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PELI2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248674

MBS248674 is an antibody targeting PELI2. Also known as Rabbit Polyclonal to Human PELI2 / Pellino 2. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PELI2 / Pellino 2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human PELI2 / Pellino 2
Product Gene Name
anti-PELI2 antibody
Product Synonym Names
Anti-PELI2 / Pellino 2 Antibody (aa22-51) IHC-plus; PELI2; Pellino homolog 2 (Drosophila); Protein pellino homolog 2; Pellino (Drosophila) homolog 2; Pellino 2; Pellino homolog 2; Pellino-2; Human PELI2; Pellino 2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity Purified
Specificity
Human PELI2 / Pellino 2
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
46,435 Da
OMIM
614798
3D Structure
ModBase 3D Structure for Q9HAT8
Target Species
Human
Immunogen Description
KLH-conjugated synthetic peptide from N-terminal region of human PELI2.
Immunogen Type
Synthetic peptide
Immunogen
PELI2 / Pellino 2 antibody was raised against kLH-conjugated synthetic peptide from N-terminal region of human PELI2.
Antigen Modification
aa22-51
Applications Tested/Suitable for anti-PELI2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-PELI2 antibody
IHC-P (1:100), WB (1:1000)

Immunohistochemistry (IHC) of anti-PELI2 antibody

Anti-PELI2 / Pellino 2 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Rabbit Anti-PELI2 Polyclonal Antibody – Cat# MBS248674

Western Blot (WB) of anti-PELI2 antibody

PELI2 Antibody (N-term) Western blot of 293 cell line lysates (35 ug/lane). This demonstrates the PELI2 antibody detected the PELI2 protein (arrow).
Rabbit Anti-PELI2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248674

Other Notes

Small volumes of anti-PELI2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PELI2. It may not necessarily be applicable to this product.

NCBI GI #
10864063
NCBI GeneID
57161
NCBI Accession #
NP_067078.1
UniProt Primary Accession #
Q9HAT8
UniProt Secondary Accession #
B2RDY5
UniProt Related Accession #
Q9HAT8
GenBank Nucleotide #
NM_021255.2
NCBI Official Full Name
E3 ubiquitin-protein ligase pellino homolog 2
NCBI Official Synonym Full Names
pellino E3 ubiquitin protein ligase family member 2
NCBI Official Symbol
PELI2
UniProt Protein Name
E3 ubiquitin-protein ligase pellino homolog 2
Protein Family
E3 ubiquitin-protein ligase
UniProt Gene Name
PELI2
UniProt Synonym Gene Names
Pellino-2
UniProt Entry Name
PELI2_HUMAN
NCBI Protein Information
E3 ubiquitin-protein ligase pellino homolog 2; pellino-2; protein pellino homolog 2

UniProt Comments for PELI2

PELI2: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Not required for NF-kappa-B activation. Belongs to the pellino family.

Protein type: EC 6.3.2.-; Adaptor/scaffold; Ubiquitin conjugating system; EC 6.3.2.19; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 14q21

Cellular Component: cytosol

Molecular Function: protein binding; ligase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; protein ubiquitination; Toll signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of MAPKKK cascade; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; positive regulation of protein amino acid phosphorylation; toll-like receptor 4 signaling pathway
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Research Articles on PELI2

1. A high-affinity Pellino2 e3 ubiquitin ligase binding domain is specific for phosphothreonine motifs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PELI2 antibody

 Reference Product  PubMed Publications
 PELI1 antibody  >5 publications with PELI2 and PELI1
 IRAK1 antibody  >4 publications with PELI2 and IRAK1
 PELI3 antibody  >2 publications with PELI2 and PELI3
 TRAF6 antibody  >1 publications with PELI2 and TRAF6
 MYD88 antibody  >1 publications with PELI2 and MYD88
 IRAK4 antibody  >1 publications with PELI2 and IRAK4

Pathways associated with anti-PELI2 antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IRAK1 Recruits IKK Complex Pathway antibodies  IRAK1 Recruits IKK Complex Pathway Diagram
 IRAK1 Recruits IKK Complex Upon TLR7/8 Or 9 Stimulation Pathway antibodies  IRAK1 Recruits IKK Complex Upon TLR7/8 Or 9 Stimulation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Interleukin-1 Signaling Pathway antibodies  Interleukin-1 Signaling Pathway Diagram
 MyD88 Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88 Cascade Initiated On Plasma Membrane Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram
 MyD88:Mal Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88:Mal Cascade Initiated On Plasma Membrane Pathway Diagram

Diseases associated with anti-PELI2 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1 publications with PELI2 and Necrosis

Organs/Tissues associated with anti-PELI2 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >2 publications with PELI2 and Bone Marrow
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