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DNAJC5 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248450

MBS248450 is an antibody targeting DNAJC5. Also known as Goat Polyclonal to Human DNAJC5 / CSP. Reactive in Gibbon, Bovine, Chimpanzee, Chicken, Dog, Guinea pig, Gorilla, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat. Host: Goat. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
DNAJC5 / CSP, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human DNAJC5 / CSP
Product Gene Name
anti-DNAJC5 antibody
Product Synonym Gene Name
CSP
Product Synonym Names
Anti-DNAJC5 / CSP Antibody (aa177-191) IHC-plus; DNAJC5; CLN4; CLN4B; CSP; Cysteine string protein alpha; DNAJC5A; Cysteine string protein; Human DNAJC5; CSP
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Bovine, Chimpanzee, Chicken, Dog, Guinea pig, Gorilla, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human DNAJC5 / CSP
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
18,801 Da
OMIM
phenotype 611203
3D Structure
ModBase 3D Structure for Q9H3Z4
Target Species
Human
Immunogen Description
Synthetic peptide C-SATETTQLTADSHPS from the C-terminus of human DNAJC5 / CSP (NP_058055.1).
Immunogen Type
Synthetic peptide
Immunogen
DNAJC5 / CSP antibody was raised against synthetic peptide C-SATETTQLTADSHPS from the C-terminus of human DNAJC5 / CSP (NP_058055.1). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Ferret, Panda, Dog, Cat, Bovine, Horse, Rabbit, Guinea pig, Turkey, Zebra finch, Chicken, Platypus, Lizard (100%); Xenopus (87%); Salmon, Stickleback, Medaka, Pufferfish, Zebrafish (80%).
Antigen Modification
aa177-191
Applications Tested/Suitable for anti-DNAJC5 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-DNAJC5 antibody
ELISA (1:64000), IHC-P (5 ug/ml), WB (0.5 - 1.5 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:64000. Western blot: Approx 20kD band observed in Human Brain (Cerebellum) lysates (calculated MW of 22.1kD according to NP_058055.1). Recommended concentration: 0.5-1.5 ug/ml.

Immunohistochemistry (IHC) of anti-DNAJC5 antibody

Anti-DNAJC5 / CSP antibody IHC staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Goat Anti-DNAJC5 Polyclonal Antibody – Cat# MBS248450

Western Blot (WB) of anti-DNAJC5 antibody

DNAJC5 antibody (0.5 ug/ml) staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-DNAJC5 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248450

Other Notes

Small volumes of anti-DNAJC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DNAJC5. It may not necessarily be applicable to this product.

NCBI GI #
45504382
NCBI GeneID
80331
NCBI Accession #
NP_079495.1
UniProt Primary Accession #
Q9H3Z4
UniProt Secondary Accession #
Q9H3Z5; Q9H7H2; A8K0M0; B3KY68; E1P5G8
UniProt Related Accession #
Q9H3Z4
GenBank Nucleotide #
NM_025219.2
NCBI Official Full Name
dnaJ homolog subfamily C member 5
NCBI Official Synonym Full Names
DnaJ (Hsp40) homolog, subfamily C, member 5
NCBI Official Symbol
DNAJC5
NCBI Official Synonym Symbols
CSP; NCL; CLN4; CLN4B; DNAJC5A
UniProt Protein Name
DnaJ homolog subfamily C member 5
UniProt Synonym Protein Names
Cysteine string protein; CSP
Protein Family
DnaJ homolog subfamily
UniProt Gene Name
DNAJC5
UniProt Synonym Gene Names
CSP; CSP
UniProt Entry Name
DNJC5_HUMAN
NCBI Protein Information
dnaJ homolog subfamily C member 5; cysteine string protein alpha

NCBI Summary for DNAJC5

This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]
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UniProt Comments for DNAJC5

DNAJC5: a cysteine string protein that inhibits N-type calcium channels which is blocked by huntingtin mutants. May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings. Modulates the maturation of cystic fibrosis transmembrane conductance regulator. Two splice-variant isoforms have been described.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: synaptic vesicle; mitochondrion; membrane; lysosomal membrane; melanosome; plasma membrane

Molecular Function: ATP-dependent protein binding; glycoprotein binding

Biological Process: regulated secretory pathway; synaptic transmission; synaptic vesicle exocytosis; exocytosis; neurotransmitter secretion; negative regulation of neuron apoptosis
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Research Articles on DNAJC5

1. Missense mutations in DNAJC5 does not play a major role in PD in the Chinese population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DNAJC5 antibody

 Products by Pathway  Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram

Diseases associated with anti-DNAJC5 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >8 publications with DNAJC5 and Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with DNAJC5 and Brain Diseases
 Central Nervous System Diseases Antibodies  >3 publications with DNAJC5 and Central Nervous System Diseases
 Seizures Antibodies  >3 publications with DNAJC5 and Seizures
 Epilepsy, Tonic-Clonic Antibodies  >2 publications with DNAJC5 and Epilepsy, Tonic-Clonic
 Nerve Degeneration Antibodies  >1 publications with DNAJC5 and Nerve Degeneration
 Cognition Disorders Antibodies  >1 publications with DNAJC5 and Cognition Disorders

Organs/Tissues associated with anti-DNAJC5 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with DNAJC5 and Brain
 Nerve Antibodies  >2 publications with DNAJC5 and Nerve
 Muscle Antibodies  >1 publications with DNAJC5 and Muscle
 Skin Antibodies  >1 publications with DNAJC5 and Skin
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