BRN2 Antibody – Rabbit Polyclonal

This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]

Oct7: Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters. Interacts with PQBP1. Expressed specifically in the neuroectodermal cell lineage. Belongs to the POU transcription factor family. Class- 3 subfamily. 3 isoforms of the human protein are produced by alternative initiation.

Protein type: DNA-binding; Transcription factor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6q16

Cellular Component: transcription factor complex; nucleus

Molecular Function: identical protein binding; protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: epidermis development; transcription, DNA-dependent; positive regulation of multicellular organism growth; hypothalamus cell differentiation; regulation of axonogenesis; astrocyte development; myelination in the peripheral nervous system; neuron differentiation; neurohypophysis development; positive regulation of cell proliferation; cerebral cortex radially oriented cell migration; positive regulation of transcription from RNA polymerase II promoter; forebrain ventricular zone progenitor cell division