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GIPC1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS249164

MBS249164 is an antibody targeting GIPC1. Also known as Mouse Monoclonal [clone AT1G10] (IgG1,k) to Human GIPC1 / GIPC. Reactive in Human. Host: Mouse. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
GIPC1 / GIPC, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone AT1G10] (IgG1,k) to Human GIPC1 / GIPC
Product Gene Name
anti-GIPC1 antibody
Product Synonym Gene Name
GIPC
Product Synonym Names
Anti-GIPC1 / GIPC Antibody (clone AT1G10) IHC-plus; GIPC1; GIPC; GLUT1CBP; RGS19-interacting protein 1; RGS-GAIP-interacting protein; SEMCAP; SYNECTIIN; SYNECTIN; Tax interaction protein 2; RGS19IP1; TIP-2; C19orf3; Hs.6454; IIP-1; Nip; Human GIPC1; GIPC
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
AT1G10
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.4, 0.1% sodium azide
Purity/Purification
Protein G Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human SEMCAP / GIPC
Preparation and Storage
Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
Molecular Weight
26,072 Da
OMIM
605072
3D Structure
ModBase 3D Structure for O14908
Target Species
Human
Immunogen Description
Recombinant human GIPC2 (1-315aa) purified from E Coli.
Immunogen Type
Recombinant protein
Immunogen
GIPC1 / GIPC antibody was raised against recombinant human GIPC2 (1-315aa) purified from E Coli.
Applications Tested/Suitable for anti-GIPC1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-GIPC1 antibody
ELISA, IHC-P (10 ug/ml), WB (1:1000)

Immunohistochemistry (IHC) of anti-GIPC1 antibody

Anti-GIPC1 / GIPC antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Mouse Anti-GIPC1 Monoclonal Antibody – Cat# MBS249164

Western Blot (WB) of anti-GIPC1 antibody

Western Blot: The cell lysates (40 ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human GIPC antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. The cross-reacting of anti-human GIPC (AT1G10) were analyzed by using recombinant protein(20ng) of GIPC1 and GIPC2.
Mouse Anti-GIPC1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS249164

Other Notes

Small volumes of anti-GIPC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GIPC1. It may not necessarily be applicable to this product.

NCBI GI #
5031715
NCBI GeneID
10755
NCBI Accession #
NP_005707.1
UniProt Primary Accession #
O14908
UniProt Secondary Accession #
Q9BTC9; A8K4I3; A8MZG3
UniProt Related Accession #
O14908
GenBank Nucleotide #
NM_005716.3
NCBI Official Full Name
PDZ domain-containing protein GIPC1 isoform 1
NCBI Official Synonym Full Names
GIPC PDZ domain containing family, member 1
NCBI Official Symbol
GIPC1
NCBI Official Synonym Symbols
NIP; GIPC; IIP-1; TIP-2; SEMCAP; C19orf3; Hs.6454; GLUT1CBP; RGS19IP1; SYNECTIN; SYNECTIIN
UniProt Protein Name
PDZ domain-containing protein GIPC1
UniProt Synonym Protein Names
GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; RGS19-interacting protein 1; Synectin; Tax interaction protein 2; TIP-2
Protein Family
PDZ domain-containing protein
UniProt Gene Name
GIPC1
UniProt Synonym Gene Names
C19orf3; GIPC; RGS19IP1; TIP-2
UniProt Entry Name
GIPC1_HUMAN
NCBI Protein Information
PDZ domain-containing protein GIPC1; tax interaction protein 2; RGS19-interacting protein 1; RGS-GAIP-interacting protein; GLUT1 C-terminal binding protein; GAIP C-terminus-interacting protein; IGF-1 receptor interacting protein 1; regulator of G-protein signalling 19 interacting protein 1

NCBI Summary for GIPC1

GIPC1 is a scaffolding protein that regulates cell surface receptor expression and trafficking (Lee et al., 2008 [PubMed 18775991]).[supplied by OMIM, Apr 2009]

UniProt Comments for GIPC1

GIPC1: May be involved in G protein-linked signaling. Belongs to the GIPC family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; GAPs; GAPs, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: synaptic vesicle; membrane; endocytic vesicle; cytoplasmic membrane-bound vesicle; cytoplasm; dendritic spine; vesicle membrane; cell cortex; dendritic shaft; cytosol; brush border

Molecular Function: protein binding; protein homodimerization activity; myosin binding; actin binding; receptor binding; PDZ domain binding

Biological Process: positive regulation of cytokinesis; G-protein coupled receptor protein signaling pathway; synaptic transmission; glutamate secretion; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of protein stability; endothelial cell migration; regulation of synaptic plasticity; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; protein targeting
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Research Articles on GIPC1

1. GIPC binds LPA(1) and promotes its trafficking from APPL-containing signaling endosomes to EEA1 early endosomes and thus attenuates LPA-mediated Akt signaling from APPL endosomes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GIPC1 antibody

 Reference Product  PubMed Publications
 RGS19 antibody  >6 publications with GIPC1 and RGS19
 IGF1R antibody  >5 publications with GIPC1 and IGF1R
 MYO6 antibody  >5 publications with GIPC1 and MYO6
 NRP1 antibody  >4 publications with GIPC1 and NRP1
 NGF antibody  >2 publications with GIPC1 and NGF
 NTRK2 antibody  >2 publications with GIPC1 and NTRK2
 DRD2 antibody  >1 publications with GIPC1 and DRD2
 SLC2A1 antibody  >1 publications with GIPC1 and SLC2A1
 SDC4 antibody  >1 publications with GIPC1 and SDC4

Pathways associated with anti-GIPC1 antibody

 Products by Pathway  Pathway Diagram
 Neurotrophic Factor-mediated Trk Receptor Signaling Pathway antibodies  Neurotrophic Factor-mediated Trk Receptor Signaling Pathway Diagram
 Syndecan-4-mediated Signaling Events Pathway antibodies  Syndecan-4-mediated Signaling Events Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram

Diseases associated with anti-GIPC1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >14 publications with GIPC1 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >5 publications with GIPC1 and Ovarian Neoplasms
 Adenocarcinoma Antibodies  >4 publications with GIPC1 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >3 publications with GIPC1 and Cardiovascular Diseases
 Prostatic Neoplasms Antibodies  >2 publications with GIPC1 and Prostatic Neoplasms
 Heart Diseases Antibodies  >2 publications with GIPC1 and Heart Diseases
 Inflammation Antibodies  >1 publications with GIPC1 and Inflammation
 Kidney Diseases Antibodies  >1 publications with GIPC1 and Kidney Diseases
 Nervous System Diseases Antibodies  >1 publications with GIPC1 and Nervous System Diseases
 Insulin Resistance Antibodies  >1 publications with GIPC1 and Insulin Resistance

Organs/Tissues associated with anti-GIPC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >8 publications with GIPC1 and Lung
 Brain Antibodies  >8 publications with GIPC1 and Brain
 Vascular Antibodies  >6 publications with GIPC1 and Vascular
 Kidney Antibodies  >5 publications with GIPC1 and Kidney
 Heart Antibodies  >5 publications with GIPC1 and Heart
 Prostate Antibodies  >4 publications with GIPC1 and Prostate
 Muscle Antibodies  >3 publications with GIPC1 and Muscle
 Ovary Antibodies  >3 publications with GIPC1 and Ovary
 Intestine Antibodies  >2 publications with GIPC1 and Intestine
 Stomach Antibodies  >2 publications with GIPC1 and Stomach
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