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VPS13B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248443

MBS248443 is an antibody targeting VPS13B. Also known as Rabbit Polyclonal to Human VPS13B. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
VPS13B, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human VPS13B
Product Gene Name
Product Synonym Names
Anti-VPS13B Antibody (N-Terminus) IHC-plus; VPS13B; Cohen syndrome 1; Cohen syndrome protein 1; KIAA0532; CHS1; COH1; Human VPS13B
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human VPS13B. At least five alternatively spliced transcript variants have been observed. COH1 detects two isoforms.
Preparation and Storage
Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
Molecular Weight
448,536 Da
OMIM
phenotype 607817
3D Structure
ModBase 3D Structure for Q7Z7G8
Target Species
Human
Immunogen Description
A 17 amino acid peptide near the amino terminus of human COH1.
Immunogen Type
Synthetic peptide
Immunogen
VPS13B antibody was raised against a 17 amino acid peptide near the amino terminus of human COH1.
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-VPS13B antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-VPS13B antibody
IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
Usage: COH1 antibody can be used for detection of COH1 by Western blot at 1-2 ug/ml.

Immunohistochemistry (IHC) of anti-VPS13B antibody

Anti-VPS13B antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-VPS13B Polyclonal Antibody – Cat# MBS248443

Immunofluorescence (IF) of anti-VPS13B antibody

Immunofluorescence of COH1 in human brain tissue with COH1 antibody at 20 ug/ml.
Rabbit Anti-VPS13B Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS248443

Western Blot (WB) of anti-VPS13B antibody

Western blot analysis of COH1 in SK-N-SH cell lysate with COH1 antibody at (A) 1 and (B) 2 ug/ml.
Rabbit Anti-VPS13B Polyclonal Antibody, Western Blot (WB) – Cat# MBS248443

Other Notes

Small volumes of anti-VPS13B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VPS13B. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
vacuolar protein sorting-associated protein 13B isoform 5
NCBI Official Synonym Full Names
vacuolar protein sorting 13 homolog B (yeast)
NCBI Official Symbol
VPS13B
NCBI Official Synonym Symbols
CHS1; COH1
UniProt Protein Name
Vacuolar protein sorting-associated protein 13B
UniProt Synonym Protein Names
Cohen syndrome protein 1
UniProt Gene Name
VPS13B
UniProt Synonym Gene Names
CHS1; COH1; KIAA0532
UniProt Entry Name
VP13B_HUMAN
NCBI Protein Information
vacuolar protein sorting-associated protein 13B

NCBI Summary for VPS13B

This gene encodes a potential transmembrane protein that may function in vesicle-mediated transport and sorting of proteins within the cell. This protein may play a role in the development and the function of the eye, hematological system, and central nervous system. Mutations in this gene have been associated with Cohen syndrome. Multiple splice variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for VPS13B

VPS13B: May be involved in protein sorting in post Golgi membrane traffic. Defects in VPS13B are a cause of Cohen syndrome (COH1). COH1 is a rare autosomal recessive disorder characterized by obesity, hypotonia, intellectual deficit, characteristic craniofacial dysmorphism and abnormalities of the hands and feet. Characteristic facial features include high-arched or wave-shaped eyelids, a short philtrum, thick hair and low hairline. Belongs to the VPS13 family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q22.2

Biological Process: protein transport

Disease: Cohen Syndrome
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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