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IST1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248878

MBS248878 is an antibody targeting IST1. Also known as Rabbit Polyclonal (IgG) to Human IST1. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IST1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human IST1
Product Gene Name
anti-IST1 antibody
Product Synonym Names
Anti-IST1 Antibody IHC-plus; IST1; CRS1; HIST1; IST1 homolog; KIAA0174; OLC1; Increased sodium tolerance-1; SCS; Overexpressed in lung cancer 1; TWACS3; Human IST1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, pH 7, 40% Glycerol, 0.01% Thimerosal
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human IST1
Preparation and Storage
Aliquot and freeze at -20 degree C. Avoid freeze-thaw cycles.
Molecular Weight
23,089 Da
3D Structure
ModBase 3D Structure for P53990
Target Species
Human
Immunogen Description
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 125 and 317 of Human KIAA0174. Percent identity by BLAST analysis: Human (100%).
Immunogen Type
Recombinant protein
Immunogen
IST1 antibody was raised against recombinant protein fragment contain a sequence corresponding to a region within amino acids 125 and 317 of Human KIAA0174. Percent identity by BLAST analysis: Human (100%).
Applications Tested/Suitable for anti-IST1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-IST1 antibody
IHC-P (10 ug/ml), WB
Usage: Tested in Western blot with recombinant protein, not yet shown to detect endogenous KIAA0174.

Immunohistochemistry (IHC) of anti-IST1 antibody

Anti-IST1 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-IST1 Polyclonal Antibody – Cat# MBS248878

Other Notes

Small volumes of anti-IST1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IST1. It may not necessarily be applicable to this product.

NCBI GI #
41281489
NCBI GeneID
9798
NCBI Accession #
NP_055576.2
UniProt Primary Accession #
P53990
UniProt Secondary Accession #
Q3SYM4; Q9BQ81; Q9BWN2; A8KAH5; J3QLU7
UniProt Related Accession #
P53990
GenBank Nucleotide #
NM_014761.3
NCBI Official Full Name
IST1 homolog isoform b
NCBI Official Synonym Full Names
increased sodium tolerance 1 homolog (yeast)
NCBI Official Symbol
IST1
NCBI Official Synonym Symbols
OLC1
UniProt Protein Name
IST1 homolog
UniProt Synonym Protein Names
Putative MAPK-activating protein PM28
Protein Family
IST1
UniProt Gene Name
IST1
UniProt Synonym Gene Names
KIAA0174; hIST1
UniProt Entry Name
IST1_HUMAN
NCBI Protein Information
IST1 homolog; overexpressed in lung cancer 1; putative MAPK-activating protein PM28

NCBI Summary for IST1

This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
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UniProt Comments for IST1

IST1: Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. Belongs to the IST1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Cell cycle regulation

Chromosomal Location of Human Ortholog: 16q22.2

Cellular Component: centrosome; cytoplasmic membrane-bound vesicle; ER-Golgi intermediate compartment; midbody; cytosol

Molecular Function: protein domain specific binding; protein binding; protein complex binding

Biological Process: release of virus from host; protein localization; establishment of protein localization; cell division; positive regulation of proteolysis; abscission; cytokinesis; viral capsid re-envelopment; positive regulation of collateral sprouting
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Research Articles on IST1

1. Findings indicate that a high expression level of overexpressed in lung cancer 1 (OLC1) serves as a biomarker for poor prognosis for breast cancer, suggesting that OLC1 may be a potential target of antiangiogenic therapy for breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IST1 antibody

 Reference Product  PubMed Publications
 VTA1 antibody  >4 publications with IST1 and VTA1
 CHMP1A antibody  >3 publications with IST1 and CHMP1A
 VPS4A antibody  >2 publications with IST1 and VPS4A
 SPAST antibody  >1 publications with IST1 and SPAST
 CHMP2A antibody  >1 publications with IST1 and CHMP2A
 CHMP5 antibody  >1 publications with IST1 and CHMP5

Diseases associated with anti-IST1 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >1 publications with IST1 and Kidney Diseases

Organs/Tissues associated with anti-IST1 antibody

 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >1 publications with IST1 and Adipose Tissue
 Bone Antibodies  >1 publications with IST1 and Bone
 Blood Antibodies  >1 publications with IST1 and Blood
 Embryonic Tissue Antibodies  >1 publications with IST1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with IST1 and Kidney
 Uterus Antibodies  >1 publications with IST1 and Uterus
 Brain Antibodies  >1 publications with IST1 and Brain
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