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CNGA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248484

MBS248484 is an antibody targeting CNGA2. Also known as Rabbit Polyclonal to Human CNGA2. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CNGA2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human CNGA2
Product Gene Name
anti-CNGA2 antibody
Product Synonym Names
Anti-CNGA2 Antibody (aa189-218) IHC-plus; CNGA2; CNCA; CNCG2; CNCA1; CNCalpha2; CNG channel alpha-2; CNG-2; CNG2; OCNC1; OCNCALPHA; OCNCa; Human CNGA2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity Purified
Specificity
Human CNGA2
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
76,048 Da
OMIM
300338
3D Structure
ModBase 3D Structure for Q16280
Target Species
Human
Immunogen Description
KLH-conjugated synthetic peptide from N-terminal region of human CNGA2.
Immunogen Type
Synthetic peptide
Immunogen
CNGA2 antibody was raised against kLH-conjugated synthetic peptide from N-terminal region of human CNGA2.
Antigen Modification
aa189-218

Product Categories/Family for anti-CNGA2 antibody

Family: Ion Channel; Subfamily: Cyclic nucleotide gated channel
Applications Tested/Suitable for anti-CNGA2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-CNGA2 antibody
IHC-P (1:100), WB (1:1000)

Immunohistochemistry (IHC) of anti-CNGA2 antibody

Anti-CNGA2 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Rabbit Anti-CNGA2 Polyclonal Antibody – Cat# MBS248484

Western Blot (WB) of anti-CNGA2 antibody

CNGA2 Antibody (N-term) Western blot of mouse spleen tissue lysates (35 ug/lane). This demonstrates the CNGA2 antibody detected the CNGA2 protein (arrow).
Rabbit Anti-CNGA2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248484

Other Notes

Small volumes of anti-CNGA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CNGA2. It may not necessarily be applicable to this product.

NCBI GI #
42718011
NCBI GeneID
1260
NCBI Accession #
NP_005131.1
UniProt Primary Accession #
Q16280
UniProt Secondary Accession #
A0AVD0
UniProt Related Accession #
Q16280
GenBank Nucleotide #
NM_005140.1
NCBI Official Full Name
cyclic nucleotide-gated olfactory channel
NCBI Official Synonym Full Names
cyclic nucleotide gated channel alpha 2
NCBI Official Symbol
CNGA2
NCBI Official Synonym Symbols
CNCA; CNG2; CNCA1; OCNC1; OCNCa; OCNCALPHA
UniProt Protein Name
Cyclic nucleotide-gated olfactory channel
UniProt Synonym Protein Names
Cyclic nucleotide-gated cation channel 2; Cyclic nucleotide-gated channel alpha-2; CNG channel alpha-2; CNG-2; CNG2
Protein Family
Cyclic nucleotide-gated olfactory channel
UniProt Gene Name
CNGA2
UniProt Synonym Gene Names
CNCA; CNCA1; CNCG2; CNG channel alpha-2; CNG-2; CNG2
UniProt Entry Name
CNGA2_HUMAN
NCBI Protein Information
cyclic nucleotide-gated olfactory channel; CNG-2; CNG channel alpha-2; cyclic nucleotide-gated channel alpha-2; cyclic nucleotide-gated cation channel 2; cyclic-nucleotide-gated cation channel 2; cyclic-nucleotide-gated olfactory channel

NCBI Summary for CNGA2

The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]

UniProt Comments for CNGA2

CNGA2: Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq27

Cellular Component: Golgi membrane; integral to plasma membrane

Molecular Function: calmodulin binding; voltage-gated potassium channel activity; intracellular cGMP activated cation channel activity; cGMP binding; cAMP binding

Biological Process: phototransduction, visible light; regulation of membrane potential; organelle organization and biogenesis; sensory perception of smell
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Research Articles on CNGA2

1. The results showed that it is predominantly the charge of the E342 residue in the P-loop, rather than the pore helix dipoles, which controls the cation-anion selectivity of the CNGA2 channel.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CNGA2 antibody

 Reference Product  PubMed Publications
 CNGB1 antibody  >3 publications with CNGA2 and CNGB1
 KIRREL2 antibody  >2 publications with CNGA2 and KIRREL2
 ADCY3 antibody  >1 publications with CNGA2 and ADCY3
 BEST2 antibody  >1 publications with CNGA2 and BEST2

Pathways associated with anti-CNGA2 antibody

 Products by Pathway  Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cargo Trafficking To The Periciliary Membrane Pathway antibodies  Cargo Trafficking To The Periciliary Membrane Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram
 VxPx Cargo-targeting To Cilium Pathway antibodies  VxPx Cargo-targeting To Cilium Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram

Diseases associated with anti-CNGA2 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with CNGA2 and Brain Diseases
 Death Antibodies  >1 publications with CNGA2 and Death
 Nervous System Diseases Antibodies  >1 publications with CNGA2 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1 publications with CNGA2 and Cardiovascular Diseases
 Weight Loss Antibodies  >1 publications with CNGA2 and Weight Loss
 Lung Diseases Antibodies  >1 publications with CNGA2 and Lung Diseases
 Edema Antibodies  >1 publications with CNGA2 and Edema
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