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C11orf2 / Fat-Free (VPS51) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS248914

MBS248914 is an antibody targeting VPS51. Also known as Rabbit Polyclonal to Human C11orf2 / Fat-Free. Reactive in Human. Host: Rabbit. More details

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Product Overview

Product Name
C11orf2 / Fat-Free (VPS51), Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human C11orf2 / Fat-Free
Product Gene Name
anti-VPS51 antibody
Product Synonym Gene Name
C11orf2
Product Synonym Names
Anti-C11orf2 / Fat-Free Antibody (C-Terminus) IHC-plus; ANG2; Another new gene 2 protein; C11orf3; FFR; Fat-free homolog; Protein fat-free homolog; ANG3; Human C11orf2; Fat-Free
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human C11orf2 / Fat-Free. At least two alternatively spliced isoforms are known to exist; this antibody will detect both isoforms.
Preparation and Storage
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
Molecular Weight
72,655 Da
OMIM
615738
3D Structure
ModBase 3D Structure for Q9UID3
Target Species
Human
Immunogen Description
An 18 amino acid peptide near the carboxy terminus of human Fat-free.
Immunogen Type
Synthetic peptide
Immunogen
C11orf2 / Fat-Free antibody was raised against an 18 amino acid peptide near the carboxy terminus of human Fat-free.
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-VPS51 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-VPS51 antibody
IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
Usage: Fat-free antibody can be used for detection of Fat-free by Western blot at 1-2 ug/mL.

Immunohistochemistry (IHC) of anti-VPS51 antibody

Anti-C11orf2 / Fat-Free antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-VPS51 Polyclonal Antibody – Cat# MBS248914

Western Blot (WB) of anti-VPS51 antibody

Western blot analysis of Fat Free in mouse brain tissue lysate with Fat Free antibody at 1 ug/ml.
Rabbit Anti-VPS51 Polyclonal Antibody, Western Blot (WB) – Cat# MBS248914

Other Notes

Small volumes of anti-VPS51 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VPS51. It may not necessarily be applicable to this product.

NCBI GI #
8393009
NCBI GeneID
738
NCBI Accession #
NP_037397.2
UniProt Primary Accession #
Q9UID3
UniProt Secondary Accession #
Q6PJV5; Q7L8A6; Q8WZ35; Q96DF4; Q96GR3
UniProt Related Accession #
Q9UID3
GenBank Nucleotide #
NM_013265.3
NCBI Official Full Name
vacuolar protein sorting-associated protein 51 homolog
NCBI Official Synonym Full Names
vacuolar protein sorting 51 homolog (S. cerevisiae)
NCBI Official Symbol
VPS51
NCBI Official Synonym Symbols
FFR; ANG2; ANG3; C11orf2; C11orf3
UniProt Protein Name
Vacuolar protein sorting-associated protein 51 homolog
UniProt Synonym Protein Names
Another new gene 2 protein; Protein fat-free homolog
Protein Family
Vacuolar protein sorting-associated protein
UniProt Gene Name
VPS51
UniProt Synonym Gene Names
ANG2; C11orf2; C11orf3; FFR
UniProt Entry Name
VPS51_HUMAN
NCBI Protein Information
vacuolar protein sorting-associated protein 51 homolog; protein fat-free homolog; another new gene 2 protein

NCBI Summary for VPS51

This gene encodes a member of the vacuolar protein sorting-associated protein 51 family. The encoded protein is a component of the Golgi-associated retrograde protein complex which acts as a tethering factor for carriers in retrograde transport from the early and late endosomes to the trans-Golgi network. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
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UniProt Comments for VPS51

FFR: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Belongs to the VPS51 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: Golgi apparatus; integral to membrane

Molecular Function: protein binding

Biological Process: protein transport; autophagy; lipid transport; retrograde transport, endosome to Golgi
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Research Articles on VPS51

1. A dityrosine motif of Ang2 interacts with a highly conserved groove in Syntaxin 6.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-VPS51 antibody

 Reference Product  PubMed Publications
 VPS53 antibody  >3 publications with VPS51 and VPS53

Organs/Tissues associated with anti-VPS51 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >2 publications with VPS51 and Vascular
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