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AP-1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248901

MBS248901 is an antibody targeting AP-1. Also known as Rabbit Polyclonal to Human AP-1 / JUND. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
AP-1 / JUND, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human AP-1 / JUND
Product Gene Name
anti-AP-1 antibody
Product Synonym Gene Name
JUND
Product Synonym Names
Anti-AP-1 / JUND Antibody (Ser255) IHC-plus; JUND; Activator protein 1; AP-1; JunD-FL isoform; Jun D proto-oncogene; Transcription factor jun-D; Human AP-1; JUND
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS with 0.09% (w/v) sodium azide
Purity/Purification
Immunoaffinity Purified
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Molecular Weight
35,174 Da
OMIM
165162
3D Structure
ModBase 3D Structure for P17535
Target Species
Human
Immunogen Description
KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S255 of human JUND.
Immunogen Type
Synthetic peptide
Immunogen
AP-1 / JUND antibody was raised against kLH conjugated synthetic peptide corresponding to amino acid residues surrounding S255 of human JUND.
Antigen Modification
Ser255
Applications Tested/Suitable for anti-AP-1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-AP-1 antibody
IHC-P (10 ug/ml), WB (1:1000)

Immunohistochemistry (IHC) of anti-AP-1 antibody

Anti-AP-1 / JUND antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-AP-1 Polyclonal Antibody – Cat# MBS248901

Western Blot (WB) of anti-AP-1 antibody

Western blot of anti-JUND Antibody (S255) in Jurkat cell line lysates (35 ug/lane). JUND (arrow) was detected using the purified Pab.
Rabbit Anti-AP-1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248901

Other Notes

Small volumes of anti-AP-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AP-1. It may not necessarily be applicable to this product.

NCBI GI #
102469037
NCBI GeneID
3727
NCBI Accession #
NP_005345.3
UniProt Primary Accession #
P17535
UniProt Secondary Accession #
Q53EK9
UniProt Related Accession #
P17535
GenBank Nucleotide #
NM_005354.5
NCBI Official Full Name
transcription factor jun-D isoform JunD-FL
NCBI Official Synonym Full Names
jun D proto-oncogene
NCBI Official Symbol
JUND
NCBI Official Synonym Symbols
AP-1
UniProt Protein Name
Transcription factor jun-D
UniProt Gene Name
JUND
UniProt Entry Name
JUND_HUMAN
NCBI Protein Information
transcription factor jun-D; JunD-FL isoform; activator protein 1

NCBI Summary for AP-1

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]
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UniProt Comments for AP-1

JunD: Transcription factor binding AP-1 sites. Binds DNA as a dimer. Interacts with MEN1; this interaction represses transcriptional activation. Belongs to the bZIP family. Jun subfamily.

Protein type: Transcription factor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: nucleoplasm; protein complex; chromatin; nucleus

Molecular Function: ligand-dependent nuclear receptor binding; protein binding; enzyme binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity

Biological Process: circadian rhythm; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; response to peptide hormone stimulus; positive regulation of osteoblast differentiation; response to light stimulus; response to mechanical stimulus; response to lipopolysaccharide; positive regulation of transcription from RNA polymerase II promoter; response to organic cyclic substance; osteoblast development; aging
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Research Articles on AP-1

1. Binding of specific AP-1 factors, we found JunD associated with the LILRB1 distal promoter.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AP-1 antibody

 Reference Product  PubMed Publications
 FOS antibody  >501 publications with AP-1 and FOS
 FOSB antibody  >170 publications with AP-1 and FOSB
 MEN1 antibody  >48 publications with AP-1 and MEN1
 FOSL2 antibody  >40 publications with AP-1 and FOSL2
 CDK4 antibody  >13 publications with AP-1 and CDK4
 MAPK8 antibody  >12 publications with AP-1 and MAPK8
 HBZ antibody  >11 publications with AP-1 and HBZ
 FOSL1 antibody  >6 publications with AP-1 and FOSL1
 EP300 antibody  >2 publications with AP-1 and EP300

Pathways associated with anti-AP-1 antibody

 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Hypertrophy Model Pathway antibodies  Hypertrophy Model Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Oncostatin M Signaling Pathway antibodies  Oncostatin M Signaling Pathway Diagram

Diseases associated with anti-AP-1 antibody

 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >49 publications with AP-1 and Cell Transformation, Neoplastic
 Necrosis Antibodies  >45 publications with AP-1 and Necrosis
 Inflammation Antibodies  >40 publications with AP-1 and Inflammation
 Liver Diseases Antibodies  >31 publications with AP-1 and Liver Diseases
 Disease Models, Animal Antibodies  >28 publications with AP-1 and Disease Models, Animal
 Fibrosis Antibodies  >25 publications with AP-1 and Fibrosis
 Cardiovascular Diseases Antibodies  >24 publications with AP-1 and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >23 publications with AP-1 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >19 publications with AP-1 and Kidney Diseases
 Hypertrophy Antibodies  >17 publications with AP-1 and Hypertrophy

Organs/Tissues associated with anti-AP-1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >119 publications with AP-1 and Blood
 Brain Antibodies  >105 publications with AP-1 and Brain
 Bone Antibodies  >68 publications with AP-1 and Bone
 Liver Antibodies  >57 publications with AP-1 and Liver
 Muscle Antibodies  >43 publications with AP-1 and Muscle
 Lung Antibodies  >38 publications with AP-1 and Lung
 Skin Antibodies  >37 publications with AP-1 and Skin
 Vascular Antibodies  >33 publications with AP-1 and Vascular
 Kidney Antibodies  >28 publications with AP-1 and Kidney
 Prostate Antibodies  >22 publications with AP-1 and Prostate
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