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DOK4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248297

MBS248297 is an antibody targeting DOK4. Also known as Rabbit Polyclonal (IgG) to Human DOK4. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
DOK4, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human DOK4
Product Gene Name
anti-DOK4 antibody
Product Synonym Names
Anti-DOK4 Antibody (aa11-60) IHC-plus; DOK4; Docking protein 4; Insulin receptor substrate 5; IRS5; IRS-5; Human DOK4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
DOK4 Antibody detects endogenous levels of total DOK4 protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
37,028 Da
OMIM
608333
3D Structure
ModBase 3D Structure for Q8TEW6
Target Species
Human
Immunogen Description
Synthetic peptide from human DOK4 (aa11-60).
Immunogen
DOK4 antibody was raised against synthetic peptide from human DOK4 (aa11-60).
Antigen Modification
aa11-60
Applications Tested/Suitable for anti-DOK4 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-DOK4 antibody
ELISA (1:20000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-DOK4 antibody

Anti-DOK4 antibody IHC staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-DOK4 Polyclonal Antibody – Cat# MBS248297

Western Blot (WB) of anti-DOK4 antibody

Western blot of extracts from 293/mouse lung cells, using DOK4 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-DOK4 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248297

Other Notes

Small volumes of anti-DOK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DOK4. It may not necessarily be applicable to this product.

NCBI GI #
20070302
NCBI GeneID
55715
NCBI Accession #
NP_060580.2
UniProt Primary Accession #
Q8TEW6
UniProt Secondary Accession #
O75209; Q9BTP2; Q9NVV3
UniProt Related Accession #
Q8TEW6
GenBank Nucleotide #
NM_018110.3
NCBI Official Full Name
docking protein 4
NCBI Official Synonym Full Names
docking protein 4
NCBI Official Symbol
DOK4
UniProt Protein Name
Docking protein 4
UniProt Synonym Protein Names
Downstream of tyrosine kinase 4; Insulin receptor substrate 5; IRS-5; IRS5
Protein Family
Docking protein
UniProt Gene Name
DOK4
UniProt Synonym Gene Names
IRS-5; IRS5
UniProt Entry Name
DOK4_HUMAN
NCBI Protein Information
docking protein 4; IRS5; IRS-5; insulin receptor substrate 5; downstream of tyrosine kinase 4

UniProt Comments for DOK4

DOK4: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in Ret-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of Ret in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. Interacts with Ret and TIE2. Interaction with Ret is mediated through the PTB domain and requires phosphorylation of Ret Y1062.

Protein type: Adaptor/scaffold; Cell development/differentiation

Chromosomal Location of Human Ortholog: 16q21

Molecular Function: protein binding; receptor signaling protein activity; insulin receptor binding

Biological Process: nervous system development; MAPKKK cascade; transmembrane receptor protein tyrosine kinase signaling pathway
Show more

Research Articles on DOK4

1. the current study have explored in more detail the structure and function of the Dok-4 PTB domain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DOK4 antibody

 Reference Product  PubMed Publications
 RET antibody  >5 publications with DOK4 and RET
 SRC antibody  >3 publications with DOK4 and SRC
 FYN antibody  >2 publications with DOK4 and FYN
 GDNF antibody  >2 publications with DOK4 and GDNF
 CRK antibody  >1 publications with DOK4 and CRK

Pathways associated with anti-DOK4 antibody

 Products by Pathway  Pathway Diagram
 Signaling Events Regulated By Ret Tyrosine Kinase Pathway antibodies  Signaling Events Regulated By Ret Tyrosine Kinase Pathway Diagram

Diseases associated with anti-DOK4 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >3 publications with DOK4 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >2 publications with DOK4 and Carcinoma, Squamous Cell
 Nervous System Diseases Antibodies  >1 publications with DOK4 and Nervous System Diseases
 Kidney Diseases Antibodies  >1 publications with DOK4 and Kidney Diseases
 Lymphoma Antibodies  >1 publications with DOK4 and Lymphoma
 Poisoning Antibodies  >1 publications with DOK4 and Poisoning
 Inflammation Antibodies  >1 publications with DOK4 and Inflammation
 Breast Neoplasms Antibodies  >1 publications with DOK4 and Breast Neoplasms
 Necrosis Antibodies  >1 publications with DOK4 and Necrosis

Organs/Tissues associated with anti-DOK4 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >3 publications with DOK4 and Muscle
 Lung Antibodies  >3 publications with DOK4 and Lung
 Kidney Antibodies  >3 publications with DOK4 and Kidney
 Vascular Antibodies  >2 publications with DOK4 and Vascular
 Connective Tissue Antibodies  >1 publications with DOK4 and Connective Tissue
 Liver Antibodies  >1 publications with DOK4 and Liver
 Skin Antibodies  >1 publications with DOK4 and Skin
 Embryonic Tissue Antibodies  >1 publications with DOK4 and Embryonic Tissue
 Heart Antibodies  >1 publications with DOK4 and Heart
 Intestine Antibodies  >1 publications with DOK4 and Intestine
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