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TGIF2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248645

MBS248645 is an antibody targeting TGIF2. Also known as Goat Polyclonal to Human TGIF2. Reactive in Gibbon, Dog, Gorilla, Horse, Human, Monkey, Pig, Rat. Host: Goat. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
TGIF2, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human TGIF2
Product Gene Name
anti-TGIF2 antibody
Product Synonym Names
Anti-TGIF2 Antibody (Internal) IHC-plus; TGIF2; 5-TG-3-interacting factor 2; 5-TG-3 interacting factor 2; Homeobox protein TGIF2; TGF beta induced factor 2; TGFB-induced factor 2; TGFB-induced factor homeobox 2; Human TGIF2
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Dog, Gorilla, Horse, Human, Monkey, Pig, Rat
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Specificity
Human TGIF2.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
17,908 Da
OMIM
607294
3D Structure
ModBase 3D Structure for Q9GZN2
Target Species
Human
Immunogen Description
Synthetic peptide C-EMELQKQQDP from an internal region of human TGIF2 (NP_068581.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rat, Elephant, Panda, Dog, Horse, Pig (100%); Mouse, Hamster, Bat, Bovine, Rabbit (90%)
Immunogen Type
Synthetic peptide
Immunogen
TGIF2 antibody was raised against synthetic peptide C-EMELQKQQDP from an internal region of human TGIF2 (NP_068581.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rat, Elephant, Panda, Dog, Horse, Pig (100%); Mouse, Hamster, Bat, Bovine, Rabbit (90%); Slime mold, Paramecium, Chaetomium, Salpingoeca (80%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-TGIF2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-TGIF2 antibody
ELISA (1:16000), IHC-P (5 ug/ml), WB (0.3 - 1 ug/ml)

Immunohistochemistry (IHC) of anti-TGIF2 antibody

Anti-TGIF2 antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Goat Anti-TGIF2 Polyclonal Antibody – Cat# MBS248645

Western Blot (WB) of anti-TGIF2 antibody

Antibody (0.3 ug/ml) staining of A431 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-TGIF2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248645

Other Notes

Small volumes of anti-TGIF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TGIF2. It may not necessarily be applicable to this product.

NCBI GI #
11141881
NCBI GeneID
60436
NCBI Accession #
NP_068581.1
UniProt Primary Accession #
Q9GZN2
UniProt Secondary Accession #
B2R9U3; E1P5T9; H0YNI0
UniProt Related Accession #
Q9GZN2
GenBank Nucleotide #
NM_021809.6
NCBI Official Full Name
homeobox protein TGIF2
NCBI Official Synonym Full Names
TGFB-induced factor homeobox 2
NCBI Official Symbol
TGIF2
UniProt Protein Name
Homeobox protein TGIF2
UniProt Synonym Protein Names
5'-TG-3'-interacting factor 2; TGF-beta-induced transcription factor 2; TGFB-induced factor 2
Protein Family
Homeobox protein
UniProt Gene Name
TGIF2
UniProt Synonym Gene Names
TGFB-induced factor 2
UniProt Entry Name
TGIF2_HUMAN
NCBI Protein Information
homeobox protein TGIF2; 5'-TG-3' interacting factor 2; TGF-beta-induced transcription factor 2; TGF(beta)-induced transcription factor 2; TGFB-induced factor 2 (TALE family homeobox); transcription growth factor-beta-induced factor 2

NCBI Summary for TGIF2

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]
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UniProt Comments for TGIF2

TGIF2: Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins. Belongs to the TALE/TGIF homeobox family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: nucleoplasm; centrosome; nucleus

Molecular Function: DNA binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription, DNA-dependent; retina development in camera-type eye; transforming growth factor beta receptor signaling pathway; regulation of gastrulation; gene expression; negative regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation
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Research Articles on TGIF2

1. Shows that the homologous mouse Tgif2 gene is necessary for gastrulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TGIF2 antibody

 Reference Product  PubMed Publications
 TGIF1 antibody  >10 publications with TGIF2 and TGIF1
 PABPC5 antibody  >1 publications with TGIF2 and PABPC5
 SMAD4 antibody  >1 publications with TGIF2 and SMAD4
 HDAC1 antibody  >1 publications with TGIF2 and HDAC1

Pathways associated with anti-TGIF2 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway antibodies  Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Loss Of Function Of SMAD2/3 In Cancer Pathway antibodies  Loss Of Function Of SMAD2/3 In Cancer Pathway Diagram
 Loss Of Function Of SMAD4 In Cancer Pathway antibodies  Loss Of Function Of SMAD4 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR1 In Cancer Pathway antibodies  Loss Of Function Of TGFBR1 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR2 In Cancer Pathway antibodies  Loss Of Function Of TGFBR2 In Cancer Pathway Diagram
 Regulation Of Nuclear SMAD2/3 Signaling Pathway antibodies  Regulation Of Nuclear SMAD2/3 Signaling Pathway Diagram
 SMAD2/3 MH2 Domain Mutants In Cancer Pathway antibodies  SMAD2/3 MH2 Domain Mutants In Cancer Pathway Diagram

Organs/Tissues associated with anti-TGIF2 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >6 publications with TGIF2 and Testis
 Brain Antibodies  >6 publications with TGIF2 and Brain
 Liver Antibodies  >4 publications with TGIF2 and Liver
 Bone Antibodies  >3 publications with TGIF2 and Bone
 Lymph Node Antibodies  >3 publications with TGIF2 and Lymph Node
 Lymph Antibodies  >3 publications with TGIF2 and Lymph
 Ovary Antibodies  >2 publications with TGIF2 and Ovary
 Embryonic Tissue Antibodies  >2 publications with TGIF2 and Embryonic Tissue
 Eye Antibodies  >2 publications with TGIF2 and Eye
 Pancreas Antibodies  >2 publications with TGIF2 and Pancreas
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