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PTPLA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248837

PTPLA, a PTP-like protein phosphatase, has been suggested to affect muscle development and cardiac differentiation. PTPLA contains proline instead of arginine in the catalytic domain and may represent a new class of protein phosphatase. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PTPLA, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human PTPLA
Product Gene Name
anti-PTPLA antibody
Product Synonym Names
Anti-PTPLA Antibody (aa36-66) IHC-plus; PTPLA; CAP; Cementum attachment protein; HACD1; Human PTPLA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.09% sodium azide
Purity/Purification
Immunoaffinity Purified
Specificity
Human PTPLA
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
14,920 Da
3D Structure
ModBase 3D Structure for B0YJ81
Target Species
Human
Immunogen Description
KLH-conjugated synthetic peptide from N-terminal region of human PTPLA.
Immunogen Type
Synthetic peptide
Antigen Modification
aa36-66

Product Categories/Family for anti-PTPLA antibody

Family: Protein Phosphatase; Subfamily: PTP-like
Applications Tested/Suitable for anti-PTPLA antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-PTPLA antibody
IHC-P (1:100), WB (1:1000)

Immunohistochemistry (IHC) of anti-PTPLA antibody

Anti-PTPLA antibody IHC staining of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Rabbit Anti-PTPLA Polyclonal Antibody – Cat# MBS248837

Immunohistochemistry (IHC) of anti-PTPLA antibody

Anti-PTPLA antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-PTPLA Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS248837

Western Blot (WB) of anti-PTPLA antibody

PTPLA Antibody (N-term) Western blot of MDA-MB231 cell line lysates (35 ug/lane). This demonstrates the PTPLA antibody detected the PTPLA protein (arrow).
Rabbit Anti-PTPLA Polyclonal Antibody, Western Blot (WB) – Cat# MBS248837

Other Notes

Small volumes of anti-PTPLA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTPLA purchase

MBS248837 is an antibody targeting PTPLA. Also known as Rabbit Polyclonal to Human PTPLA. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTPLA. It may not necessarily be applicable to this product.

NCBI GI #
82659105
NCBI GeneID
9200
NCBI Accession #
NP_055056.3
UniProt Primary Accession #
B0YJ81
UniProt Secondary Accession #
Q6JIC5; Q96FW7; Q9HB93; Q9UHX2; B0YJ80
UniProt Related Accession #
B0YJ81
GenBank Nucleotide #
NM_014241.3
NCBI Official Full Name
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1
NCBI Official Synonym Full Names
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
NCBI Official Symbol
PTPLA
NCBI Official Synonym Symbols
CAP; HACD1
UniProt Protein Name
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1
UniProt Synonym Protein Names
3-hydroxyacyl-CoA dehydratase 1; HACD1; Cementum attachment protein; Protein-tyrosine phosphatase-like member A
UniProt Gene Name
PTPLA
UniProt Synonym Gene Names
HACD1; HACD1
UniProt Entry Name
HACD1_HUMAN
NCBI Protein Information
very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1; cementum attachment protein; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1

NCBI Summary for PTPLA

The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation. [provided by RefSeq, Jul 2008]
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UniProt Comments for PTPLA

PTPLA: Responsible for the dehydration step in very long-chain fatty acids (VLCFAs) synthesis. Belongs to the very long-chain fatty acids dehydratase HACD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Motility/polarity/chemotaxis; EC 4.2.1.134; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10p12.33

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: enzyme binding; hydroxyapatite binding; lyase activity; 3-hydroxyacyl-CoA dehydratase activity

Biological Process: sphingolipid biosynthetic process; multicellular organismal development; regulation of G2/M transition of mitotic cell cycle; very-long-chain fatty acid biosynthetic process; myotube differentiation; fatty acid elongation; fatty acid biosynthetic process
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Research Articles on PTPLA

1. These data indicate that HACD1 is necessary for muscle function.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTPLA antibody

 Reference Product  PubMed Publications
 CEMP1 antibody  >6 publications with PTPLA and CEMP1
 IBSP antibody  >1 publications with PTPLA and IBSP
 MTM1 antibody  >1 publications with PTPLA and MTM1

Pathways associated with anti-PTPLA antibody

 Products by Pathway  Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway antibodies  Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway Diagram
 Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway antibodies  Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway Diagram
 Fatty Acid Elongation Pathway antibodies  Fatty Acid Elongation Pathway Diagram
 Fatty Acid Elongation Pathway antibodies  Fatty Acid Elongation Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram

Diseases associated with anti-PTPLA antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with PTPLA and Nervous System Diseases
 Muscular Diseases Antibodies  >5 publications with PTPLA and Muscular Diseases
 Heart Diseases Antibodies  >4 publications with PTPLA and Heart Diseases
 Cardiomyopathies Antibodies  >3 publications with PTPLA and Cardiomyopathies
 Abnormalities, Multiple Antibodies  >1 publications with PTPLA and Abnormalities, Multiple
 Necrosis Antibodies  >1 publications with PTPLA and Necrosis

Organs/Tissues associated with anti-PTPLA antibody

 Organ/Tissue Name  Pubmed Publications
 Mouth Antibodies  >8 publications with PTPLA and Mouth
 Muscle Antibodies  >8 publications with PTPLA and Muscle
 Heart Antibodies  >6 publications with PTPLA and Heart
 Liver Antibodies  >3 publications with PTPLA and Liver
 Embryonic Tissue Antibodies  >2 publications with PTPLA and Embryonic Tissue
 Prostate Antibodies  >1 publications with PTPLA and Prostate
 Connective Tissue Antibodies  >1 publications with PTPLA and Connective Tissue
 Testis Antibodies  >1 publications with PTPLA and Testis
 Skin Antibodies  >1 publications with PTPLA and Skin
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