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SPC18 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248259

MBS248259 is an antibody targeting SPC18. Also known as Rabbit Polyclonal to Human SPC18 / SEC11A. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SPC18 / SEC11A, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human SPC18 / SEC11A
Product Gene Name
Product Synonym Gene Name
SEC11A
Product Synonym Names
Anti-SPC18 / SEC11A Antibody (aa95-123) IHC-plus; SEC11A; Endopeptidase SP18; SEC11 homolog A; SPase 18 kDa subunit; SEC11-like 1; Sid2895; Signal peptidase 18 kDa; SPC18; SEC11-like 1 (S. cerevisiae); SEC11-like protein 1; SEC11L1; SPCS4A; Human SPC18; SEC11A
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity Purified
Specificity
Human SPC18 / SEC11A
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
18,988 Da
3D Structure
ModBase 3D Structure for P67812
Target Species
Human
Immunogen Description
KLH-conjugated synthetic peptide from internal region of human SC11A.
Immunogen Type
Synthetic peptide
Immunogen
SPC18 / SEC11A antibody was raised against kLH-conjugated synthetic peptide from internal region of human SC11A.
Antigen Modification
aa95-123
Applications Tested/Suitable for anti-SPC18 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-SPC18 antibody
IHC-P (5 ug/ml), WB (1:1000)

Immunohistochemistry (IHC) of anti-SPC18 antibody

Anti-SPC18 / SEC11A antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-SPC18 Polyclonal Antibody – Cat# MBS248259

Western Blot (WB) of anti-SPC18 antibody

SC11A Antibody (Center) Western blot of HepG2 cell line lysates (35 ug/lane). This demonstrates the SC11A antibody detected the SC11A protein (arrow).
Rabbit Anti-SPC18 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248259

Other Notes

Small volumes of anti-SPC18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SPC18. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
signal peptidase complex catalytic subunit SEC11A isoform 2
NCBI Official Synonym Full Names
SEC11 homolog A (S. cerevisiae)
NCBI Official Symbol
SEC11A
NCBI Official Synonym Symbols
SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik
UniProt Protein Name
Signal peptidase complex catalytic subunit SEC11A
UniProt Synonym Protein Names
Endopeptidase SP18; Microsomal signal peptidase 18 kDa subunit; SPase 18 kDa subunit; SEC11 homolog A; SEC11-like protein 1; SPC18
UniProt Gene Name
SEC11A
UniProt Synonym Gene Names
SEC11L1; SPC18; SPCS4A; SPase 18 kDa subunit
UniProt Entry Name
SC11A_HUMAN
NCBI Protein Information
signal peptidase complex catalytic subunit SEC11A; endopeptidase SP18; SEC11-like protein 1; SPase 18 kDa subunit; signal peptidase complex (18kD); microsomal signal peptidase 18 kDa subunit

NCBI Summary for SPC18

This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
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UniProt Comments for SPC18

SEC11A: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Belongs to the peptidase S26B family.

Protein type: EC 3.4.21.89; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 15q25.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: serine-type peptidase activity

Biological Process: SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translation; signal peptide processing; gene expression; proteolysis; regulation of insulin secretion
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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