ARHU Antibody – Rabbit Polyclonal

This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]

RHOU: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Belongs to the small GTPase superfamily. Rho family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, monomeric, Rho; G protein, monomeric; Motility/polarity/chemotaxis; G protein

Chromosomal Location of Human Ortholog: 1q42.11-q42.3

Cellular Component: Golgi membrane; cell projection; focal adhesion; plasma membrane; podosome; cytosol

Molecular Function: GTPase activity; protein binding; GTP binding; metal ion binding

Biological Process: regulation of cell shape; regulation of small GTPase mediated signal transduction; metabolic process; small GTPase mediated signal transduction; Rac protein signal transduction; cytoskeleton organization and biogenesis; actin cytoskeleton organization and biogenesis; G1/S transition of mitotic cell cycle