GNAQ Antibody – Rabbit Polyclonal

This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]

G-alpha(q): a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein type: G protein; G protein, heterotrimeric alpha G(q); G protein, heterotrimeric

Chromosomal Location of Human Ortholog: 9q21

Cellular Component: nuclear membrane; lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex

Molecular Function: GTPase activity; signal transducer activity; protein binding; GTP binding; type 2A serotonin receptor binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activator activity

Biological Process: regulation of action potential; platelet activation; protein stabilization; maternal behavior; metabolic process; glutamate signaling pathway; heart development; pigmentation during development; G-protein signaling, adenylate cyclase activating pathway; post-embryonic development; regulation of melanocyte differentiation; phospholipase C activation; forebrain neuron development; negative regulation of protein kinase activity; embryonic digit morphogenesis; dopamine receptor, phospholipase C activating pathway; blood coagulation; skeletal development; positive regulation of GTPase activity; neuron remodeling

Disease: Sturge-weber Syndrome; Capillary Malformations, Congenital