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ACKR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248507

Human Chemokine Receptor D6 is activated by beta chemokines (CC motif) such as Monocyte chemoattractant protein (MCP), mucosae-associated epithelial chemokine (MEC) and keratinocyte-expressed cutaneous T cell-attracting chemokine (CTACK; CCL27). Two… More details

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Product Overview

Product Name
ACKR2 / CCR10 / D6, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6
Product Gene Name
anti-ACKR2 antibody
Product Synonym Gene Name
CCR10; D6
Product Synonym Names
Anti-ACKR2 / CCR10 / D6 Antibody (aa335-384) IHC-plus; ACKR2; C-C chemokine receptor D6; CCBP2; Chemokine (C-C) receptor 9; Chemokine binding protein 2; C-C chemokine receptor 10; Chemokine-binding protein 2; CMKBR9; Chemokine receptor CCR-9; G protein coupled receptor d6; HD6; Human ACKR2; CCR10; D6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
CCBP2 Antibody detects endogenous levels of total CCBP2 protein.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
43,443 Da
OMIM
602648
3D Structure
ModBase 3D Structure for O00590
Target Species
Human
Immunogen Description
Synthetic peptide from human CCBP2 (aa335-384).
Immunogen
ACKR2 / CCR10 / D6 antibody was raised against synthetic peptide from human CCBP2 (aa335-384).
Antigen Modification
aa335-384

Product Categories/Family for anti-ACKR2 antibody

Family: GPCR; Subfamily: Chemokine
Applications Tested/Suitable for anti-ACKR2 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-ACKR2 antibody
ELISA (1:1000), IF (1:100 - 1:500), IHC-P (5 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-ACKR2 antibody

Anti-ACKR2 / CCR10 / D6 antibody IHC staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-ACKR2 Polyclonal Antibody – Cat# MBS248507

Immunofluorescence (IF) of anti-ACKR2 antibody

Immunofluorescence of COS7 cells, using CCBP2 Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-ACKR2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS248507

Western Blot (WB) of anti-ACKR2 antibody

Western blot of extracts from HepG2 cells, using CCBP2 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-ACKR2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248507

Other Notes

Small volumes of anti-ACKR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACKR2 purchase

MBS248507 is an antibody targeting ACKR2. Also known as Rabbit Polyclonal (IgG) to Human ACKR2 / CCR10 / D6. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACKR2. It may not necessarily be applicable to this product.

NCBI GI #
13929467
NCBI GeneID
1238
NCBI Accession #
NP_001287.2
UniProt Primary Accession #
O00590
UniProt Secondary Accession #
O00537; Q53YA1; Q86UN9; Q96A02; B2R8Y8
UniProt Related Accession #
O00590
GenBank Nucleotide #
NM_001296.4
NCBI Official Full Name
atypical chemokine receptor 2
NCBI Official Synonym Full Names
atypical chemokine receptor 2
NCBI Official Symbol
ACKR2
NCBI Official Synonym Symbols
D6; hD6; CCR9; CCBP2; CCR10; CMKBR9
UniProt Protein Name
Atypical chemokine receptor 2
UniProt Synonym Protein Names
C-C chemokine receptor D6; Chemokine receptor CCR-10; Chemokine receptor CCR-9; Chemokine-binding protein 2; Chemokine-binding protein D6
Protein Family
Atypical chemokine receptor
UniProt Gene Name
ACKR2
UniProt Synonym Gene Names
CCBP2; CCR10; CMKBR9; D6
UniProt Entry Name
ACKR2_HUMAN
NCBI Protein Information
atypical chemokine receptor 2; chemokine receptor D6; chemokine receptor CCR-9; C-C chemokine receptor D6; chemokine receptor CCR-10; chemokine (C-C) receptor 9; chemokine binding protein 2; chemokine-binding protein 2; chemokine-binding protein D6; chemokine (C-C motif) receptor 9; CC-chemokine-binding receptor JAB61

NCBI Summary for ACKR2

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]
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UniProt Comments for ACKR2

CCBP2: Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: recycling endosome; integral to plasma membrane; early endosome; plasma membrane; actin filament

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; scavenger receptor activity; C-X-C chemokine receptor activity

Biological Process: receptor-mediated endocytosis; G-protein coupled receptor protein signaling pathway; neutrophil activation; multicellular organismal development; immune response; chemotaxis; inflammatory response
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Research Articles on ACKR2

1. Data show the structural motifs in the atypical chemokine receptor 2 (ACKR2) are responsible for ligand binding, and suggest ACKR2-derived N-terminal peptides as being of potential therapeutic significance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ACKR2 antibody

 Reference Product  PubMed Publications
 CCL7 antibody  >1 publications with ACKR2 and CCL7

Pathways associated with anti-ACKR2 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-ACKR2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with ACKR2 and Inflammation
 Weight Loss Antibodies  >1 publications with ACKR2 and Weight Loss
 Fetal Death Antibodies  >1 publications with ACKR2 and Fetal Death

Organs/Tissues associated with anti-ACKR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >1 publications with ACKR2 and Placenta
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