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ANXA8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248309

Annexin VIII (ANXA8) belongs to the family of Ca (2+) dependent phospholipid binding proteins (annexins), and has a high 56% identity to annexin V (vascular anticoagulant-alpha). It was initially isolated as 2.2 kb vascular anticoagulant-beta transcript from… More details

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Product Overview

Product Name
ANXA8 / Annexin A8, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human ANXA8 / Annexin A8
Product Gene Name
Product Synonym Names
Anti-ANXA8 / Annexin A8 Antibody IHC-plus; ANXA8; Annexin A8; Annexin-8; ANX8; Vascular anticoagulant-beta; Annexin VIII; VAC-beta; Human ANXA8; Annexin A8
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, pH 7.2, 30% glycerol, 0.5% BSA, 0.01% Thimerosal.
Purity/Purification
Protein A Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
The antibody detects 36 kD annexin VIII of human origin. The ~28-30 kD cleavage fragments can also be detected in Jurkat cell lysate. Blocking peptide is available separately.
Preparation and Storage
Short term +4 degree C (no longer than one week); Long term -20 degree C; Aliquot to avoid freeze/thaw cycles.
Molecular Weight
16,070 Da
OMIM
602396
3D Structure
ModBase 3D Structure for P13928
Target Species
Human
Immunogen Description
Synthetic peptide surrounding amino acid 316 of human Annexin VIII.
Immunogen Type
Synthetic peptide
Immunogen
ANXA8 / Annexin A8 antibody was raised against synthetic peptide surrounding amino acid 316 of human Annexin VIII.
Applications Tested/Suitable for anti-ANXA8 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-ANXA8 antibody
IHC-P (5 ug/ml), WB (0.5 - 4 ug/ml)

Immunohistochemistry (IHC) of anti-ANXA8 antibody

Anti-ANXA8 / Annexin A8 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-ANXA8 Polyclonal Antibody – Cat# MBS248309

Other Notes

Small volumes of anti-ANXA8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANXA8 purchase

MBS248309 is an antibody targeting ANXA8. Also known as Rabbit Polyclonal (IgG) to Human ANXA8 / Annexin A8. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ANXA8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
annexin A8 isoform 2
NCBI Official Synonym Full Names
annexin A8
NCBI Official Symbol
ANXA8
NCBI Official Synonym Symbols
ANX8
UniProt Protein Name
Annexin A8
UniProt Synonym Protein Names
Annexin VIII; Annexin-8; Vascular anticoagulant-beta; VAC-beta
Protein Family
UniProt Gene Name
ANXA8
UniProt Synonym Gene Names
ANX8; VAC-beta
UniProt Entry Name
ANXA8_HUMAN
NCBI Protein Information
annexin A8; VAC-beta; annexin-8; annexin VIII; vascular anticoagulant-beta

NCBI Summary for ANXA8

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]
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UniProt Comments for ANXA8

ANXA8: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Belongs to the annexin family.

Chromosomal Location of Human Ortholog: 10q11.22

Cellular Component: late endosome membrane; plasma membrane; cytosol

Molecular Function: actin filament binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; calcium-dependent phospholipid binding; calcium ion binding; phosphatidylinositol-3,4-bisphosphate binding

Biological Process: endosome organization and biogenesis; blood coagulation; endosome transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ANXA8 antibody

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