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Chordin (CHRD) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248426

MBS248426 is an antibody targeting CHRD. Also known as Rabbit Polyclonal to Human Chordin. Reactive in Human. Host: Rabbit. More details

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Sample Manual Insert View PDF
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Product Overview

Product Name
Chordin (CHRD), Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human Chordin
Product Gene Name
anti-CHRD antibody
Product Synonym Names
Anti-Chordin Antibody (C-Terminus) IHC-plus; CHRD; Chordin; Human Chordin
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS with 0.09% (w/v) sodium azide
Purity/Purification
Immunoaffinity Purified
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
97,731 Da
OMIM
603475
Target Species
Human
Immunogen Description
KLH conjugated synthetic peptide selected from the C-terminal region of human CHRD.
Immunogen Type
Synthetic peptide
Immunogen
Chordin antibody was raised against kLH conjugated synthetic peptide selected from the C-terminal region of human CHRD.
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-CHRD antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-CHRD antibody
IHC-P (10 ug/ml), WB (1:1000)

Immunohistochemistry (IHC) of anti-CHRD antibody

Anti-Chordin antibody IHC staining of human pancreatic duct. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-CHRD Polyclonal Antibody – Cat# MBS248426

Immunohistochemistry (IHC) of anti-CHRD antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with CHRD antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Rabbit Anti-CHRD Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS248426

Western Blot (WB) of anti-CHRD antibody

Western blot of anti-CHRD Antibody (C-term) in HepG2 cell line lysates (35 ug/lane). CHRD(arrow) was detected using the purified Pab (1:60 dilution).
Rabbit Anti-CHRD Polyclonal Antibody, Western Blot (WB) – Cat# MBS248426

Other Notes

Small volumes of anti-CHRD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CHRD. It may not necessarily be applicable to this product.

NCBI GI #
3822218
NCBI GeneID
8646
NCBI Accession #
AAC69835.1
UniProt Secondary Accession #
O95254; Q2M1I8; Q6UW83; Q9H2D3; Q9H2W8; Q9H2W9; Q9P0Z2; Q9P0Z3; Q9P0Z4; Q9P0Z5
UniProt Related Accession #
Q9H2X0
NCBI Official Full Name
chordin, partial
NCBI Official Synonym Full Names
chordin
NCBI Official Symbol
CHRD
UniProt Protein Name
Chordin
Protein Family
Chordin
UniProt Gene Name
CHRD
UniProt Entry Name
CHRD_HUMAN
NCBI Protein Information
chordin

NCBI Summary for CHRD

This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jul 2008]
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UniProt Comments for CHRD

CHRD: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. Belongs to the chordin family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: extracellular space

Molecular Function: syndecan binding; heparin binding; protein binding; cytokine binding

Biological Process: BMP signaling pathway in spinal cord dorsal-ventral patterning; osteoblast differentiation; floor plate development; positive regulation of cell adhesion; mesoderm formation; forebrain development; positive regulation of mesenchymal cell proliferation; negative regulation of osteoblast differentiation; gastrulation with mouth forming second; negative regulation of cell migration; skeletal development; negative regulation of BMP signaling pathway
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Research Articles on CHRD

1. chordin silencing increased osteogenic differentiation without supplemented BMP-2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CHRD antibody

 Products by Pathway  Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram

Diseases associated with anti-CHRD antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >5 publications with CHRD and Heart Diseases
 Fibrosis Antibodies  >2 publications with CHRD and Fibrosis
 Hypertrophy Antibodies  >2 publications with CHRD and Hypertrophy
 Inflammation Antibodies  >1 publications with CHRD and Inflammation
 Neural Tube Defects Antibodies  >1 publications with CHRD and Neural Tube Defects
 Disease Models, Animal Antibodies  >1 publications with CHRD and Disease Models, Animal
 Necrosis Antibodies  >1 publications with CHRD and Necrosis

Organs/Tissues associated with anti-CHRD antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >7 publications with CHRD and Embryonic Tissue
 Brain Antibodies  >4 publications with CHRD and Brain
 Muscle Antibodies  >3 publications with CHRD and Muscle
 Connective Tissue Antibodies  >2 publications with CHRD and Connective Tissue
 Lung Antibodies  >2 publications with CHRD and Lung
 Liver Antibodies  >2 publications with CHRD and Liver
 Kidney Antibodies  >2 publications with CHRD and Kidney
 Ovary Antibodies  >2 publications with CHRD and Ovary
 Adipose Tissue Antibodies  >1 publications with CHRD and Adipose Tissue
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