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FCER1G Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248276

MBS248276 is an antibody targeting FCER1G. Also known as Rabbit Polyclonal to Human FCER1G. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
FCER1G, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human FCER1G
Product Gene Name
anti-FCER1G antibody
Product Synonym Names
Anti-FCER1G Antibody (aa60-86) IHC-plus; FCER1G; FceRI gamma; IgE Fc receptor subunit gamma; FcRgamma; Gamma polypeptide; Fc receptor gamma-chain; Fc-epsilon RI-gamma; FCRG; Human FCER1G
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity Purified
Specificity
Human FCER1G
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
9,667 Da
OMIM
147139
3D Structure
ModBase 3D Structure for P30273
Target Species
Human
Immunogen Description
KLH-conjugated synthetic peptide from C-terminal region of human FCER1G.
Immunogen Type
Synthetic peptide
Immunogen
FCER1G antibody was raised against kLH-conjugated synthetic peptide from C-terminal region of human FCER1G.
Antigen Modification
aa60-86
Applications Tested/Suitable for anti-FCER1G antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-FCER1G antibody
IHC-P (1:75), WB (1:1000)

Immunohistochemistry (IHC) of anti-FCER1G antibody

Anti-FCER1G antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.
Rabbit Anti-FCER1G Polyclonal Antibody – Cat# MBS248276

Western Blot (WB) of anti-FCER1G antibody

FCER1G Antibody (C-term) Western blot of human spleen tissue lysates (35 ug/lane). This demonstrates the FCER1G antibody detected the FCER1G protein (arrow).
Rabbit Anti-FCER1G Polyclonal Antibody, Western Blot (WB) – Cat# MBS248276

Other Notes

Small volumes of anti-FCER1G antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FCER1G. It may not necessarily be applicable to this product.

NCBI GI #
4758344
NCBI GeneID
2207
NCBI Accession #
NP_004097.1
UniProt Primary Accession #
P30273
UniProt Secondary Accession #
Q5VTW4
UniProt Related Accession #
P30273
GenBank Nucleotide #
NM_004106.1
NCBI Official Full Name
high affinity immunoglobulin epsilon receptor subunit gamma
NCBI Official Synonym Full Names
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
NCBI Official Symbol
FCER1G
NCBI Official Synonym Symbols
FCRG
UniProt Protein Name
High affinity immunoglobulin epsilon receptor subunit gamma
UniProt Synonym Protein Names
Fc receptor gamma-chain; FcRgamma; Fc-epsilon RI-gamma; IgE Fc receptor subunit gamma; FceRI gamma
Protein Family
High affinity immunoglobulin epsilon receptor
UniProt Gene Name
FCER1G
UniProt Synonym Gene Names
FcRgamma; FceRI gamma
UniProt Entry Name
FCERG_HUMAN
NCBI Protein Information
high affinity immunoglobulin epsilon receptor subunit gamma; fcRgamma; fceRI gamma; fc-epsilon RI-gamma; Fc receptor gamma-chain; immunoglobulin E receptor, high affinity, gamma chain

NCBI Summary for FCER1G

The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]

UniProt Comments for FCER1G

FCER1G: Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. Also involved in collagen-mediated platelet activation and in neutrophil activation mediated by integrin. Belongs to the CD3Z/FCER1G family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: cell surface; integral to plasma membrane; Fc-epsilon receptor I complex; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; IgG binding; IgE binding; IgE receptor activity

Biological Process: integrin-mediated signaling pathway; platelet activation; neutrophil chemotaxis; positive regulation of type I hypersensitivity; antigen processing and presentation of exogenous peptide antigen via MHC class II; positive regulation of interleukin-6 production; positive regulation of type III hypersensitivity; positive regulation of mast cell degranulation; positive regulation of tumor necrosis factor production; mast cell activation; positive regulation of interleukin-10 production; neutrophil activation during immune response; serotonin secretion by platelet; negative regulation of mast cell apoptosis; positive regulation of phagocytosis; positive regulation of type IIa hypersensitivity; defense response to bacterium; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; Fc receptor mediated stimulatory signaling pathway; immunoglobulin mediated immune response; positive regulation of mast cell cytokine production; phagocytosis, engulfment; blood coagulation; leukocyte migration
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Research Articles on FCER1G

1. Studies indicate that in response to stimulation with antigen, PHB1 translocated to plasma membrane lipid rafts to form a ternary complex with the high-affinity IgE receptor FcepsilonRIgamma and the nonreceptor tyrosine kinase Syk.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FCER1G antibody

 Reference Product  PubMed Publications
 FCER1A antibody  >5 publications with FCER1G and FCER1A

Pathways associated with anti-FCER1G antibody

 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon Receptor (FCERI) Signaling Pathway antibodies  Fc Epsilon Receptor (FCERI) Signaling Pathway Diagram
 Fc-epsilon Receptor I Signaling In Mast Cells Pathway antibodies  Fc-epsilon Receptor I Signaling In Mast Cells Pathway Diagram
 GPVI-mediated Activation Cascade Pathway antibodies  GPVI-mediated Activation Cascade Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Diseases associated with anti-FCER1G antibody

 Disease Name  Pubmed Publications
 Genetic Predisposition to Disease Antibodies  >5 publications with FCER1G and Genetic Predisposition to Disease
 Inflammation Antibodies  >3 publications with FCER1G and Inflammation
 Respiratory Hypersensitivity Antibodies  >2 publications with FCER1G and Respiratory Hypersensitivity
 Asthma Antibodies  >2 publications with FCER1G and Asthma
 Lung Diseases Antibodies  >2 publications with FCER1G and Lung Diseases
 Necrosis Antibodies  >2 publications with FCER1G and Necrosis
 Weight Gain Antibodies  >1 publications with FCER1G and Weight Gain
 Disease Models, Animal Antibodies  >1 publications with FCER1G and Disease Models, Animal

Organs/Tissues associated with anti-FCER1G antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with FCER1G and Blood
 Brain Antibodies  >3 publications with FCER1G and Brain
 Lung Antibodies  >1 publications with FCER1G and Lung
 Connective Tissue Antibodies  >1 publications with FCER1G and Connective Tissue
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