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KLF8 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248604

MBS248604 is an antibody targeting KLF8. Also known as Goat Polyclonal to Human KLF8. Reactive in HumanPredicted Reactivity: Monkey (at least 90% immunogen sequence identity). Host: Goat. More details

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Product Overview

Product Name
KLF8, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human KLF8
Product Gene Name
anti-KLF8 antibody
Product Synonym Names
Anti-KLF8 Antibody (N-Terminus) IHC-plus; KLF8; Basic kruppel-like factor 3; BKLF3; DXS741; Krueppel-like factor 8; Kruppel-like factor 8; Zinc finger protein 741; Basic krueppel-like factor 3; ZNF741; Human KLF8
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human KLF8. This antibody is expected to recognise isoform 1 (NP_009181.2) and isoform 2 (NP_001152768.1).
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
30,050 Da
OMIM
300286
3D Structure
ModBase 3D Structure for O95600
Target Species
Human
Immunogen Description
Synthetic peptide VDMDKLINNLEVQ-C from the N-terminus of human KLF8 (NP_009181.2; NP_001152768.1). Percent identity with other species by BLAST analysis: Human (100%), Marmoset (92%), Gorilla (85%), Gibbon (85%), Monkey (85%), Rabbit (85%), Pig (85%).
Immunogen Type
Synthetic peptide
Immunogen
KLF8 antibody was raised against synthetic peptide VDMDKLINNLEVQ-C from the N-terminus of human KLF8 (NP_009181.2; NP_001152768.1). Percent identity with other species by BLAST analysis: Human (100%), Marmoset (92%), Gorilla (85%), Gibbon (85%), Monkey (85%), Rabbit (85%), Pig (85%).
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-KLF8 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-KLF8 antibody
ELISA, IHC-P (3.75 ug/ml), WB (1 - 3 ug/ml)

Immunohistochemistry (IHC) of anti-KLF8 antibody

Anti-KLF8 antibody IHC staining of human small intestine, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Goat Anti-KLF8 Polyclonal Antibody – Cat# MBS248604

Western Blot (WB) of anti-KLF8 antibody

Staining (2 ug/ml) of Human Kidney lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by chemiluminescence.
Goat Anti-KLF8 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248604

Other Notes

Small volumes of anti-KLF8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KLF8. It may not necessarily be applicable to this product.

NCBI GI #
89111943
NCBI GeneID
11279
NCBI Accession #
NP_009181.2
UniProt Primary Accession #
O95600
UniProt Secondary Accession #
Q2M246; Q59GV5; Q5HYQ5; Q5JXP7; Q6MZJ7; Q9UGC4; B4DJN3; E7EQQ8; L0R3U8; L0R4U2
UniProt Related Accession #
O95600
GenBank Nucleotide #
NM_007250.4
NCBI Official Full Name
Krueppel-like factor 8 isoform 1
NCBI Official Synonym Full Names
Kruppel-like factor 8
NCBI Official Symbol
KLF8
NCBI Official Synonym Symbols
BKLF3; ZNF741
UniProt Protein Name
Krueppel-like factor 8
UniProt Synonym Protein Names
Basic krueppel-like factor 3; Zinc finger protein 741
Protein Family
Krueppel-like factor
UniProt Gene Name
KLF8
UniProt Synonym Gene Names
BKLF3; ZNF741
UniProt Entry Name
KLF8_HUMAN
NCBI Protein Information
Krueppel-like factor 8; zinc finger protein 741; basic kruppel-like factor 3; basic krueppel-like factor 3

NCBI Summary for KLF8

This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
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UniProt Comments for KLF8

KLF8: Transcriptional repressor and activator. Binds to CACCC- boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). Belongs to the Sp1 C2H2-type zinc-finger protein family.

Protein type: DNA-binding; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: Xp11.21

Cellular Component: nucleus

Molecular Function: DNA binding; metal ion binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
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Research Articles on KLF8

1. A novel KLF8 to EPSTI1 to VCP to NF-kappaB signaling mechanism potentially critical for breast cancer invasion and metastasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KLF8 antibody

 Reference Product  PubMed Publications
 CCND1 antibody  >11 publications with KLF8 and CCND1
 CDH1 antibody  >3 publications with KLF8 and CDH1
 PARP1 antibody  >2 publications with KLF8 and PARP1
 CTBP2 antibody  >1 publications with KLF8 and CTBP2

Pathways associated with anti-KLF8 antibody

 Products by Pathway  Pathway Diagram
 Signaling Events Mediated By Focal Adhesion Kinase Pathway antibodies  Signaling Events Mediated By Focal Adhesion Kinase Pathway Diagram

Diseases associated with anti-KLF8 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >6 publications with KLF8 and Adenocarcinoma
 Lung Diseases Antibodies  >4 publications with KLF8 and Lung Diseases
 Nervous System Diseases Antibodies  >3 publications with KLF8 and Nervous System Diseases
 Lung Neoplasms Antibodies  >3 publications with KLF8 and Lung Neoplasms
 Ovarian Diseases Antibodies  >2 publications with KLF8 and Ovarian Diseases
 Heart Diseases Antibodies  >1 publications with KLF8 and Heart Diseases
 Neoplasms, Experimental Antibodies  >1 publications with KLF8 and Neoplasms, Experimental
 Brain Diseases Antibodies  >1 publications with KLF8 and Brain Diseases
 Kidney Diseases Antibodies  >1 publications with KLF8 and Kidney Diseases

Organs/Tissues associated with anti-KLF8 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >6 publications with KLF8 and Lung
 Lymph Node Antibodies  >3 publications with KLF8 and Lymph Node
 Placenta Antibodies  >3 publications with KLF8 and Placenta
 Brain Antibodies  >3 publications with KLF8 and Brain
 Embryonic Tissue Antibodies  >3 publications with KLF8 and Embryonic Tissue
 Kidney Antibodies  >3 publications with KLF8 and Kidney
 Prostate Antibodies  >2 publications with KLF8 and Prostate
 Vascular Antibodies  >2 publications with KLF8 and Vascular
 Mouth Antibodies  >1 publications with KLF8 and Mouth
 Uterus Antibodies  >1 publications with KLF8 and Uterus
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