Rabbit Anti-GALR1 Polyclonal Antibody – Cat# MBS248743

Anti-GALR1 / Galanin Receptor 1 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GALR1 Antibody – Rabbit Polyclonal

Name: GALR1 Antibody; Polyclonal; Rabbit; Chicken/Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS248743
Price: 740 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248743

GalR1 is a Galanin Receptor that mediates the effects of the peptide galanin in a wide variety of tissues. Unlike GalR2, the primary signaling mechanism of GalR1 is by inhibiting adenylate cyclase through Gi. GalR1 regulates the GnRH neuroendocrine axis with… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

GALR1 / Galanin Receptor 1, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal (IgG) to Human GALR1 / Galanin Receptor 1

Product Gene Name

anti-GALR1 antibody

Product Synonym Names

Anti-GALR1 / Galanin Receptor 1 Antibody (C-Terminus) IHC-plus; GALR1; Galanin receptor type 1; Galanin receptor 1; Galanin receptor galr1; Galanin-1 receptor; GALNR1; Gal receptor 1; Gal-r1; Galn1r; Gal-1 receptor; GAL1-R; Galanin r1 receptor; GALNR; GALR-1; Hugal 1-r; Human GALR1; Galanin Receptor 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Chicken, Human

Form/Format

0.1 M Tris-glycine, pH 7, 10% Glycerol, 0.01% Thimerosal

Purity/Purification

Immunoaffinity Purified

Concentration

0.3 mg/ml (lot specific)

Specificity

Human GALR1

Preparation and Storage

Aliquot and freeze at -20 degree C. Avoid freeze-thaw cycles.

Molecular Weight

38,953 Da

OMIM

600377

3D Structure

ModBase 3D Structure for P47211

Target Species

Human

Immunogen Description

Synthetic peptide corresponding to a region within amino acids 285 and 349 of galanin receptor 1 (SwissProt P47211). Percent identity by BLAST analysis: Human, Chicken (100%).

Immunogen Type

Synthetic peptide

Immunogen

GALR1 / Galanin Receptor 1 antibody was raised against synthetic peptide corresponding to a region within amino acids 285 and 349 of galanin receptor 1 (SwissProt P47211). Percent identity by BLAST analysis: Human, Chicken (100%).

Antigen Modification

C-Terminus

Product Categories/Family for anti-GALR1 antibody

Family: GPCR; Subfamily: Galanin

Applications Tested/Suitable for anti-GALR1 antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-GALR1 antibody

ELISA, IHC-P (10 ug/ml)
Usage: Antibody reactive against peptide, detects immunogen.

Other Notes

Small volumes of anti-GALR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GALR1 purchase

MBS248743 is an antibody targeting GALR1. Also known as Rabbit Polyclonal (IgG) to Human GALR1 / Galanin Receptor 1. Reactive in Chicken, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GALR1. It may not necessarily be applicable to this product.

NCBI GI #

167000885

NCBI GeneID

2587

NCBI Accession #

NP_001471.2

UniProt Primary Accession #

P47211

UniProt Secondary Accession #

Q4VBL7

UniProt Related Accession #

P47211

GenBank Nucleotide #

NM_001480.3

NCBI Official Full Name

galanin receptor type 1

NCBI Official Synonym Full Names

galanin receptor 1

NCBI Official Symbol

GALR1

NCBI Official Synonym Symbols

GALNR; GALNR1

UniProt Protein Name

Galanin receptor type 1

Protein Family

Galanin receptor

UniProt Gene Name

GALR1

UniProt Synonym Gene Names

GALNR; GALNR1; GAL1-R; GALR-1

UniProt Entry Name

GALR1_HUMAN

NCBI Protein Information

galanin receptor type 1; GAL1-R; GALR-1

NCBI Summary for GALR1

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]

UniProt Comments for GALR1

GALR1: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 18q23

Cellular Component: plasma membrane; integral to membrane

Molecular Function: neuropeptide binding; protein binding; peptide hormone binding; galanin receptor activity

Biological Process: positive regulation of cortisol secretion; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; negative regulation of adenylate cyclase activity; digestion; positive regulation of transcription from RNA polymerase II promoter; G-protein signaling, adenylate cyclase activating pathway

Research Articles on GALR1

1. Variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GALR1 antibody

Reference Product	PubMed Publications
GALR2 antibody	>153 publications with GALR1 and GALR2
GALR3 antibody	>79 publications with GALR1 and GALR3
GAL antibody	>53 publications with GALR1 and GAL
NPY antibody	>4 publications with GALR1 and NPY
POMC antibody	>3 publications with GALR1 and POMC
NPY1R antibody	>1 publications with GALR1 and NPY1R

Pathways associated with anti-GALR1 antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies	Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-GALR1 antibody

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>11 publications with GALR1 and Disease Models, Animal
Inflammation Antibodies	>8 publications with GALR1 and Inflammation
Necrosis Antibodies	>4 publications with GALR1 and Necrosis
Learning Disorders Antibodies	>4 publications with GALR1 and Learning Disorders
Memory Disorders Antibodies	>3 publications with GALR1 and Memory Disorders
Adenoma Antibodies	>3 publications with GALR1 and Adenoma
Weight Loss Antibodies	>2 publications with GALR1 and Weight Loss
Fetal Growth Retardation Antibodies	>1 publications with GALR1 and Fetal Growth Retardation
Hyperglycemia Antibodies	>1 publications with GALR1 and Hyperglycemia
Immune System Diseases Antibodies	>1 publications with GALR1 and Immune System Diseases

Organs/Tissues associated with anti-GALR1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>114 publications with GALR1 and Brain
Nerve Antibodies	>35 publications with GALR1 and Nerve
Prostate Antibodies	>2 publications with GALR1 and Prostate