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GGCT Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248661

MBS248661 is an antibody targeting GGCT. Also known as Rabbit Polyclonal to Human GGCT. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GGCT, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human GGCT
Product Gene Name
Product Synonym Names
Anti-GGCT Antibody (aa139-168) IHC-plus; GGCT; CRF21; GCTG; GGC; C7orf24; Gamma-glutamylcyclotransferase; Human GGCT
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity Purified
Specificity
Human GGCT
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
19,092 Da
OMIM
137170
3D Structure
ModBase 3D Structure for O75223
Target Species
Human
Immunogen Description
KLH-conjugated synthetic peptide from C-terminal region of human GGCT.
Immunogen Type
Synthetic peptide
Immunogen
GGCT antibody was raised against kLH-conjugated synthetic peptide from C-terminal region of human GGCT.
Antigen Modification
aa139-168
Applications Tested/Suitable for anti-GGCT antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-GGCT antibody
IHC-P (1:100), WB (1:1000)

Immunohistochemistry (IHC) of anti-GGCT antibody

Anti-GGCT antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Rabbit Anti-GGCT Polyclonal Antibody – Cat# MBS248661

Western Blot (WB) of anti-GGCT antibody

Western blot of GGCT Antibody (C-term) in 293 cell line lysates (35 ug/lane). GGCT (arrow) was detected using the purified Pab.
Rabbit Anti-GGCT Polyclonal Antibody, Western Blot (WB) – Cat# MBS248661

Other Notes

Small volumes of anti-GGCT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GGCT. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
gamma-glutamylcyclotransferase isoform 2
NCBI Official Synonym Full Names
gamma-glutamylcyclotransferase
NCBI Official Symbol
GGCT
NCBI Official Synonym Symbols
GGC; GCTG; CRF21; C7orf24
UniProt Protein Name
Gamma-glutamylcyclotransferase
UniProt Synonym Protein Names
Cytochrome c-releasing factor 21
UniProt Gene Name
GGCT
UniProt Synonym Gene Names
C7orf24; CRF21
UniProt Entry Name
GGCT_HUMAN
NCBI Protein Information
gamma-glutamylcyclotransferase; cytochrome c-releasing factor 21; gamma -glutamyl cyclotransferase

NCBI Summary for GGCT

The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
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UniProt Comments for GGCT

GGCT: Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Belongs to the gamma-glutamylcyclotransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Other Amino Acids Metabolism - glutathione; Transferase; EC 2.3.2.4

Chromosomal Location of Human Ortholog: 7p15-p14

Cellular Component: cytosol

Molecular Function: gamma-glutamylcyclotransferase activity; protein homodimerization activity

Biological Process: release of cytochrome c from mitochondria; xenobiotic metabolic process; glutathione biosynthetic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GGCT antibody

 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway antibodies  Defective AHCY Causes Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency (HMAHCHD) Pathway Diagram
 Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway antibodies  Defective GCLC Causes Hemolytic Anemia Due To Gamma-glutamylcysteine Synthetase Deficiency (HAGGSD) Pathway Diagram
 Defective GGT1 Causes Glutathionuria (GLUTH) Pathway antibodies  Defective GGT1 Causes Glutathionuria (GLUTH) Pathway Diagram
 Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway antibodies  Defective GSS Causes Glutathione Synthetase Deficiency (GSS Deficiency) Pathway Diagram
 Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway antibodies  Defective MAT1A Causes Methionine Adenosyltransferase Deficiency (MATD) Pathway Diagram
 Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway antibodies  Defective OPLAH Causes 5-oxoprolinase Deficiency (OPLAHD) Pathway Diagram
 Defective SLC35D1 Causes Schneckenbecken Dysplasia (SCHBCKD) Pathway antibodies  Defective SLC35D1 Causes Schneckenbecken Dysplasia (SCHBCKD) Pathway Diagram
 Defective TPMT Causes Thiopurine S-methyltransferase Deficiency (TPMT Deficiency) Pathway antibodies  Defective TPMT Causes Thiopurine S-methyltransferase Deficiency (TPMT Deficiency) Pathway Diagram
 Defective UGT1A1 Causes Hyperbilirubinemia Pathway antibodies  Defective UGT1A1 Causes Hyperbilirubinemia Pathway Diagram
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