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SLC6A12 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248410

MBS248410 is an antibody targeting SLC6A12. Also known as Goat Polyclonal to Human SLC6A12 / BGT-1. Reactive in Chimpanzee, Gorilla, Human. Host: Goat. More details

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Testing Data View PDF
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Product Overview

Product Name
SLC6A12 / BGT-1, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human SLC6A12 / BGT-1
Product Gene Name
anti-SLC6A12 antibody
Product Synonym Gene Name
BGT-1
Product Synonym Names
Anti-SLC6A12 / BGT-1 Antibody (C-Terminus) IHC-plus; SLC6A12; BGT; BGT-1; BGT1; Gat2 mouse; Betaine transporter; GAT2; Human SLC6A12; BGT-1
Clonality
Polyclonal
Host
Goat
Species Reactivity
Chimpanzee, Gorilla, Human
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human SLC6A12 / BGT-1. Reported variants represent identical protein: NP_001193860.1, NP_003035.3, NP_001116319.1, NP_001116320.1.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
69,368 Da
OMIM
603080
3D Structure
ModBase 3D Structure for P48065
Target Species
Human
Immunogen Description
Synthetic peptide CLDGSAGRNFGPSPT from the C-terminus of human SLC6A12 / BGT-1 (NP_003035.3). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Orangutan (87%).
Immunogen Type
Synthetic peptide
Immunogen
SLC6A12 / BGT-1 antibody was raised against synthetic peptide CLDGSAGRNFGPSPT from the C-terminus of human SLC6A12 / BGT-1 (NP_003035.3). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Orangutan (87%).
Antigen Modification
C-Terminus

Product Categories/Family for anti-SLC6A12 antibody

Family: Transporter; Subfamily: Neurotransmitter:sodium symporter
Applications Tested/Suitable for anti-SLC6A12 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-SLC6A12 antibody
ELISA (1:128000), IHC-P (10 ug/ml), WB (1 - 3 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:128000. Western blot: Approx 70kD band observed in Human Brain lysates from several regions (calculated MW of 69.4kD according to NP_003035.3). Recommended concentration: 1-3 ug/ml. An additional ban...

Immunohistochemistry (IHC) of anti-SLC6A12 antibody

Anti-SLC6A12 / BGT-1 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Goat Anti-SLC6A12 Polyclonal Antibody – Cat# MBS248410

Western Blot (WB) of anti-SLC6A12 antibody

SLC6A12 antibody (1 ug/ml) staining of Human Olfactory bulb lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-SLC6A12 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248410

Other Notes

Small volumes of anti-SLC6A12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC6A12. It may not necessarily be applicable to this product.

NCBI GI #
171184404
NCBI GeneID
6539
NCBI Accession #
NP_003035.3
UniProt Primary Accession #
P48065
UniProt Secondary Accession #
A0AV52; B2R992; D3DUN8
UniProt Related Accession #
P48065
GenBank Nucleotide #
NM_003044.4
NCBI Official Full Name
sodium- and chloride-dependent betaine transporter
NCBI Official Synonym Full Names
solute carrier family 6 (neurotransmitter transporter), member 12
NCBI Official Symbol
SLC6A12
NCBI Official Synonym Symbols
BGT1; GAT2; BGT-1
UniProt Protein Name
Sodium- and chloride-dependent betaine transporter
UniProt Synonym Protein Names
BGT-1; Na(+)/Cl(-) betaine/GABA transporter; Solute carrier family 6 member 12
UniProt Gene Name
SLC6A12
UniProt Entry Name
S6A12_HUMAN
NCBI Protein Information
sodium- and chloride-dependent betaine transporter; betaine/GABA transporter-1; gamma-aminobutyric acid transporter; Na(+)/Cl(-) betaine/GABA transporter; solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

UniProt Comments for SLC6A12

SLC6A12: Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: gamma-aminobutyric acid:sodium symporter activity; neurotransmitter:sodium symporter activity

Biological Process: response to organic substance; synaptic transmission; cellular water homeostasis; transport; amino acid transport; neurotransmitter secretion; ion transport; transmembrane transport; gamma-aminobutyric acid transport
Show more

Research Articles on SLC6A12

1. T40 may be important for the trafficking and insertion of BGT1 in the plasma membrane

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC6A12 antibody

 Reference Product  PubMed Publications
 SLC5A3 antibody  >2 publications with SLC6A12 and SLC5A3

Pathways associated with anti-SLC6A12 antibody

 Products by Pathway  Pathway Diagram
 Amino Acid Transport Across The Plasma Membrane Pathway antibodies  Amino Acid Transport Across The Plasma Membrane Pathway Diagram
 Creatine Metabolism Pathway antibodies  Creatine Metabolism Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Na+/Cl- Dependent Neurotransmitter Transporters Pathway antibodies  Na+/Cl- Dependent Neurotransmitter Transporters Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 Reuptake Of GABA Pathway antibodies  Reuptake Of GABA Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram

Diseases associated with anti-SLC6A12 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with SLC6A12 and Nervous System Diseases
 Seizures Antibodies  >5 publications with SLC6A12 and Seizures
 Brain Diseases Antibodies  >3 publications with SLC6A12 and Brain Diseases
 Neurobehavioral Manifestations Antibodies  >2 publications with SLC6A12 and Neurobehavioral Manifestations
 Cell Transformation, Neoplastic Antibodies  >1 publications with SLC6A12 and Cell Transformation, Neoplastic
 Precancerous Conditions Antibodies  >1 publications with SLC6A12 and Precancerous Conditions
 Learning Disorders Antibodies  >1 publications with SLC6A12 and Learning Disorders
 Memory Disorders Antibodies  >1 publications with SLC6A12 and Memory Disorders
 Lung Diseases Antibodies  >1 publications with SLC6A12 and Lung Diseases
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with SLC6A12 and Drug-Related Side Effects and Adverse Reactions

Organs/Tissues associated with anti-SLC6A12 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with SLC6A12 and Brain
 Kidney Antibodies  >12 publications with SLC6A12 and Kidney
 Liver Antibodies  >6 publications with SLC6A12 and Liver
 Eye Antibodies  >2 publications with SLC6A12 and Eye
 Intestine Antibodies  >1 publications with SLC6A12 and Intestine
 Lung Antibodies  >1 publications with SLC6A12 and Lung
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