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COUP-TFII Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248579

COUP-TFII, a NR2 Hepatocyte NF4-Like receptor, has been shown to affect neuronal development and differentiation, homeostasis in various human tissues, mesenchymal-epithelial interactions during organogenesis, and the development of the cardiovascular system.… More details

$650 / 0.2 mL +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
COUP-TFII / NR2F2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human COUP-TFII / NR2F2
Product Gene Name
anti-COUP-TFII antibody
Product Synonym Gene Name
NR2F2
Product Synonym Names
Anti-COUP-TFII / NR2F2 Antibody (aa1-30) IHC-plus; NR2F2; ARP1; ARP-1; COUP transcription factor II; COUP-TF II; COUP-TF2; COUP-TFII; COUPTFB; COUPTFII; COUP transcription factor 2; EAR3; NF-E3; SVP40; COUPTF-II; TFCOUP2; Human COUP-TFII; NR2F2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity Purified
Specificity
Human COUP-TFII / NR2F2
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
29,163 Da
OMIM
gene 615779
3D Structure
ModBase 3D Structure for P24468
Target Species
Human
Immunogen Description
KLH-conjugated synthetic peptide from N-terminal region of human NR2F2.
Immunogen Type
Synthetic peptide
Immunogen
COUP-TFII / NR2F2 antibody was raised against kLH-conjugated synthetic peptide from N-terminal region of human NR2F2.
Antigen Modification
aa1-30

Product Categories/Family for anti-COUP-TFII antibody

Family: NHR; Subfamily: NR2 Hepatocyte NF4-like
Applications Tested/Suitable for anti-COUP-TFII antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-COUP-TFII antibody
IHC-P (1:50), WB (1:1000)

Immunohistochemistry (IHC) of anti-COUP-TFII antibody

Anti-COUP-TFII / NR2F2 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Rabbit Anti-COUP-TFII Polyclonal Antibody – Cat# MBS248579

Western Blot (WB) of anti-COUP-TFII antibody

NR2F2 Antibody (N-term) Western blot of HepG2 and NIH/3T3 cell line lysates (35 ug/lane). This demonstrates the NR2F2 antibody detected the NR2F2 protein (arrow).
Rabbit Anti-COUP-TFII Polyclonal Antibody, Western Blot (WB) – Cat# MBS248579

Other Notes

Small volumes of anti-COUP-TFII antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COUP-TFII purchase

MBS248579 is an antibody targeting COUP-TFII. Also known as Rabbit Polyclonal to Human COUP-TFII / NR2F2. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for COUP-TFII. It may not necessarily be applicable to this product.

NCBI GI #
14149746
NCBI GeneID
7026
NCBI Accession #
NP_066285.1
UniProt Primary Accession #
P24468
UniProt Secondary Accession #
Q03754; Q3KQR7; B4DQJ2; B6ZGU1
UniProt Related Accession #
P24468
GenBank Nucleotide #
NM_021005.3
NCBI Official Full Name
COUP transcription factor 2 isoform a
NCBI Official Synonym Full Names
nuclear receptor subfamily 2, group F, member 2
NCBI Official Symbol
NR2F2
NCBI Official Synonym Symbols
ARP1; CHTD4; NF-E3; NR2F1; SVP40; COUPTFB; TFCOUP2; COUPTFII
UniProt Protein Name
COUP transcription factor 2
UniProt Synonym Protein Names
Apolipoprotein A-I regulatory protein 1; ARP-1; COUP transcription factor II; COUP-TF II; Nuclear receptor subfamily 2 group F member 2
UniProt Gene Name
NR2F2
UniProt Synonym Gene Names
ARP1; TFCOUP2; COUP-TF2; ARP-1; COUP-TF II
UniProt Entry Name
COT2_HUMAN
NCBI Protein Information
COUP transcription factor 2; COUP transcription factor II; apolipoprotein AI regulatory protein 1; apolipoprotein A-I regulatory protein 1; ADP-ribosylation factor related protein 1; chicken ovalbumin upstream promoter transcription factor 2; chicken ovalbumin upstream promoter-transcription factor I

NCBI Summary for COUP-TFII

This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
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UniProt Comments for COUP-TFII

NR2F2: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2. Ubiquitous. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 15q26

Cellular Component: nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor activity; retinoic acid binding; protein homodimerization activity; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity; transcription corepressor activity

Biological Process: limb development; skeletal muscle development; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; neuron migration; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; signal transduction; response to estradiol stimulus; anterior/posterior pattern formation; regulation of transcription from RNA polymerase II promoter; fertilization; negative regulation of endothelial cell proliferation; forebrain development; blood vessel morphogenesis; steroid hormone mediated signaling; lipid metabolic process; negative regulation of transcription, DNA-dependent; radial pattern formation; maternal placenta development

Disease: Congenital Heart Defects, Multiple Types, 4
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Research Articles on COUP-TFII

1. Overexpression of COUP-TFII was required for cancer cells to metastasise in vivo.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-COUP-TFII antibody

 Reference Product  PubMed Publications
 APOB antibody  >5 publications with COUP-TFII and APOB
 TERT antibody  >2 publications with COUP-TFII and TERT
 RXRA antibody  >1 publications with COUP-TFII and RXRA
 KLF4 antibody  >1 publications with COUP-TFII and KLF4
 BCL11B antibody  >1 publications with COUP-TFII and BCL11B
 RERE antibody  >1 publications with COUP-TFII and RERE

Pathways associated with anti-COUP-TFII antibody

 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Transcriptional Regulation Of White Adipocyte Differentiation Pathway antibodies  Transcriptional Regulation Of White Adipocyte Differentiation Pathway Diagram

Diseases associated with anti-COUP-TFII antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >9 publications with COUP-TFII and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >8 publications with COUP-TFII and Cardiovascular Diseases
 Heart Diseases Antibodies  >6 publications with COUP-TFII and Heart Diseases
 Hernia, Diaphragmatic Antibodies  >6 publications with COUP-TFII and Hernia, Diaphragmatic
 Liver Neoplasms Antibodies  >5 publications with COUP-TFII and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >5 publications with COUP-TFII and Carcinoma, Hepatocellular
 Neoplasm Metastasis Antibodies  >5 publications with COUP-TFII and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >5 publications with COUP-TFII and Breast Neoplasms
 Liver Diseases Antibodies  >4 publications with COUP-TFII and Liver Diseases
 Disease Models, Animal Antibodies  >3 publications with COUP-TFII and Disease Models, Animal

Organs/Tissues associated with anti-COUP-TFII antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >34 publications with COUP-TFII and Liver
 Thyroid Antibodies  >23 publications with COUP-TFII and Thyroid
 Vascular Antibodies  >22 publications with COUP-TFII and Vascular
 Muscle Antibodies  >19 publications with COUP-TFII and Muscle
 Brain Antibodies  >19 publications with COUP-TFII and Brain
 Embryonic Tissue Antibodies  >17 publications with COUP-TFII and Embryonic Tissue
 Ear Antibodies  >16 publications with COUP-TFII and Ear
 Heart Antibodies  >14 publications with COUP-TFII and Heart
 Lung Antibodies  >11 publications with COUP-TFII and Lung
 Bone Antibodies  >8 publications with COUP-TFII and Bone
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