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TLX1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248586

MBS248586 is an antibody targeting TLX1. Also known as Rabbit Polyclonal to Human TLX1 / HOX11. Reactive in Human, Mouse. Host: Rabbit. More details

$650 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TLX1 / HOX11, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human TLX1 / HOX11
Product Gene Name
Product Synonym Gene Name
HOX11
Product Synonym Names
Anti-TLX1 / HOX11 Antibody (aa162-191) IHC-plus; TLX1; Homeobox protein Hox-11; HOX11; T-cell leukemia homeobox 1; Proto-oncogene TCL-3; TCL3; T-cell leukemia; homeobox 1; Human TLX1; HOX11
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity Purified
Specificity
Human HOX11
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
26,245 Da
OMIM
186770
3D Structure
ModBase 3D Structure for P31314
Target Species
Human
Immunogen Description
KLH-conjugated synthetic peptide from internal region of human TLX1.
Immunogen Type
Synthetic peptide
Immunogen
TLX1 / HOX11 antibody was raised against kLH-conjugated synthetic peptide from internal region of human TLX1.
Antigen Modification
aa162-191
Applications Tested/Suitable for anti-TLX1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-TLX1 antibody
IHC-P (1:50), WB (1:1000)

Immunohistochemistry (IHC) of anti-TLX1 antibody

Anti-TLX1 / HOX11 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Rabbit Anti-TLX1 Polyclonal Antibody – Cat# MBS248586

Western Blot (WB) of anti-TLX1 antibody

TLX1 Antibody (Center) Western blot of mouse kidney tissue lysates (35 ug/lane). This demonstrates the TLX1 antibody detected the TLX1 protein (arrow).
Rabbit Anti-TLX1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248586

Other Notes

Small volumes of anti-TLX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TLX1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
T-cell leukemia homeobox protein 1 isoform 1
NCBI Official Synonym Full Names
T-cell leukemia homeobox 1
NCBI Official Symbol
TLX1
NCBI Official Synonym Symbols
TCL3; HOX11
UniProt Protein Name
T-cell leukemia homeobox protein 1
UniProt Synonym Protein Names
Homeobox protein Hox-11; Proto-oncogene TCL-3; T-cell leukemia/lymphoma protein 3
UniProt Gene Name
TLX1
UniProt Synonym Gene Names
HOX11; TCL3
UniProt Entry Name
TLX1_HUMAN
NCBI Protein Information
T-cell leukemia homeobox protein 1; proto-oncogene TCL-3; homeobox protein Hox-11; T-cell leukemia/lymphoma protein 3; homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch)

NCBI Summary for TLX1

This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
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UniProt Comments for TLX1

TLX1: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: nucleus

Molecular Function: protein binding; protein heterodimerization activity; sequence-specific DNA binding

Biological Process: spleen development; neuron differentiation; organ formation; central nervous system development; cell fate commitment; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-TLX1 antibody

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