• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

MICU1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248730

MBS248730 is an antibody targeting MICU1. Also known as Goat Polyclonal to Human MICU1 / CBARA1. Reactive in Bat, Gibbon, Bovine, Chicken, Dog, Xenopus, Gorilla, Goat, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Zebrafish. Host: Goat. More details

$680 / 0.05 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MICU1 / CBARA1, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human MICU1 / CBARA1
Product Gene Name
anti-MICU1 antibody
Product Synonym Gene Name
CBARA1
Product Synonym Names
Anti-MICU1 / CBARA1 Antibody (Internal) IHC-plus; MICU1; Ara CALC; CBARA1; CALC; EFHA3; Mitochondrial calcium uptake 1; Allergen Hom s 4; Atopy related autoantigen; Atopy-related autoantigen CALC; Human MICU1; CBARA1
Clonality
Polyclonal
Host
Goat
Species Reactivity
Bat, Gibbon, Bovine, Chicken, Dog, Xenopus, Gorilla, Goat, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Zebrafish
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human CBARA1. This antibody is expected to recognize reported isoforms 1 and 2 (NP_006068.2; NP_001182447.1).
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
31,931 Da
OMIM
gene 615673
3D Structure
ModBase 3D Structure for Q9BPX6
Target Species
Human
Immunogen Description
Synthetic peptide C-EYENRIRAYSTPDK from an internal region of human CBARA1 (NP_006068.2; NP_001182447.1).
Immunogen Type
Synthetic peptide
Immunogen
MICU1 / CBARA1 antibody was raised against synthetic peptide C-EYENRIRAYSTPDK from an internal region of human CBARA1 (NP_006068.2; NP_001182447.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Goat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Lizard, Xenopus, Stickleback, Pufferfish, Zebrafish, Seq squirt, Ant (100%); Blood fluke, Mosquito, Sea anemone, Water flea, Beetle, Tick (93%); Drosophila (86%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-MICU1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-MICU1 antibody
ELISA (1:32000), IHC-P (3.75 ug/ml), WB (0.5 - 2 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:32000. Western blot: Approx 55kD band observed in lysates of cell line K562 (calculated MW of 54.6kD according to NP_006068.2). Recommended concentration: 0.5-2 ug/ml. An additional band of unknown i...

Immunohistochemistry (IHC) of anti-MICU1 antibody

Anti-MICU1 / CBARA1 antibody IHC staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Goat Anti-MICU1 Polyclonal Antibody – Cat# MBS248730

Western Blot (WB) of anti-MICU1 antibody

CBARA1 antibody (0.5 ug/ml) staining of K562 lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-MICU1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248730

Other Notes

Small volumes of anti-MICU1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MICU1. It may not necessarily be applicable to this product.

NCBI GI #
116256483
NCBI GeneID
10367
NCBI Accession #
NP_006068.2
UniProt Primary Accession #
Q9BPX6
UniProt Secondary Accession #
O75785; Q9H9N6; Q9UFX0; A8MV96; B3KN20; B4DJH9; B4DPI1; B5MBY3; D3YTJ3
UniProt Related Accession #
Q9BPX6
GenBank Nucleotide #
NM_006077.3
NCBI Official Full Name
calcium uptake protein 1, mitochondrial isoform 1
NCBI Official Synonym Full Names
mitochondrial calcium uptake 1
NCBI Official Symbol
MICU1
NCBI Official Synonym Symbols
CALC; EFHA3; MPXPS; CBARA1
UniProt Protein Name
Calcium uptake protein 1, mitochondrial
UniProt Synonym Protein Names
Atopy-related autoantigen CALC; ara CALC; Calcium-binding atopy-related autoantigen 1; Allergen: Hom s 4
Protein Family
Calcium uptake protein
UniProt Gene Name
MICU1
UniProt Synonym Gene Names
CALC; CBARA1; ara CALC
UniProt Entry Name
MICU1_HUMAN
NCBI Protein Information
calcium uptake protein 1, mitochondrial; ara CALC; atopy-related autoantigen CALC; calcium-binding atopy-related autoantigen 1

NCBI Summary for MICU1

This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013]
Show more

UniProt Comments for MICU1

MICU1: Key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. May act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG. Belongs to the MICU1 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Mitochondrial; Calcium-binding

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: mitochondrion; mitochondrial inner membrane; mitochondrial intermembrane space; intracellular

Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; calcium ion binding

Biological Process: mitochondrial calcium ion homeostasis; defense response; mitochondrial calcium ion transport; protein homooligomerization; elevation of mitochondrial calcium ion concentration

Disease: Myopathy With Extrapyramidal Signs
Show more

Research Articles on MICU1

1. Expression of MICU1 mutants lacking functional Ca2+-binding sites leads to a striking loss of Ca2+ uptake in HEK293 cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MICU1 antibody

 Reference Product  PubMed Publications
 LETM1 antibody  >8 publications with MICU1 and LETM1
 CCDC109A antibody  >2 publications with MICU1 and CCDC109A

Diseases associated with anti-MICU1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with MICU1 and Inflammation
 Immune System Diseases Antibodies  >2 publications with MICU1 and Immune System Diseases
 Heart Diseases Antibodies  >2 publications with MICU1 and Heart Diseases
 Movement Disorders Antibodies  >2 publications with MICU1 and Movement Disorders
 Carcinoma, Hepatocellular Antibodies  >1 publications with MICU1 and Carcinoma, Hepatocellular
 Muscular Diseases Antibodies  >1 publications with MICU1 and Muscular Diseases
 Learning Disorders Antibodies  >1 publications with MICU1 and Learning Disorders

Organs/Tissues associated with anti-MICU1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with MICU1 and Blood
 Liver Antibodies  >3 publications with MICU1 and Liver
 Heart Antibodies  >3 publications with MICU1 and Heart
 Pancreas Antibodies  >2 publications with MICU1 and Pancreas
 Muscle Antibodies  >2 publications with MICU1 and Muscle
 Skin Antibodies  >2 publications with MICU1 and Skin
 Brain Antibodies  >2 publications with MICU1 and Brain
 Embryonic Tissue Antibodies  >1 publications with MICU1 and Embryonic Tissue
 Vascular Antibodies  >1 publications with MICU1 and Vascular
 Lung Antibodies  >1 publications with MICU1 and Lung
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000