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TROP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248647

MBS248647 is an antibody targeting TROP2. Also known as Rabbit Polyclonal (IgG) to Human TROP2 / TACSTD2. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
TROP2 / TACSTD2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human TROP2 / TACSTD2
Product Gene Name
anti-TROP2 antibody
Product Synonym Gene Name
TACSTD2
Product Synonym Names
Anti-TROP2 / TACSTD2 Antibody (aa131-180) IHC-plus; TACSTD2; EGP-1; EGP1; GA7331; M1S1; TROP2; Epithelial glycoprotein-1; GA733-1; gp50; Human TROP2; TACSTD2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
TACD2 Antibody detects endogenous levels of total TACD2 protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
35,709 Da
OMIM
gene 204870
3D Structure
ModBase 3D Structure for P09758
Target Species
Human
Immunogen Description
Synthetic peptide from human TACD2 (aa131-180).
Immunogen
TROP2 / TACSTD2 antibody was raised against synthetic peptide from human TACD2 (aa131-180).
Antigen Modification
aa131-180
Applications Tested/Suitable for anti-TROP2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-TROP2 antibody
ELISA (1:5000), IHC-P (5 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-TROP2 antibody

Anti-TROP2 / TACSTD2 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-TROP2 Polyclonal Antibody – Cat# MBS248647

Western Blot (WB) of anti-TROP2 antibody

Western blot of extracts from A549/NIH-3T3 cells, using TACD2 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-TROP2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248647

Other Notes

Small volumes of anti-TROP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TROP2. It may not necessarily be applicable to this product.

NCBI GI #
166795236
NCBI GeneID
4070
NCBI Accession #
NP_002344.2
UniProt Primary Accession #
P09758
UniProt Secondary Accession #
Q15658; Q6FG48; Q7Z7Q4; Q96QD2
UniProt Related Accession #
P09758
GenBank Nucleotide #
NM_002353.2
NCBI Official Full Name
tumor-associated calcium signal transducer 2
NCBI Official Synonym Full Names
tumor-associated calcium signal transducer 2
NCBI Official Symbol
TACSTD2
NCBI Official Synonym Symbols
EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
UniProt Protein Name
Tumor-associated calcium signal transducer 2
UniProt Synonym Protein Names
Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1
UniProt Gene Name
TACSTD2
UniProt Synonym Gene Names
GA733-1; M1S1; TROP2
UniProt Entry Name
TACD2_HUMAN
NCBI Protein Information
tumor-associated calcium signal transducer 2; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733

NCBI Summary for TROP2

This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]

UniProt Comments for TROP2

TACSTD2: May function as a growth factor receptor. Defects in TACSTD2 are the cause of gelatinous drop-like corneal dystrophy (GDLD); also known as lattice corneal dystrophy type III. GDLD is an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment. Belongs to the EPCAM family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: extracellular space; membrane; integral to plasma membrane; basal plasma membrane; nucleus; cytosol; lateral plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: cell proliferation; cell surface receptor linked signal transduction; negative regulation of stress fiber formation; visual perception; regulation of epithelial cell proliferation

Disease: Corneal Dystrophy, Gelatinous Drop-like
Show more

Research Articles on TROP2

1. Inhibition of Tacstd2 expression significantly inhibited chemotherapeutic reagent-induced apoptosis, and TACSTD2 regulated apoptotic gene expression through P63 containing the transactivation domain (TAp63).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TROP2 antibody

 Reference Product  PubMed Publications
 CLDN7 antibody  >2 publications with TROP2 and CLDN7

Diseases associated with anti-TROP2 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >13 publications with TROP2 and Adenocarcinoma
 Prostatic Neoplasms Antibodies  >11 publications with TROP2 and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >11 publications with TROP2 and Prostatic Diseases
 Breast Neoplasms Antibodies  >10 publications with TROP2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >9 publications with TROP2 and Neoplasms, Experimental
 Carcinoma, Squamous Cell Antibodies  >7 publications with TROP2 and Carcinoma, Squamous Cell
 Corneal dystrophy, gelatinous drop-like Antibodies  >6 publications with TROP2 and Corneal dystrophy, gelatinous drop-like
 Ovarian Diseases Antibodies  >5 publications with TROP2 and Ovarian Diseases
 Disease Models, Animal Antibodies  >5 publications with TROP2 and Disease Models, Animal
 Ovarian Neoplasms Antibodies  >5 publications with TROP2 and Ovarian Neoplasms

Organs/Tissues associated with anti-TROP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >17 publications with TROP2 and Eye
 Prostate Antibodies  >13 publications with TROP2 and Prostate
 Liver Antibodies  >10 publications with TROP2 and Liver
 Lymph Node Antibodies  >9 publications with TROP2 and Lymph Node
 Lung Antibodies  >6 publications with TROP2 and Lung
 Bone Antibodies  >4 publications with TROP2 and Bone
 Skin Antibodies  >3 publications with TROP2 and Skin
 Bone Marrow Antibodies  >2 publications with TROP2 and Bone Marrow
 Intestine Antibodies  >2 publications with TROP2 and Intestine
 Cervix Antibodies  >2 publications with TROP2 and Cervix
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