• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Alpha-1-Antichymotrypsin (SERPINA3) Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248619

MBS248619 is an antibody targeting SERPINA3. Also known as Goat Polyclonal to Human Alpha-1-Antichymotrypsin. Reactive in Chimpanzee, Human. Host: Goat. More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
Alpha-1-Antichymotrypsin (SERPINA3), Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human Alpha-1-Antichymotrypsin
Product Gene Name
Product Synonym Names
Anti-Alpha-1-Antichymotrypsin Antibody (aa222-236) IHC-plus; Alpha-1-antichymotrypsin; AACT; GIG25; Growth-inhibiting protein 25; GIG24; Serpin A3; Growth-inhibiting protein 24; Human Alpha-1-Antichymotrypsin
Clonality
Polyclonal
Host
Goat
Species Reactivity
Chimpanzee, Human
Form/Format
Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human SERPINA3.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
10,717 Da
OMIM
107280
3D Structure
ModBase 3D Structure for P01011
Target Species
Human
Immunogen Description
Synthetic peptide C-DPQDTHQSRFYLSKK from an internal region of human SERPINA3 (NP_001076.2). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Gibbon (87%); Mouse, Rat (60%).
Immunogen Type
Synthetic peptide
Immunogen
Alpha-1-Antichymotrypsin antibody was raised against synthetic peptide C-DPQDTHQSRFYLSKK from an internal region of human SERPINA3 (NP_001076.2). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Gibbon (87%); Mouse, Rat (60%).
Antigen Modification
aa222-236
Applications Tested/Suitable for anti-SERPINA3 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-SERPINA3 antibody
ELISA (1:128000), IHC-P (5 ug/ml), WB (0.3 - 1 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:128000. Western blot: Approx 65kD band observed in Human Albumin-depleted Serum and Plasma lysates (calculated MW of 47.7kD according to NP_001076.2). The observed molecular weight corresponds to the...

Immunohistochemistry (IHC) of anti-SERPINA3 antibody

Anti-Alpha-1-Antichymotrypsin antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Goat Anti-SERPINA3 Polyclonal Antibody – Cat# MBS248619

Western Blot (WB) of anti-SERPINA3 antibody

SERPINA3 antibody (0.3 ug/ml) staining of albumin-depleted Serum (A) and Plasma(B) lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-SERPINA3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248619

Other Notes

Small volumes of anti-SERPINA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPINA3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
alpha-1-antichymotrypsin
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
NCBI Official Symbol
SERPINA3
NCBI Official Synonym Symbols
ACT; AACT; GIG24; GIG25
UniProt Protein Name
Alpha-1-antichymotrypsin
UniProt Synonym Protein Names
Cell growth-inhibiting gene 24/25 protein; Serpin A3Alpha-1-antichymotrypsin His-Pro-less
UniProt Gene Name
SERPINA3
UniProt Synonym Gene Names
AACT; ACT
UniProt Entry Name
AACT_HUMAN
NCBI Protein Information
alpha-1-antichymotrypsin; serpin A3; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3

NCBI Summary for SERPINA3

The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for SERPINA3

SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: extracellular space; extracellular region; intracellular; nucleus

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; DNA binding

Biological Process: regulation of lipid metabolic process; maintenance of gastrointestinal epithelium; acute-phase response; inflammatory response
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SERPINA3 antibody

 Products by Pathway  Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000