase inhibitor activity; insulin-like growth factor binding; insulin-like growth factor receptor activity; PDZ domain binding

Biological Process: nervous system development; insulin-like growth factor receptor signaling pathway; regulation of cell growth
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRIM1 antibody

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