• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ORC3L Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248895

MBS248895 is an antibody targeting ORC3L. Also known as Goat Polyclonal to Human ORC3L / ORC3. Reactive in Bat, Gibbon, Bovine, Chicken, Dog, Xenopus, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Zebrafish. Host: Goat. More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
ORC3L / ORC3, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human ORC3L / ORC3
Product Gene Name
anti-ORC3L antibody
Product Synonym Gene Name
ORC3
Product Synonym Names
Anti-ORC3L / ORC3 Antibody (C-Terminus) IHC-plus; ORC3; LATHEO; Homolog of latheo; Drosophila; ORC3L; IMAGE50150; Human ORC3L; ORC3
Clonality
Polyclonal
Host
Goat
Species Reactivity
Bat, Gibbon, Bovine, Chicken, Dog, Xenopus, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Zebrafish
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human ORC3 / ORC3L. This antibody is expected to recognize both reported isoforms (NP_862820.1 and NP_036513.2).
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
65,929 Da
OMIM
604972
3D Structure
ModBase 3D Structure for Q9UBD5
Target Species
Human
Immunogen Description
Synthetic peptide QKTDHVARLTWGGC from the C-terminus of human ORC3 / ORC3L (NP_862820.1; NP_036513.2).
Immunogen Type
Synthetic peptide
Immunogen
ORC3L / ORC3 antibody was raised against synthetic peptide QKTDHVARLTWGGC from the C-terminus of human ORC3 / ORC3L (NP_862820.1; NP_036513.2). Percent identity by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Platypus, Xenopus, Zebrafish (100%); Lizard, Salmon (93%); Sea anemone, Beetle (86%).
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-ORC3L antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-ORC3L antibody
ELISA (1:32000), IHC-P (3.75 ug/ml), WB (1 - 3 ug/ml)

Immunohistochemistry (IHC) of anti-ORC3L antibody

Human Brain, Cortex
Goat Anti-ORC3L Polyclonal Antibody – Cat# MBS248895

Western Blot (WB) of anti-ORC3L antibody

Antibody (2 ug/ml) staining of HeLa lysate (RIPA buffer, 1.4E5 cells per lane). Detected by Western blot of chemiluminescence.
Goat Anti-ORC3L Polyclonal Antibody, Western Blot (WB) – Cat# MBS248895

Other Notes

Small volumes of anti-ORC3L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ORC3L. It may not necessarily be applicable to this product.

NCBI GI #
32483367
NCBI GeneID
23595
NCBI Accession #
NP_036513.2
UniProt Primary Accession #
Q9UBD5
UniProt Secondary Accession #
Q13565; Q53GY6; Q5T159; Q6IUY7; Q86TN5; Q9UG44; Q9UNT6; A2A2T5; B4E025
UniProt Related Accession #
Q9UBD5
GenBank Nucleotide #
NM_012381.3
NCBI Official Full Name
origin recognition complex subunit 3 isoform 2
NCBI Official Synonym Full Names
origin recognition complex, subunit 3
NCBI Official Symbol
ORC3
NCBI Official Synonym Symbols
LAT; ORC3L; LATHEO
UniProt Protein Name
Origin recognition complex subunit 3
UniProt Synonym Protein Names
Origin recognition complex subunit Latheo
UniProt Gene Name
ORC3
UniProt Synonym Gene Names
LATHEO; ORC3L
UniProt Entry Name
ORC3_HUMAN
NCBI Protein Information
origin recognition complex subunit 3; homolog of latheo, Drosophila; origin recognition complex subunit Latheo; origin recognition complex, subunit 3 honolog

NCBI Summary for ORC3L

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for ORC3L

ORC3L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Belongs to the ORC3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 6q14.3-q16.1

Cellular Component: nucleoplasm; nuclear origin of replication recognition complex; origin recognition complex

Molecular Function: protein binding; DNA replication origin binding

Biological Process: mitotic cell cycle; DNA replication; G1/S transition of mitotic cell cycle
Show more

Research Articles on ORC3L

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ORC3L antibody

 Products by Pathway  Pathway Diagram
 Activation Of ATR In Response To Replication Stress Pathway antibodies  Activation Of ATR In Response To Replication Stress Pathway Diagram
 Activation Of The Pre-replicative Complex Pathway antibodies  Activation Of The Pre-replicative Complex Pathway Diagram
 Assembly Of The ORC Complex At The Origin Of Replication Pathway antibodies  Assembly Of The ORC Complex At The Origin Of Replication Pathway Diagram
 Assembly Of The Pre-replicative Complex Pathway antibodies  Assembly Of The Pre-replicative Complex Pathway Diagram
 Association Of Licensing Factors With The Pre-replicative Complex Pathway antibodies  Association Of Licensing Factors With The Pre-replicative Complex Pathway Diagram
 CDC6 Association With The ORC:origin Complex Pathway antibodies  CDC6 Association With The ORC:origin Complex Pathway Diagram
 CDT1 Association With The CDC6:ORC:origin Complex Pathway antibodies  CDT1 Association With The CDC6:ORC:origin Complex Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram

Organs/Tissues associated with anti-ORC3L antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with ORC3L and Brain
 Nerve Antibodies  >2 publications with ORC3L and Nerve
 Blood Antibodies  >2 publications with ORC3L and Blood
 Embryonic Tissue Antibodies  >2 publications with ORC3L and Embryonic Tissue
 Vascular Antibodies  >2 publications with ORC3L and Vascular
 Ovary Antibodies  >1 publications with ORC3L and Ovary
 Thymus Antibodies  >1 publications with ORC3L and Thymus
 Eye Antibodies  >1 publications with ORC3L and Eye
 Kidney Antibodies  >1 publications with ORC3L and Kidney
 Testis Antibodies  >1 publications with ORC3L and Testis
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000