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MTIF2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248652

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2… More details

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Product Overview

Online Datasheet in PDF
Product Name
MTIF2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human MTIF2
Product Gene Name
anti-MTIF2 antibody
Product Synonym Names
Anti-MTIF2 Antibody (aa137-167) IHC-plus; MTIF2; IF-2(Mt); IF-2mt; IF2(mt); Human MTIF2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity Purified
Specificity
Human MTIF2
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
81,317 Da
OMIM
603766
3D Structure
ModBase 3D Structure for P46199
Target Species
Human
Immunogen Description
KLH-conjugated synthetic peptide from N-terminal region of human MTIF2.
Immunogen Type
Synthetic peptide
Immunogen
MTIF2 antibody was raised against kLH-conjugated synthetic peptide from N-terminal region of human MTIF2.
Antigen Modification
aa137-167
Applications Tested/Suitable for anti-MTIF2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-MTIF2 antibody
IHC-P (1:100), WB (1:1000)

Immunohistochemistry (IHC) of anti-MTIF2 antibody

Anti-MTIF2 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Rabbit Anti-MTIF2 Polyclonal Antibody – Cat# MBS248652

Western Blot (WB) of anti-MTIF2 antibody

Western blot analysis of SK-BR-3 cell line lysate (35 ug/lane) using MTIF2 Antibody (N-term) at 1:1000 dilution.
Rabbit Anti-MTIF2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248652

Other Notes

Small volumes of anti-MTIF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MTIF2 purchase

MBS248652 is an antibody targeting MTIF2. Also known as Rabbit Polyclonal to Human MTIF2. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MTIF2. It may not necessarily be applicable to this product.

NCBI GI #
53729337
NCBI GeneID
4528
NCBI Accession #
NP_002444.2
UniProt Primary Accession #
P46199
UniProt Secondary Accession #
D6W5D0
UniProt Related Accession #
P46199
GenBank Nucleotide #
NM_002453.2
NCBI Official Full Name
translation initiation factor IF-2, mitochondrial
NCBI Official Synonym Full Names
mitochondrial translational initiation factor 2
NCBI Official Symbol
MTIF2
UniProt Protein Name
Translation initiation factor IF-2, mitochondrial
UniProt Gene Name
MTIF2
UniProt Synonym Gene Names
IF-2(Mt); IF-2Mt; IF2(mt)
UniProt Entry Name
IF2M_HUMAN
NCBI Protein Information
translation initiation factor IF-2, mitochondrial; IF-2mt; IF2(mt); IF-2(Mt)

NCBI Summary for MTIF2

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for MTIF2

MTIF2: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. Belongs to the IF-2 family.

Protein type: Translation initiation; Translation; Mitochondrial

Chromosomal Location of Human Ortholog: 2p16.1

Cellular Component: nucleoplasm; mitochondrion

Molecular Function: GTPase activity; GTP binding; translation factor activity, nucleic acid binding; translation initiation factor activity; ribosomal small subunit binding

Biological Process: mitochondrial translation; organelle organization and biogenesis; ribosome disassembly; regulation of translational initiation
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Research Articles on MTIF2

1. This study identified a novel GWS association (1.17 x 10(-10)) mapped to chromosome 2 at rs1437396, between MTIF2 and CCDC88A, across all of the EA and AA cohorts.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MTIF2 antibody

 Products by Pathway  Pathway Diagram
 Mitochondrial Translation Pathway antibodies  Mitochondrial Translation Pathway Diagram
 Mitochondrial Translation Initiation Pathway antibodies  Mitochondrial Translation Initiation Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram
 TNF-alpha/NF-kB Signaling Pathway antibodies  TNF-alpha/NF-kB Signaling Pathway Diagram

Organs/Tissues associated with anti-MTIF2 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1 publications with MTIF2 and Heart
 Testis Antibodies  >1 publications with MTIF2 and Testis
 Placenta Antibodies  >1 publications with MTIF2 and Placenta
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