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HEXIM1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248799

MBS248799 is an antibody targeting HEXIM1. Also known as Rabbit Polyclonal to Human HEXIM1. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
HEXIM1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human HEXIM1
Product Gene Name
anti-HEXIM1 antibody
Product Synonym Names
Anti-HEXIM1 Antibody (aa201-230) IHC-plus; HEXIM1; Cardiac lineage protein 1; CLP-1; EDG1; HMBA-inducible; Menage a quatre 1; Menage a quatre protein 1; Protein HEXIM1; MAQ1; HIS1; Human HEXIM1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity Purified
Specificity
Human HEXIM1
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
40,623 Da
OMIM
607328
3D Structure
ModBase 3D Structure for O94992
Target Species
Human
Immunogen Description
KLH-conjugated synthetic peptide from internal region of human HEXIM1.
Immunogen Type
Synthetic peptide
Immunogen
HEXIM1 antibody was raised against kLH-conjugated synthetic peptide from internal region of human HEXIM1.
Antigen Modification
aa201-230
Applications Tested/Suitable for anti-HEXIM1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-HEXIM1 antibody
IHC-P (1:10 - 1:100), WB (1:1000)

Immunohistochemistry (IHC) of anti-HEXIM1 antibody

Anti-HEXIM1 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-HEXIM1 Polyclonal Antibody – Cat# MBS248799

Western Blot (WB) of anti-HEXIM1 antibody

HEXIM1 antibody (Center) Western blot of mouse liver tissue lysates (35 ug/lane). This demonstrates the HEXIM1 antibody detected the HEXIM1 protein (arrow).
Rabbit Anti-HEXIM1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248799

Other Notes

Small volumes of anti-HEXIM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for HEXIM1. It may not necessarily be applicable to this product.

NCBI GI #
5453682
NCBI GeneID
10614
NCBI Accession #
NP_006451.1
UniProt Primary Accession #
O94992
UniProt Secondary Accession #
B2R8Y5
UniProt Related Accession #
O94992
GenBank Nucleotide #
NM_006460.2
NCBI Official Full Name
protein HEXIM1
NCBI Official Synonym Full Names
hexamethylene bis-acetamide inducible 1
NCBI Official Symbol
HEXIM1
NCBI Official Synonym Symbols
CLP1; EDG1; HIS1; MAQ1
UniProt Protein Name
Protein HEXIM1
UniProt Synonym Protein Names
Cardiac lineage protein 1; Estrogen down-regulated gene 1 protein; Hexamethylene bis-acetamide-inducible protein 1; Menage a quatre protein 1
Protein Family
Protein
UniProt Gene Name
HEXIM1
UniProt Synonym Gene Names
CLP1; EDG1; HIS1; MAQ1
UniProt Entry Name
HEXI1_HUMAN
NCBI Protein Information
protein HEXIM1; HMBA-inducible; menage a quatre 1; cardiac lineage protein 1; menage a quatre protein 1; estrogen down-regulated gene 1 protein; hexamthylene bis-acetamide inducible 1; hexamethylene bisacetamide-inducible protein; hexamethylene bis-acetamide-inducible protein 1; hexamethylene-bis-acetamide-inducible transcript 1

NCBI Summary for HEXIM1

Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]

UniProt Comments for HEXIM1

HEXIM1: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with the N-CoR complex through NCOR1. Interacts with ESR1 and NR3C1. May interact with NF-kappa-B through RELA. Up-regulated by HMBA (hexamethylene bisacetamide). Down-regulated by estrogen. Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. Belongs to the HEXIM family.

Protein type: Transcription factor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; snRNA binding

Biological Process: transcription, DNA-dependent; heart development; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
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Research Articles on HEXIM1

1. HEXIM1 functions as an AR (androgen receptor) co-repressor as it physically interacts with the AR and is required for the ability of anti-androgens to inhibit androgen-induced target gene expression and cell proliferation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HEXIM1 antibody

 Reference Product  PubMed Publications
 CDK9 antibody  >51 publications with HEXIM1 and CDK9
 CCNT1 antibody  >21 publications with HEXIM1 and CCNT1
 BRD4 antibody  >14 publications with HEXIM1 and BRD4
 LARP7 antibody  >10 publications with HEXIM1 and LARP7
 MEPCE antibody  >4 publications with HEXIM1 and MEPCE
 CCNT2 antibody  >4 publications with HEXIM1 and CCNT2
 MDM2 antibody  >2 publications with HEXIM1 and MDM2
 AKT1 antibody  >1 publications with HEXIM1 and AKT1

Diseases associated with anti-HEXIM1 antibody

 Disease Name  Pubmed Publications
 Hypertrophy Antibodies  >17 publications with HEXIM1 and Hypertrophy
 Heart Diseases Antibodies  >13 publications with HEXIM1 and Heart Diseases
 Disease Models, Animal Antibodies  >5 publications with HEXIM1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >3 publications with HEXIM1 and Nervous System Diseases
 Inflammation Antibodies  >3 publications with HEXIM1 and Inflammation
 Fibrosis Antibodies  >2 publications with HEXIM1 and Fibrosis
 Lung Diseases Antibodies  >2 publications with HEXIM1 and Lung Diseases
 Necrosis Antibodies  >2 publications with HEXIM1 and Necrosis
 Atherosclerosis Antibodies  >1 publications with HEXIM1 and Atherosclerosis
 Hyperplasia Antibodies  >1 publications with HEXIM1 and Hyperplasia

Organs/Tissues associated with anti-HEXIM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Mammary Gland Antibodies  >3 publications with HEXIM1 and Mammary Gland
 Pancreas Antibodies  >1 publications with HEXIM1 and Pancreas
 Thymus Antibodies  >1 publications with HEXIM1 and Thymus
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