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POM121 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248270

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
POM121, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human POM121
Product Gene Name
anti-POM121 antibody
Product Synonym Names
Anti-POM121 Antibody (aa1197-1246) IHC-plus; POM121; DKFZP586P2220; KIAA0618; Nucleoporin Nup121; NUP121; p145; POM121 membrane glycoprotein; DKFZP586G1822; POM121A; Human POM121
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
POM121 Antibody detects endogenous levels of total POM121 protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
100,864 Da
OMIM
615753
3D Structure
ModBase 3D Structure for Q96HA1
Target Species
Human
Immunogen Description
Synthetic peptide from human POM121 (aa1197-1246).
Immunogen
POM121 antibody was raised against synthetic peptide from human POM121 (aa1197-1246).
Antigen Modification
aa1197-1246
Applications Tested/Suitable for anti-POM121 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-POM121 antibody
ELISA (1:40000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-POM121 antibody

Anti-POM121 antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-POM121 Polyclonal Antibody – Cat# MBS248270

Western Blot (WB) of anti-POM121 antibody

Western blot of extracts from K562 cells, using POM121 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-POM121 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248270

Other Notes

Small volumes of anti-POM121 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for POM121 purchase

MBS248270 is an antibody targeting POM121. Also known as Rabbit Polyclonal (IgG) to Human POM121. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for POM121. It may not necessarily be applicable to this product.

NCBI GI #
26051278
NCBI GeneID
9883
NCBI Accession #
NP_742017.1
UniProt Primary Accession #
Q96HA1
UniProt Secondary Accession #
O75115; Q96DI0; Q9H9X1; Q9Y2N3; Q9Y4S7; A6NFS9; A8CDT4; A8K933; A8MXF9
UniProt Related Accession #
Q96HA1
GenBank Nucleotide #
NM_172020.4
NCBI Official Full Name
nuclear envelope pore membrane protein POM 121 isoform 2
NCBI Official Synonym Full Names
POM121 transmembrane nucleoporin
NCBI Official Symbol
POM121
NCBI Official Synonym Symbols
P145; POM121A
UniProt Protein Name
Nuclear envelope pore membrane protein POM 121
UniProt Synonym Protein Names
Nuclear envelope pore membrane protein POM 121A; Nucleoporin Nup121; Pore membrane protein of 121 kDa
Protein Family
Nuclear envelope pore membrane protein
UniProt Gene Name
POM121
UniProt Synonym Gene Names
KIAA0618; NUP121; POM121A
UniProt Entry Name
P121A_HUMAN
NCBI Protein Information
nuclear envelope pore membrane protein POM 121; nucleoporin Nup121; POM121 membrane glycoprotein; nuclear pore membrane protein 121 kDa; nuclear envelope pore membrane protein POM 121A

NCBI Summary for POM121

This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]
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UniProt Comments for POM121

POM121: a single-pass membrane protein that is an essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL). Stably associated with the NPC throughout interphase and with the endoplasmic reticulum during metaphase. Contains F-X-F-G repeats. Belongs to the POM121 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Nucleoporin

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: endoplasmic reticulum membrane; nuclear membrane; nuclear envelope; nuclear pore

Biological Process: mRNA transport; viral reproduction; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; pathogenesis; glucose transport; viral infectious cycle; protein transport; hexose transport; carbohydrate metabolic process; gene expression; viral transcription; mitotic cell cycle; transmembrane transport
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Research Articles on POM121

1. Data suggest that the nuclear migration of Pom121 and its subsequent interaction with inner nuclear membrane proteins are required to initiate interphase nuclear pore complex assembly.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-POM121 antibody

 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Export Of Viral Ribonucleoproteins From Nucleus Pathway antibodies  Export Of Viral Ribonucleoproteins From Nucleus Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Glucose Transport Pathway antibodies  Glucose Transport Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram

Diseases associated with anti-POM121 antibody

 Disease Name  Pubmed Publications
 Craniofacial Abnormalities Antibodies  >1 publications with POM121 and Craniofacial Abnormalities
 Heart Defects, Congenital Antibodies  >1 publications with POM121 and Heart Defects, Congenital
 Lymphoma Antibodies  >1 publications with POM121 and Lymphoma
 Chromosome Aberrations Antibodies  >1 publications with POM121 and Chromosome Aberrations
 Necrosis Antibodies  >1 publications with POM121 and Necrosis
 Immune System Diseases Antibodies  >1 publications with POM121 and Immune System Diseases

Organs/Tissues associated with anti-POM121 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with POM121 and Liver
 Kidney Antibodies  >2 publications with POM121 and Kidney
 Thymus Antibodies  >2 publications with POM121 and Thymus
 Vascular Antibodies  >1 publications with POM121 and Vascular
 Ovary Antibodies  >1 publications with POM121 and Ovary
 Spleen Antibodies  >1 publications with POM121 and Spleen
 Muscle Antibodies  >1 publications with POM121 and Muscle
 Prostate Antibodies  >1 publications with POM121 and Prostate
 Intestine Antibodies  >1 publications with POM121 and Intestine
 Brain Antibodies  >1 publications with POM121 and Brain
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