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PSPLA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248337

MBS248337 is an antibody targeting PSPLA1. Also known as Rabbit Polyclonal (IgG) to Human PSPLA1 / PLA1A. Reactive in Human, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PSPLA1 / PLA1A, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human PSPLA1 / PLA1A
Product Gene Name
anti-PSPLA1 antibody
Product Synonym Gene Name
PLA1A
Product Synonym Names
Anti-PSPLA1 / PLA1A Antibody (C-Terminus) IHC-plus; PLA1A; NMD; Phospholipase a1; PS-PLA1; Phospholipase A1 member A; PSPLA1; Human PSPLA1; PLA1A
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human PLA1A. At least three isoforms of PLA1A are known to exist; this antibody will detect all three isoforms.
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
Molecular Weight
31,285 Da
OMIM
607460
3D Structure
ModBase 3D Structure for Q53H76
Target Species
Human
Immunogen Description
A 17 amino acid peptide near the carboxy terminus of human PLA1A.
Immunogen Type
Synthetic peptide
Immunogen
PSPLA1 / PLA1A antibody was raised against a 17 amino acid peptide near the carboxy terminus of human PLA1A.
Antigen Modification
C-Terminus

Product Categories/Family for anti-PSPLA1 antibody

Family: Phospholipase
Applications Tested/Suitable for anti-PSPLA1 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-PSPLA1 antibody
ELISA, IF (20 ug/ml), IHC-P (10 ug/ml), WB (1 - 2 ug/ml)
Usage: PLA1A antibody can be used for detection of PLA1A by Western blot at 1-2 ug/mL.

Immunohistochemistry (IHC) of anti-PSPLA1 antibody

Anti-PSPLA1 / PLA1A antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-PSPLA1 Polyclonal Antibody – Cat# MBS248337

Immunohistochemistry (IHC) of anti-PSPLA1 antibody

Anti-PSPLA1 / PLA1A antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-PSPLA1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS248337

Immunofluorescence (IF) of anti-PSPLA1 antibody

Immunofluorescence of PLA1A in human kidney tissue with PLA1A antibody at 20 ug/ml.
Rabbit Anti-PSPLA1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS248337

Immunofluorescence (IF) of anti-PSPLA1 antibody

Immunofluorescence of PLA1A in human kidney tissue with PLA1A antibody at 20 µg/mL.
Rabbit Anti-PSPLA1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS248337

Western Blot (WB) of anti-PSPLA1 antibody

Western blot analysis of PLA1A in human kidney tissue lysate with PLA1A antibody at (A) 1 and (B) 2 ug/ml.
Rabbit Anti-PSPLA1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248337

Other Notes

Small volumes of anti-PSPLA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PSPLA1. It may not necessarily be applicable to this product.

NCBI GI #
7706661
NCBI GeneID
51365
NCBI Accession #
NP_056984.1
UniProt Primary Accession #
Q53H76
UniProt Secondary Accession #
O95991; Q86WX6; Q9UPD2; B2R8V2; B4DXA2
UniProt Related Accession #
Q53H76
GenBank Nucleotide #
NM_015900.3
NCBI Official Full Name
phospholipase A1 member A isoform 1
NCBI Official Synonym Full Names
phospholipase A1 member A
NCBI Official Symbol
PLA1A
NCBI Official Synonym Symbols
PSPLA1; PS-PLA1
UniProt Protein Name
Phospholipase A1 member A
UniProt Synonym Protein Names
Phosphatidylserine-specific phospholipase A1; PS-PLA1
UniProt Gene Name
PLA1A
UniProt Synonym Gene Names
NMD; PSPLA1; PS-PLA1
UniProt Entry Name
PLA1A_HUMAN
NCBI Protein Information
phospholipase A1 member A; phosphatidylserine-specific phospholipase A1alpha

NCBI Summary for PSPLA1

The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
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UniProt Comments for PSPLA1

PLA1A: Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. Belongs to the AB hydrolase superfamily. Lipase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Phospholipase; EC 3.1.1.-

Chromosomal Location of Human Ortholog: 3q13.13-q13.2

Cellular Component: acrosomal membrane

Molecular Function: phospholipase A1 activity

Biological Process: phosphatidylserine metabolic process; lipid metabolic process; lipid catabolic process
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Research Articles on PSPLA1

1. PLA1A2 polymorphism is associated with mortality in participants whose hemoglobin A1c ranges from 5.5% to 6.5%.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PSPLA1 antibody

 Products by Pathway  Pathway Diagram
 Ras Signaling Pathway antibodies  Ras Signaling Pathway Diagram

Diseases associated with anti-PSPLA1 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >2 publications with PSPLA1 and Necrosis
 Hepatitis Antibodies  >1 publications with PSPLA1 and Hepatitis
 Fibrosis Antibodies  >1 publications with PSPLA1 and Fibrosis
 Fatty Liver Antibodies  >1 publications with PSPLA1 and Fatty Liver
 Inflammation Antibodies  >1 publications with PSPLA1 and Inflammation

Organs/Tissues associated with anti-PSPLA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with PSPLA1 and Blood
 Heart Antibodies  >1 publications with PSPLA1 and Heart
 Prostate Antibodies  >1 publications with PSPLA1 and Prostate
 Liver Antibodies  >1 publications with PSPLA1 and Liver
 Skin Antibodies  >1 publications with PSPLA1 and Skin
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