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GNA12 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248816

MBS248816 is an antibody targeting GNA12. Also known as Rabbit Polyclonal to Human GNA12. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GNA12, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human GNA12
Product Gene Name
anti-GNA12 antibody
Product Synonym Names
Anti-GNA12 Antibody (Ser67) IHC-plus; GNA12; G-protein subunit alpha-12; G alpha-12; GEP; NNX3; RMP; WUGSC:H_GS165O14.2; Human GNA12
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS with 0.09% (w/v) sodium azide
Purity/Purification
Immunoaffinity Purified
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
34,002 Da
OMIM
604394
3D Structure
ModBase 3D Structure for Q03113
Target Species
Human
Immunogen Description
KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S67 of human GNA12.
Immunogen Type
Synthetic peptide
Immunogen
GNA12 antibody was raised against kLH conjugated synthetic peptide corresponding to amino acid residues surrounding S67 of human GNA12.
Antigen Modification
Ser67
Applications Tested/Suitable for anti-GNA12 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-GNA12 antibody
IHC-P (10 ug/ml), WB (1:1000)

Immunohistochemistry (IHC) of anti-GNA12 antibody

Anti-GNA12 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GNA12 Polyclonal Antibody – Cat# MBS248816

Western Blot (WB) of anti-GNA12 antibody

Western blot of anti-GNA12 Antibody (S67) in A2058 cell line lysates (35 ug/lane). GNA12(arrow) was detected using the purified Pab.
Rabbit Anti-GNA12 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248816

Other Notes

Small volumes of anti-GNA12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GNA12. It may not necessarily be applicable to this product.

NCBI GI #
42476111
NCBI GeneID
2768
NCBI Accession #
NP_031379.2
UniProt Primary Accession #
Q03113
UniProt Secondary Accession #
Q2T9L1; Q5PPR5; Q86UM8; Q8TD71; Q9UDU9; A4D204; B3KXS2; B7Z3F7
UniProt Related Accession #
Q03113
GenBank Nucleotide #
NM_007353.2
NCBI Official Full Name
guanine nucleotide-binding protein subunit alpha-12 isoform 1
NCBI Official Synonym Full Names
guanine nucleotide binding protein (G protein) alpha 12
NCBI Official Symbol
GNA12
NCBI Official Synonym Symbols
RMP; gep; NNX3
UniProt Protein Name
Guanine nucleotide-binding protein subunit alpha-12
Protein Family
Guanine nucleotide-binding protein
UniProt Gene Name
GNA12
UniProt Synonym Gene Names
G alpha-12; G-protein subunit alpha-12
UniProt Entry Name
GNA12_HUMAN
NCBI Protein Information
guanine nucleotide-binding protein subunit alpha-12; g alpha-12; WUGSC:H_GS165O14.2; G-protein subunit alpha-12

UniProt Comments for GNA12

G-alpha 12: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Belongs to the G-alpha family. G(12) subfamily.

Protein type: G protein, heterotrimeric; G protein; G protein, heterotrimeric alpha G(12)

Chromosomal Location of Human Ortholog: 7p22.2

Cellular Component: focal adhesion; brush border membrane; plasma membrane; heterotrimeric G-protein complex

Molecular Function: GTPase activity; protein binding; signal transducer activity; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; D5 dopamine receptor binding

Biological Process: response to drug; platelet activation; metabolic process; in utero embryonic development; regulation of proteasomal ubiquitin-dependent protein catabolic process; Rho protein signal transduction; regulation of TOR signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; regulation of cell shape; embryonic digit morphogenesis; cell differentiation; blood coagulation
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Research Articles on GNA12

1. CREB is a critical signaling node in Lysophosphatidic acid-Lysophosphatidic acid receptor and Galpha12/gep proto-oncogene stimulated oncogenic signaling in ovarian cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GNA12 antibody

 Reference Product  PubMed Publications
 GNA13 antibody  >4 publications with GNA12 and GNA13

Pathways associated with anti-GNA12 antibody

 Products by Pathway  Pathway Diagram
 Endothelins Pathway antibodies  Endothelins Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 LPA Receptor Mediated Events Pathway antibodies  LPA Receptor Mediated Events Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 Long-term Depression Pathway antibodies  Long-term Depression Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram

Diseases associated with anti-GNA12 antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >2 publications with GNA12 and Hypertension
 Colitis, Ulcerative Antibodies  >2 publications with GNA12 and Colitis, Ulcerative
 Depressive Disorder Antibodies  >1 publications with GNA12 and Depressive Disorder
 Heart Diseases Antibodies  >1 publications with GNA12 and Heart Diseases
 Hyperplasia Antibodies  >1 publications with GNA12 and Hyperplasia

Organs/Tissues associated with anti-GNA12 antibody

 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >2 publications with GNA12 and Placenta
 Blood Antibodies  >2 publications with GNA12 and Blood
 Embryonic Tissue Antibodies  >1 publications with GNA12 and Embryonic Tissue
 Connective Tissue Antibodies  >1 publications with GNA12 and Connective Tissue
 Prostate Antibodies  >1 publications with GNA12 and Prostate
 Mouth Antibodies  >1 publications with GNA12 and Mouth
 Vascular Antibodies  >1 publications with GNA12 and Vascular
 Uterus Antibodies  >1 publications with GNA12 and Uterus
 Lung Antibodies  >1 publications with GNA12 and Lung
 Heart Antibodies  >1 publications with GNA12 and Heart
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